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  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Columns 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Columns 3"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Columns 4"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Columns 5"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 3"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 4"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 5"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 6"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 7"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Grid 8"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 3"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 4"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 5"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 6"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 7"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table List 8"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table 3D effects 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table 3D effects 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table 3D effects 3"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Contemporary"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Elegant"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Professional"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Subtle 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Subtle 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Web 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Web 2"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Web 3"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Balloon Text"/>
  <w:LsdException Locked=3D"false" Priority=3D"39" Name=3D"Table Grid"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" UnhideWhenUsed=3D"tr=
ue"
   Name=3D"Table Theme"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" Name=3D"Placeholder =
Text"/>
  <w:LsdException Locked=3D"false" Priority=3D"1" QFormat=3D"true" Name=3D"=
No Spacing"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" SemiHidden=3D"true" Name=3D"Revision"/>
  <w:LsdException Locked=3D"false" Priority=3D"34" QFormat=3D"true"
   Name=3D"List Paragraph"/>
  <w:LsdException Locked=3D"false" Priority=3D"29" QFormat=3D"true" Name=3D=
"Quote"/>
  <w:LsdException Locked=3D"false" Priority=3D"30" QFormat=3D"true"
   Name=3D"Intense Quote"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"60" Name=3D"Light Shading Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"61" Name=3D"Light List Accen=
t 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"62" Name=3D"Light Grid Accen=
t 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"63" Name=3D"Medium Shading 1=
 Accent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"64" Name=3D"Medium Shading 2=
 Accent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"65" Name=3D"Medium List 1 Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"66" Name=3D"Medium List 2 Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"67" Name=3D"Medium Grid 1 Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"68" Name=3D"Medium Grid 2 Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"69" Name=3D"Medium Grid 3 Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"70" Name=3D"Dark List Accent=
 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"71" Name=3D"Colorful Shading=
 Accent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"72" Name=3D"Colorful List Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"73" Name=3D"Colorful Grid Ac=
cent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"19" QFormat=3D"true"
   Name=3D"Subtle Emphasis"/>
  <w:LsdException Locked=3D"false" Priority=3D"21" QFormat=3D"true"
   Name=3D"Intense Emphasis"/>
  <w:LsdException Locked=3D"false" Priority=3D"31" QFormat=3D"true"
   Name=3D"Subtle Reference"/>
  <w:LsdException Locked=3D"false" Priority=3D"32" QFormat=3D"true"
   Name=3D"Intense Reference"/>
  <w:LsdException Locked=3D"false" Priority=3D"33" QFormat=3D"true" Name=3D=
"Book Title"/>
  <w:LsdException Locked=3D"false" Priority=3D"37" SemiHidden=3D"true"
   UnhideWhenUsed=3D"true" Name=3D"Bibliography"/>
  <w:LsdException Locked=3D"false" Priority=3D"39" SemiHidden=3D"true"
   UnhideWhenUsed=3D"true" QFormat=3D"true" Name=3D"TOC Heading"/>
  <w:LsdException Locked=3D"false" Priority=3D"41" Name=3D"Plain Table 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"42" Name=3D"Plain Table 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"43" Name=3D"Plain Table 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"44" Name=3D"Plain Table 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"45" Name=3D"Plain Table 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"40" Name=3D"Grid Table Light=
"/>
  <w:LsdException Locked=3D"false" Priority=3D"46" Name=3D"Grid Table 1 Lig=
ht"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k"/>
  <w:LsdException Locked=3D"false" Priority=3D"51" Name=3D"Grid Table 6 Col=
orful"/>
  <w:LsdException Locked=3D"false" Priority=3D"52" Name=3D"Grid Table 7 Col=
orful"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"51"
   Name=3D"Grid Table 6 Colorful Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"52"
   Name=3D"Grid Table 7 Colorful Accent 1"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"51"
   Name=3D"Grid Table 6 Colorful Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"52"
   Name=3D"Grid Table 7 Colorful Accent 2"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"51"
   Name=3D"Grid Table 6 Colorful Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"52"
   Name=3D"Grid Table 7 Colorful Accent 3"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"51"
   Name=3D"Grid Table 6 Colorful Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"52"
   Name=3D"Grid Table 7 Colorful Accent 4"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"51"
   Name=3D"Grid Table 6 Colorful Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"52"
   Name=3D"Grid Table 7 Colorful Accent 5"/>
  <w:LsdException Locked=3D"false" Priority=3D"46"
   Name=3D"Grid Table 1 Light Accent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"47" Name=3D"Grid Table 2 Acc=
ent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"48" Name=3D"Grid Table 3 Acc=
ent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"49" Name=3D"Grid Table 4 Acc=
ent 6"/>
  <w:LsdException Locked=3D"false" Priority=3D"50" Name=3D"Grid Table 5 Dar=
k Accent 6"/>
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@list l7:level2
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	margin-left:36.0pt;
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	margin-left:72.0pt;
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	margin-left:90.0pt;
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@list l7:level7
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@list l7:level8
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	margin-left:144.0pt;
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@list l7:level9
	{mso-level-number-format:roman-lower;
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	margin-left:162.0pt;
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@list l8
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	margin-left:35.15pt;
	text-indent:-17.3pt;
	font-family:"Times New Roman",serif;}
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	{mso-level-number-format:bullet;
	mso-level-text:\F0D8;
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	{mso-level-number-format:bullet;
	mso-level-text:\F0A7;
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	text-indent:-18.0pt;
	font-family:Wingdings;}
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	{mso-level-number-format:bullet;
	mso-level-text:\F0B7;
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	margin-left:72.0pt;
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@list l8:level5
	{mso-level-number-format:bullet;
	mso-level-text:\F0A8;
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	font-family:Symbol;}
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	{mso-level-number-format:bullet;
	mso-level-text:\F0D8;
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	margin-left:108.0pt;
	text-indent:-18.0pt;
	font-family:Wingdings;}
@list l8:level7
	{mso-level-number-format:bullet;
	mso-level-text:\F0A7;
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@list l8:level8
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	{mso-level-number-format:bullet;
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@list l9
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	margin-left:5.65pt;
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	vertical-align:super;}
@list l9:level2
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	margin-left:36.0pt;
	text-indent:-18.0pt;}
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	margin-left:72.0pt;
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@list l9:level6
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	margin-left:72.0pt;
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@list l10:level6
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@list l13:level2
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@list l14
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</head>

<body lang=3DRU style=3D'tab-interval:35.4pt'>

<div class=3DWordSection1>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt;text-transform:uppercase'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.0001=
pt;
text-align:center'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;text-transform:uppercase'>ІНСТРУКЦІЯ<o:p=
></o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.0001=
pt;
text-align:center'><b style=3D'mso-bidi-font-weight:normal'><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>для медичного застосування лікарського =
засобу<o:p></o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.0001=
pt;
text-align:center'><b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У=
ЛЬТОМІРІС<o:p></o:p></span></b></p>

<p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.0001=
pt;
text-align:center'><b><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(=
ULTOMIRIS)<o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Склад:<span style=3D'mso-bidi-font-style:italic'><o:p></o:p></span>=
</span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>діюча речовина: равулізумаб (=
ravulizumab);<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 мл стерильного концентрату =
для
розчину для інфузій містить 100 мг равулізумабу;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 флакон зі стерильним концен=
тратом для
розчину для інфузій по 3&nbsp;мл містить 300&nbsp;мг равулізумабу
(100&nbsp;мг/мл);<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 флакон зі стерильним концен=
тратом
для розчину для інфузій по 11&nbsp;мл містить 1100&nbsp;мг равулізумабу
(100&nbsp;мг/мл);<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>після розведення кінцева конц=
ентрація
розчину для інфузій становить 50&nbsp;мг/мл;<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>допоміжні речовини: натрію фо=
сфат
одноосновний моногідрат, натрію фосфат двоосновний гептагідрат, </span><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>L<=
/span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-аргінін, сахароза, полісорба=
т 80, вода
для ін’єкцій.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Лікарська форма. </span></b><span lang=3DUK style=3D'mso-bidi-font-=
size:
12.0pt'>Концентрат для розчину для інфузій.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Основні фізико-хімічні власти=
вості: напівпрозорий
розчин від безбарвного до жовтуватого кольору, практично вільний від часток=
.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Фармакотерапевтична група. </span></b><span lang=3DUK style=3D'mso-=
bidi-font-size:
12.0pt'>Імуносупресанти. Інгібітори комплементу. Равулізумаб. Код&nbsp;АТХ =
L04A
J02.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk171421678"><b style=3D'mso-bidi-font-weight:normal'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>Фармакологічні властивості<span style=3D'mso-bidi-font-weight:bold;
mso-bidi-font-style:italic'><o:p></o:p></span></span></i></b></a></p>

<span style=3D'mso-bookmark:_Hlk171421678'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Фармакодинаміка<o:p></o:p></s=
pan></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Механізм дії <o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб є моноклональним
антитілом IgG<sub>2/4K</sub>, яке специфічно зв’язується з білком С5
комплементу, пригнічуючи в такий спосіб його розщеплення до С5а (прозапальн=
ий
анафілатоксин) та С5b (субодиниця, яка ініціює мембраноатакувальний комплекс
[MAК або C5b-9]) і запобігаючи утворенню С5b-9. Равулізумаб зберігає актива=
цію
ранніх компонентів комплементу, які необхідні для опсонізації мікроорганізм=
ів і
кліренсу імунних комплексів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Фармакодинамічні ефекти<o:p><=
/o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Як у дорослих пацієнтів і пац=
ієнтів
дитячого віку з пароксизмальною нічною гемоглобінурією (ПНГ), які раніше не
отримували лікування інгібіторами комплементу, так і в тих, хто отримував
екулізумаб у клінічних дослідженнях 3 фази, спостерігалося негайне, повне та
стійке інгібування вільного С5 у сироватці (концентрація &lt; 0,5&nbsp;мкг/=
мл)
до кінця першого інфузійного введення равулізумабу, що зберігалося впродовж
усього 26-тижневого періоду лікування у всіх пацієнтів. Негайне і повне
інгібування вільного С5 у сироватці крові також спостерігалося в дорослих
пацієнтів і пацієнтів дитячого віку з атиповим гемолітико-уремічним синдром=
ом (аГУС),
у дорослих пацієнтів з генералізованою міастенією гравіс (гМГ) і дорослих
пацієнтів з оптиконевромієлітом з розладом спектру (ОНМРС) до кінця першого
інфузійного введення і протягом усього періоду первинного лікування.<o:p></=
o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Спостерігалася залежність сту=
пеня та
тривалості фармакодинамічної відповіді в пацієнтів з ПНГ, аГУС, гМГ і ОНМРС=
 від
експозиції равулізумабу. Рівні вільного С5 &lt; 0,5&nbsp;мкг/мл корелювали з
максимальним контролем внутрішньосудинного гемолізу та повним інгібуванням
термінальних компонентів комплементу. При гМГ активація термінальних
компонентів комплементу призводить до відкладення МАК у нервово-м’язовому
з’єднанні та до порушення нервово-м’язової передачі. При ОНМРС активація
термінальних компонентів комплементу призводить до утворення МАК і
С5а-залежного запалення, некрозу астроцитів і пошкодження навколишніх гліал=
ьних
клітин і нейронів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клінічна ефективність та безп=
ека<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk174465963"><i><span lang=3DUK style=3D'mso-bidi-font-size:12.0p=
t'>Пароксизмальна
нічна гемоглобінурія </span></i></a><i><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
12.0pt'>(ПНГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Безпеку та ефективність засто=
сування равулізумабу
дорослим пацієнтам з ПНГ оцінювали у двох відкритих рандомізованих
контрольованих дослідженнях 3 фази з активним контролем:<o:p></o:p></span><=
/p>

<p class=3DMsoListParagraphCxSpFirst style=3D'margin-top:0cm;margin-right:0=
cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l25 level1 lfo23'><![if !s=
upportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>дослідження
за участю дорослих пацієнтів із ПНГ, які раніше не отримували лікування
інгібіторами комплементу;<o:p></o:p></span></p>

<p class=3DMsoListParagraphCxSpLast style=3D'margin-top:0cm;margin-right:0c=
m;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l25 level1 lfo23'><![if !s=
upportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>дослідження
за участю дорослих пацієнтів із ПНГ, які перебували у клінічно стабільному
стані після лікування екулізумабом протягом щонайменше 6 попередніх місяців=
.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб застосовували від=
повідно
до рекомендацій щодо дозування, викладених у розділі&nbsp; «Спосіб застосув=
ання
та дози» (4 інфузійних введення равулізумабу протягом 26&nbsp;тижнів), тоді=
 як
екулізумаб вводили згідно зі схваленим режимом дозування: 600&nbsp;мг лікар=
ського
засобу щотижня протягом перших 4 тижнів і 900&nbsp;мг кожні 2 тижні (15
інфузійних введень протягом 26 тижнів).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти були вакциновані про=
ти
менінгококової інфекції перед лікуванням равулізумабом або екулізумабом чи =
на
момент початку такого лікування або отримували профілактичне лікування
відповідними антибіотиками протягом 2 тижнів після вакцинації.<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Значущих відмінностей у демог=
рафічних
або вихідних характеристиках між групами лікування равулізумабом або екуліз=
умабом
не відмічено в жодному з досліджень 3 фази. Анамнез трансфузій за попередні=
 12
місяців був схожим у групах лікування равулізумабом та екулізумабом у кожно=
му з
досліджень 3 фази.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p><span style=3D'text-decoration:none'>&nbsp;</span></o:p></span>=
</u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Дослідження </span></u><u><span lang=3DUK style=3D'mso-bidi-font-siz=
e:12.0pt'>за
участю дорослих пацієнтів з ПНГ, які раніше не отримували лікування
інгібіторами комплементу (дослідження ALXN1210-PNH-301)<o:p></o:p></span></=
u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю пацієнт=
ів, які
раніше не отримували лікування інгібіторами комплементу, було 26-тижневим
багатоцентровим, відкритим, рандомізованим, активно контрольованим дослідже=
нням
3 фази за участю 246 пацієнтів, які до включення в дослідження не отримували
лікування інгібіторами комплементу, з подальшим довготривалим додатковим
періодом, протягом якого всі пацієнти отримували равулізумаб. У пацієнтів, =
які
відповідали критеріям включення в це дослідження, повинна була бути
продемонстрована висока активність захворювання, що визначається як активні=
сть лактатдегідрогенази
(ЛДГ) &#8805;&nbsp;1,5 &times; верхня межа норми (ВМН) при скринінгу, а так=
ож
наявність 1 або більше з таких ознак чи симптомів, пов’язаних із ПНГ, протя=
гом
3 місяців скринінгу: втомлюваність, гемоглобінурія, біль у животі, задишка,
анемія (гемоглобін &lt;&nbsp;10&nbsp;г/дл), наявність в анамнезі серйозних
небажаних явищ з боку судин (включно з тромбозом), дисфагія чи еректильна
дисфункція – або переливання еритроцитарної маси в анамнезі у зв’язку з ПНГ=
.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Понад 80&nbsp;% пацієнтів в о=
бох
групах лікування перенесли гемотрансфузію протягом 12 місяців до включення в
дослідження. У більшої частини пацієнтів досліджуваної популяції, які раніш=
е не
отримували інгібітори комплементу, був виражений гемоліз на вихідному рівні=
; у
86,2&nbsp;% включених у дослідження пацієнтів була підвищена активність ЛДГ
&#8805; 3 &times; ВМН, яка є прямим показником внутрішньосудинного гемолізу=
 при
ПНГ.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 1 представлено вихі=
дні
характеристики включених у дослідження пацієнтів із ПНГ, які раніше не
отримували лікування інгібіторами комплементу, при цьому явні клінічно знач=
ущі
відмінності між групами лікування були відсутні.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 1</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідні характеристики включе=
них у
дослідження пацієнтів, які раніше не отримували інгібітори комплементу<o:p>=
</o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D604
 style=3D'width:453.35pt;border-collapse:collapse;border:none;mso-border-al=
t:
 solid windowtext .25pt;mso-table-overlap:never;mso-padding-alt:0cm .5pt 0c=
m .5pt;
 mso-border-insideh:.25pt solid windowtext;mso-border-insidev:.25pt solid w=
indowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:27.2pt'>
  <td width=3D221 style=3D'width:166.1pt;border:solid windowtext 1.0pt;mso-=
border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:27.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Параметр<b><o:p></o:p></b><=
/span></p>
  </td>
  <td width=3D84 style=3D'width:63.1pt;border:solid windowtext 1.0pt;border=
-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:27.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Статис-тичні дані<b><o:p></=
o:p></b></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  27.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;125)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  27.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ек=
улізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;121)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.9pt'>
  <td width=3D221 rowspan=3D3 valign=3Dtop style=3D'width:166.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік (років) на момент встан=
овлення
  діагнозу ПНГ<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>37=
,9
  (14,90)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>39=
,6
  (16,65)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.9pt'>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
,0<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>36=
,5<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:39.0pt'>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:39.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мін., макс.<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:39.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
,81<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:39.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>13=
,82<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.9pt'>
  <td width=3D221 rowspan=3D3 valign=3Dtop style=3D'width:166.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік (років) на момент викон=
ання
  першої інфузії в дослідженні<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>44=
,8
  (15,16)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>46=
,2
  (16,24)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.6pt'>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>43=
,0<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:11.6pt'>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мін., макс.<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18=
,83<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18=
,86<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.6pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Стать (n, %)<o:p></o:p></sp=
an></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Чоловіча<o:p></o:p></span><=
/p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>65=
 (52,0)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>69=
 (57,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:11.6pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Жіноча<o:p></o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60=
 (48,0)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>52=
 (43,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:11.6pt'>
  <td width=3D221 rowspan=3D2 valign=3Dtop style=3D'width:166.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ до лікування=
<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>16=
33,5
  (778,75)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
78,3
  (727,06)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:11.6pt'>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.6pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
13,5<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
45,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:35.05pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:35.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, які пе=
ренесли
  переливання еритроцитарної маси протягом 12 місяців до введення першої до=
зи<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:35.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:35.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
3 (82,4)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:35.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
0 (82,6)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:11.9pt'>
  <td width=3D221 rowspan=3D3 valign=3Dtop style=3D'width:166.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 1.0cm 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість одиниць еритроцит=
арної
  маси, перелитої протягом 12 місяців до введення першої дози<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Усього<o:p></o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>92=
5<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>86=
1<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:11.9pt'>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9,=
0 (7,74)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8,=
6 (7,90)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:11.9pt'>
  <td width=3D84 style=3D'width:63.1pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6,=
0<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6,=
0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:11.9pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальний розмір клону ПНГ в
  еритроцитах<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>33=
,6<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
,2<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:11.9pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальний розмір клону ПНГ в
  гранулоцитах<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dbottom style=3D'width:63.1pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>93=
,8<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>92=
,4<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:22.7pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти з будь-якими прояв=
ами ПНГ<sup>а</sup>
  до отримання інформованої згоди<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
1 (96,8)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
0 (99,2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анемія<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
3 (82,4)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
5 (86,8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гематурія чи гемоглобінурія=
<o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>81=
 (64,8)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>75=
 (62,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:20;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Апластична анемія<o:p></o:p=
></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dbottom style=3D'width:112.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>41=
 (32,8)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dbottom style=3D'width:111.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>38=
 (31,4)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:21;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ниркова недостатність<o:p><=
/o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19=
 (15,2)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
 (9,1)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:22;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мієлодиспластичний синдром<=
o:p></o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7 =
(5,6)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6 =
(5,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:23;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ускладнення вагітності<o:p>=
</o:p></span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3 =
(2,4)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4 =
(3,3)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:24;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D221 valign=3Dtop style=3D'width:166.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 13.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інше<sup>б</sup><o:p></o:p>=
</span></p>
  </td>
  <td width=3D84 valign=3Dtop style=3D'width:63.1pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D150 valign=3Dtop style=3D'width:112.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>27=
 (21,6)<o:p></o:p></span></p>
  </td>
  <td width=3D149 valign=3Dtop style=3D'width:111.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>13=
 (10,7)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167164483"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>а</span></sup></a><span
style=3D'mso-bookmark:_Ref167164483'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> На підставі історії хвороби.</span></span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167164489"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>б</span></sup></a><span
style=3D'mso-bookmark:_Ref167164489'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>&nbsp;«Інше» відповідно до вказівки в індивідуальній реєстраційній
картці включало тромбоцитопенію, хронічну хворобу нирок і панцитопенію, а т=
акож
низку інших захворювань.</span></span><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Співпервинними кінцевими точк=
ами були
можливість уникнути переливань крові та гемоліз, який безпосередньо оцінюва=
ли
за нормалізацією активності ЛДГ (активність
ЛДГ&nbsp;&#8804;&nbsp;1&nbsp;&times;&nbsp;ВМН; ВМН для ЛДГ становить
246&nbsp;Од/л). Ключовими вторинними кінцевими точками були відсоткова змін=
а активності
ЛДГ від вихідного значення, зміна якості життя (опитувальник FACIT-Fatigue),
частка пацієнтів із проривним гемолізом і частка пацієнтів зі стабілізованим
рівнем гемоглобіну.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб не поступався еку=
лізумабу
за обома первинними кінцевими точками&nbsp;—&nbsp;можливістю уникнути
переливання еритроцитарної маси згідно з рекомендаціями, передбаченими
протоколом, і нормалізацією активності ЛДГ з 29 по 183 день, а також за всі=
ма 4
ключовими вторинними кінцевими точками (рисунок 1).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DEN-US style=3D'mso-ansi-language:EN-US;mso-fareast-language:EN-US;
mso-bidi-language:AR-SA;layout-grid-mode:both;mso-no-proof:yes'><v:shapetype
 id=3D"_x0000_t75" coordsize=3D"21600,21600" o:spt=3D"75" o:preferrelative=
=3D"t"
 path=3D"m@4@5l@4@11@9@11@9@5xe" filled=3D"f" stroked=3D"f">
 <v:stroke joinstyle=3D"miter"/>
 <v:formulas>
  <v:f eqn=3D"if lineDrawn pixelLineWidth 0"/>
  <v:f eqn=3D"sum @0 1 0"/>
  <v:f eqn=3D"sum 0 0 @1"/>
  <v:f eqn=3D"prod @2 1 2"/>
  <v:f eqn=3D"prod @3 21600 pixelWidth"/>
  <v:f eqn=3D"prod @3 21600 pixelHeight"/>
  <v:f eqn=3D"sum @0 0 1"/>
  <v:f eqn=3D"prod @6 1 2"/>
  <v:f eqn=3D"prod @7 21600 pixelWidth"/>
  <v:f eqn=3D"sum @8 21600 0"/>
  <v:f eqn=3D"prod @7 21600 pixelHeight"/>
  <v:f eqn=3D"sum @10 21600 0"/>
 </v:formulas>
 <v:path o:extrusionok=3D"f" gradientshapeok=3D"t" o:connecttype=3D"rect"/>
 <o:lock v:ext=3D"edit" aspectratio=3D"t"/>
</v:shapetype><v:shape id=3D"Picture_x0020_1" o:spid=3D"_x0000_i1025" type=
=3D"#_x0000_t75"
 alt=3D"A graph with numbers and a line&#10;&#10;AI-generated content may b=
e incorrect."
 style=3D'width:477.75pt;height:180pt;visibility:visible'>
 <v:imagedata src=3D"UA212780101_35E4.files/image001.jpg" o:title=3D"A grap=
h with numbers and a line&#10;&#10;AI-generated content may be incorrect"/>
</v:shape></span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-=
no-proof:
yes'><span style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'><o:p></o:p></sp=
an></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ЛДГ — лактатдегідрогеназа, ДІ=
 —
довірчий інтервал, FACIT — опитувальник функціональної оцінки терапії
хронічного захворювання.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Примітка. Чорний трикутник вк=
азує на
межі не меншої ефективності, сірі точки вказують на точкові оцінки.<o:p></o=
:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Рис. 1. Аналіз спів</span><span lang=3DUK style=3D'mso-bidi-font-siz=
e:12.0pt'>первинних
та вторинних кінцевих точок — повна вибірка для аналізу (дослідження за уча=
стю
пацієнтів, які ніколи раніше не отримували лікування інгібіторами комплемен=
ту)</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У заключний аналіз ефективнос=
ті
дослідження були включені дані усіх пацієнтів, які коли-небудь отримували
лікування равулізумабом (n =3D 244), а медіанна тривалість лікування станов=
ила
1423 дні. Заключний аналіз підтвердив, що відповіді на лікування равулізума=
бом,
які спостерігалися під час періоду первинної оцінки, зберігалися протягом
усього дослідження.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю дорослих
пацієнтів із ПНГ, які раніше отримували лікування екулізумабом (дослідження
ALXN1210-PNH-302)<o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Дослідження </span><span lang=3DUK style=3D'mso-bidi-font-size:12.0p=
t'>за
участю пацієнтів, які раніше отримували лікування екулізумабом, було
26-тижневим багатоцентровим, відкритим, рандомізованим, активно контрольова=
ним
дослідженням 3 фази за участю 195 пацієнтів із ПНГ у клінічно стабільному с=
тані
(ЛДГ &#8804; 1,5&nbsp;&times;&nbsp;ВМН) після лікування екулізумабом упродо=
вж
щонайменше останніх 6 місяців, після чого розпочався довготривалий додатков=
ий
період, під час якого всі пацієнти отримували равулізумаб.<o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анамнез ПНГ був схожим у груп=
ах
лікування равулізумабом та екулізумабом. Анамнез трансфузій за попередні 12
місяців був схожим у групах лікування равулізумабом та екулізумабом; понад
87&nbsp;% пацієнтів в обох групах не отримували переливання крові впродовж =
12
місяців до включення в дослідження. Середній загальний розмір клону ПНГ в
еритроцитах становив 60,05&nbsp;%, середній загальний розмір клону ПНГ у
гранулоцитах становив 83,30&nbsp;%, а середній загальний розмір клону ПНГ у
моноцитах становив 85,86&nbsp;%.</span><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'><o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 2 представлено вихі=
дні
характеристики включених у дослідження пацієнтів із ПНГ, які брали участь у
дослідженні з екулізумабом, при цьому явні клінічно значущі відмінності між
групами лікування були відсутні.<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 2<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідні характеристики включе=
них у
дослідження пацієнтів, які раніше отримували лікування екулізумабом<o:p></o=
:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'border-collapse:collapse;border:none;mso-border-alt:solid windowt=
ext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:26.95pt'>
  <td width=3D276 style=3D'width:207.1pt;border:solid windowtext 1.0pt;mso-=
border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметр<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:solid windowtext 1.0pt;border=
-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D118 valign=3Dtop style=3D'width:88.55pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;97)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D119 valign=3Dtop style=3D'width:89.05pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ек=
улізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;98)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:48.1pt'>
  <td width=3D276 rowspan=3D3 valign=3Dtop style=3D'width:207.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 1.4pt 0cm 5.65pt;
  height:48.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік (років) на момент встан=
овлення
  діагнозу ПНГ<o:p></o:p></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:48.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:48.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
,1
  (14,41)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:48.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>36=
,8
  (14,14)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:12.2pt'>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>32=
,0<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>35=
,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:12.2pt'>
  <td width=3D90 style=3D'width:67.7pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мін., макс.<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6,=
73<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
,74<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:12.2pt'>
  <td width=3D276 rowspan=3D3 valign=3Dtop style=3D'width:207.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік (років) на момент викон=
ання
  першої інфузії в дослідженні<o:p></o:p></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>46=
,6
  (14,41)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>48=
,8
  (13,97)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:12.2pt'>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
,0<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>49=
,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:12.2pt'>
  <td width=3D90 style=3D'width:67.7pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мін., макс.<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18=
,79<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>23=
,77<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:12.2pt'>
  <td width=3D276 valign=3Dtop style=3D'width:207.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Стать (n, %)<o:p></o:p></sp=
an></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Чоловіча<o:p></o:p></span><=
/p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>50=
 (51,5)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>48=
 (49,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:12.2pt'>
  <td width=3D276 valign=3Dtop style=3D'width:207.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Жіноча<o:p></o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>47=
 (48,5)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>50=
 (51,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:12.2pt'>
  <td width=3D276 rowspan=3D2 valign=3Dtop style=3D'width:207.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ до лікування=
<o:p></o:p></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>22=
8,0
  (48,71)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>23=
5,2
  (49,71)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:12.2pt'>
  <td width=3D90 style=3D'width:67.7pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:12.2pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>22=
4,0<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>23=
4,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:22.7pt'>
  <td width=3D276 valign=3Dtop style=3D'width:207.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 1.4pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, які пе=
ренесли
  переливання еритроцитарної маси / цільної крові протягом 12 місяців до
  введення першої дози<o:p></o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 1.4pt =
0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D118 valign=3Dtop style=3D'width:88.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>13=
 (13,4)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dtop style=3D'width:89.05pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
 (12,2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:11.9pt'>
  <td width=3D276 rowspan=3D3 valign=3Dtop style=3D'width:207.1pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 11.35pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість одиниць еритроцит=
арної
  маси / цільної крові, перелитої протягом 12&nbsp;місяців до введення перш=
ої
  дози <o:p></o:p></span></p>
  </td>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Усього<o:p></o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
3<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>50=
<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:11.9pt'>
  <td width=3D90 style=3D'width:67.7pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7,=
9 (8,78)<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4,=
2 (3,83)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:11.9pt'>
  <td width=3D90 style=3D'width:67.7pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D118 style=3D'width:88.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4,=
0<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.05pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2,=
5<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:22.7pt'>
  <td width=3D276 valign=3Dtop style=3D'width:207.1pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 1.4pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти з будь-якими прояв=
ами ПНГ<sup>а</sup>
  до отримання інформованої згоди<o:p></o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
1.4pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D118 valign=3Dtop style=3D'width:88.55pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>90=
 (92,8)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dtop style=3D'width:89.05pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>96=
 (98,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анемія<o:p></o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>64=
 (66,0)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>67=
 (68,4)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гематурія чи гемоглобінурія=
<o:p></o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>47=
 (48,5)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>48=
 (49,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Апластична анемія<o:p></o:p=
></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
 (35,1)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>39=
 (39,8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ниркова недостатність<o:p><=
/o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
 (11,3)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7 =
(7,1)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:20;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мієлодиспластичний синдром<=
o:p></o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3 =
(3,1)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6 =
(6,1)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:21;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ускладнення вагітності<o:p>=
</o:p></span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4 =
(4,1)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9 =
(9,2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:22;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D276 valign=3Dbottom style=3D'width:207.1pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm 13.05pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інше<sup>б</sup><o:p></o:p>=
</span></p>
  </td>
  <td width=3D90 valign=3Dtop style=3D'width:67.7pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D118 valign=3Dbottom style=3D'width:88.55pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
 (14,4)<o:p></o:p></span></p>
  </td>
  <td width=3D119 valign=3Dbottom style=3D'width:89.05pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
 (14,3)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167167357"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>а</span></sup></a><span
style=3D'mso-bookmark:_Ref167167357'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> На підставі історії хвороби.</span></span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167167367"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>б</span></sup></a><span
style=3D'mso-bookmark:_Ref167167367'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> «Інше» включає нейтропенію, порушення функції нирок і тромбоцитопе=
нію,
а також низку інших захворювань</span></span><span lang=3DUK style=3D'mso-b=
idi-font-size:
12.0pt'>.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Первинною кінцевою точкою був
гемоліз, оцінений за відсотковою зміною активності ЛДГ від вихідного значен=
ня.
Вторинна кінцева точка включала частку пацієнтів із проривним гемолізом, як=
ість
життя (FACIT-Fatigue), можливість уникнути переливання крові та частку
пацієнтів зі стабілізованим рівнем гемоглобіну.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб не поступався еку=
лізумабу
за первинною кінцевою точкою — відсотковою зміною активності ЛДГ від вихідн=
ого
значення до 183-го дня, а також за всіма 4 ключовими вторинними кінцевими
точками (рисунок 2).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p>&nbsp;</o:p><=
/span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US;mso=
-fareast-language:
EN-US;mso-bidi-language:AR-SA;layout-grid-mode:both;mso-no-proof:yes'><v:sh=
ape
 id=3D"Picture_x0020_4" o:spid=3D"_x0000_i1026" type=3D"#_x0000_t75" alt=3D=
"A graph with lines and numbers&#10;&#10;AI-generated content may be incorr=
ect."
 style=3D'width:482.25pt;height:192.75pt;visibility:visible'>
 <v:imagedata src=3D"UA212780101_35E4.files/image002.jpg" o:title=3D"A grap=
h with lines and numbers&#10;&#10;AI-generated content may be incorrect"/>
</v:shape></span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-no-=
proof:
yes'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-no-proof:yes'><span
style=3D'mso-spacerun:yes'> </span></span><span lang=3DEN-US style=3D'mso-b=
idi-font-size:
12.0pt;mso-ansi-language:EN-US'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ЛДГ — лактатдегідрогеназа, ДІ=
 —
довірчий інтервал.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Примітка. Чорний трикутник вк=
азує на
межі не меншої ефективності, сірі точки вказують на точкові оцінки.<o:p></o=
:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рис. 2. Аналіз первинних та в=
торинних
кінцевих точок — повна вибірка для аналізу (дослідження за участю пацієнтів,
які раніше отримували лікування екулізумабом)<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Заключний аналіз ефективності=
 включав
дані усіх пацієнтів, які коли-небудь отримували лікування равулізумабом (n =
=3D 192),
а середня тривалість лікування становила 968 днів. Заключний аналіз підтвер=
див,
що відповіді на лікування равулізумабом, які спостерігалися під час періоду
первинної оцінки, зберігалися протягом усього дослідження.<o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Атиповий гемолітико-уремічний=
 синдром
(аГУС) <o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю дорослих
пацієнтів з аГУС (дослідження ALXN1210-aHUS-311)<o:p></o:p></span></u></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю дорослих
пацієнтів було багатоцентровим дослідженням 3 фази, яке проводили в одній г=
рупі
за участю пацієнтів з підтвердженим аГУС, які до включення в дослідження не
отримували лікування інгібіторами комплементу і у яких була підтверджена
тромботична мікроангіопатія (ТМА). Дослідження складалося з 26-тижневого
періоду первинної оцінки, після чого пацієнтів могли включати в додатковий
період тривалістю до 4,5 року.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загалом у дослідження було вк=
лючено
58 пацієнтів із підтвердженим аГУС. Критерії участі в дослідженні виключали
пацієнтів із ТМА через дефіцит ферменту ADAMTS13, гемолітико-уремічним синд=
ромом,
пов’язаним із токсином Шига <i>Escherichia coli</i> (STEC-ГУС), та генетичн=
им
дефектом метаболізму кобаламіну С. Двоє пацієнтів були виключені з повної
вибірки для аналізу через підтверджений діагноз STEC-ГУС. У 93&nbsp;% паціє=
нтів
початково були позаниркові ознаки (з боку серцево-судинної системи, дихальн=
ої
системи, центральної нервової системи, шлунково-кишкового тракту, шкіри,
скелетних м’язів) або симптоми аГУС.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 3 представлено демо=
графічні
та вихідні характеристики 56 дорослих пацієнтів, включених у дослідження
ALXN1210-aHUS-311, які склали повну вибірку для аналізу.</span><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p></o:p></span>=
</p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p>&nbsp;</o:p><=
/span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 3 <span
style=3D'mso-tab-count:1'>     </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідні характеристики включе=
них у
дослідження дорослих пацієнтів<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:453.8pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:26.95pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметр<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D124 valign=3Dtop style=3D'width:93.1pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D217 valign=3Dtop style=3D'width:162.7pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;56)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:22.7pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік на момент першого інфуз=
ійного
  введення (років)<o:p></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
н.,
  макс.<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>42=
,2
  (14,98)<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19=
,5, 76,6<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:5.65pt'>
  <td width=3D264 valign=3Dbottom style=3D'width:198.0pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:5.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Стать<o:p></o:p></span></p>
  </td>
  <td width=3D124 rowspan=3D2 valign=3Dbottom style=3D'width:93.1pt;border-=
top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:5.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D217 rowspan=3D2 valign=3Dbottom style=3D'width:162.7pt;border=
-top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:5.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19=
 (33,9)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:8.75pt'>
  <td width=3D264 valign=3Dbottom style=3D'width:198.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 10.2pt;height:8.75pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Чоловіча<o:p></o:p></span><=
/p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:14.15pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Раса<o:p></o:p></span></p>
  </td>
  <td width=3D124 rowspan=3D2 valign=3Dtop style=3D'width:93.1pt;border-top=
:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D217 rowspan=3D2 style=3D'width:162.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
 (26,8)<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>29=
 (51,8)<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
 (21,4)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:36.85pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 10.2pt;height:36.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Монголоїдна<o:p></o:p></spa=
n></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Європеоїдна<o:p></o:p></spa=
n></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Невідомо/інша<o:p></o:p></s=
pan></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:11.35pt'>
  <td width=3D264 valign=3Dbottom style=3D'width:198.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Трансплантація в анамнезі<o=
:p></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(14,3)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:21.85pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:21.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тромбоцити (10<sup>9</sup>/=
л)<o:p></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:21.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n<=
o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:21.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>95=
,25 (18</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 473)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:23.5pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:23.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гемоглобін (г/л)<o:p></o:p>=
</span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n<=
o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>85=
,00
  (60,5</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ans=
i-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 140)<=
o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:23.5pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:23.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ (Од/л) у сир=
оватці<o:p></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n<=
o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>50=
8,00
  (229,5</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>; </span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3249)=
<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:23.5pt'>
  <td width=3D264 valign=3Dtop style=3D'width:198.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:23.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ (мл/хв/1,73&nbsp;м<sup=
>2</sup>)<o:p></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>55=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
,00 (4</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 80)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:12.0pt'>
  <td width=3D264 valign=3Dbottom style=3D'width:198.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:12.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти на діалізі<o:p></o=
:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:12.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>N =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:12.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>29=
 <b>(</b>51,8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D264 valign=3Dbottom style=3D'width:198.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтки після пологів<o:p=
></o:p></span></p>
  </td>
  <td width=3D124 valign=3Dbottom style=3D'width:93.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>N =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D217 valign=3Dbottom style=3D'width:162.7pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(14,3)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ — розрахункова швидкість
клубочкової фільтрації, ЛДГ&nbsp;—&nbsp;лактатдегідрогеназа, макс.</span><s=
pan
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>— максимальне значення, мін. —
мінімальне значення.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Примітка. Відсоткове співвідн=
ошення
засноване на загальній кількості пацієнтів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Первинною кінцевою точкою бул=
а повна
відповідь ТМА протягом 26-тижневого періоду первинної оцінки, про що свідчи=
ли
нормалізація гематологічних показників (кількість тромбоцитів &#8805;
150&nbsp;&times;&nbsp;10<sup>9</sup>/л та активність ЛДГ &#8804; 246&nbsp;О=
д/л)
і поліпшення рівня креатиніну в сироватці крові на &#8805; 25&nbsp;% від
вихідного значення. Пацієнти повинні були відповідати всім критеріям повної
відповіді ТМА під час двох окремих оцінювань, проведених з інтервалом
щонайменше 4 тижні (28 днів), та під час будь-яких проміжних вимірювань.<o:=
p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА спостеріг=
алася у
30 з 56 пацієнтів (53,6 %) у ході 26-тижневого періоду первинної оцінки, як
показано в таблиці 4.</span><span style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
RU'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p>&nbsp;</o:p><=
/span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 4 <span style=3D'mso-tab-count:1'>  =
   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА та аналіз
компонентів повної відповіді ТМА за 26-тижневий період первинної оцінки
(дослідження ALXN1210-aHUS-311)<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:453.85pt;border-collapse:collapse;border:none;mso-border-to=
p-alt:
 .5pt;mso-border-left-alt:.25pt;mso-border-bottom-alt:.25pt;mso-border-righ=
t-alt:
 .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;mso-table-=
overlap:
 never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid win=
dowtext;
 mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:12.5pt'>
  <td width=3D216 rowspan=3D2 valign=3Dtop style=3D'width:162.0pt;border:so=
lid windowtext 1.0pt;
  mso-border-top-alt:.5pt;mso-border-left-alt:.25pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D100 rowspan=3D2 valign=3Dtop style=3D'width:74.9pt;border:sol=
id windowtext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ус=
ього<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D289 colspan=3D2 valign=3Dbottom style=3D'width:216.95pt;borde=
r:solid windowtext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
цієнти<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:12.25pt'>
  <td width=3D62 valign=3Dbottom style=3D'width:46.55pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n<=
b><o:p></o:p></b></span></p>
  </td>
  <td width=3D227 valign=3Dbottom style=3D'width:170.4pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ча=
стка пацієнтів,
  які відповіли на лікування (95&nbsp;% ДІ)<sup>a</sup><b><o:p></o:p></b></=
span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:12.25pt'>
  <td width=3D216 valign=3Dbottom style=3D'width:162.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm 5.65pt;height:12.25pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА<o:p></o:p></span>=
</p>
  </td>
  <td width=3D100 valign=3Dbottom style=3D'width:74.9pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  </td>
  <td width=3D62 valign=3Dbottom style=3D'width:46.55pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
<o:p></o:p></span></p>
  </td>
  <td width=3D227 valign=3Dbottom style=3D'width:170.4pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
536
  (0,396</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,675=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:22.7pt'>
  <td width=3D216 valign=3Dbottom style=3D'width:162.0pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Компоненти повної відповіді ТМА<o:p><=
/o:p></span></p>
  </td>
  <td width=3D100 valign=3Dtop style=3D'width:74.9pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D62 valign=3Dtop style=3D'width:46.55pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D227 valign=3Dtop style=3D'width:170.4pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:12.5pt'>
  <td width=3D216 valign=3Dtop style=3D'width:162.0pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm 10.2pt;height:12.5pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Нормалізація кількості тромбоцитів<o:=
p></o:p></span></p>
  </td>
  <td width=3D100 valign=3Dtop style=3D'width:74.9pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  </td>
  <td width=3D62 valign=3Dtop style=3D'width:46.55pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>47=
<o:p></o:p></span></p>
  </td>
  <td width=3D227 valign=3Dtop style=3D'width:170.4pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
839
  (0,734</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,944=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:13.7pt'>
  <td width=3D216 valign=3Dbottom style=3D'width:162.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm 10.2pt;height:13.7pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Нормалізація активності ЛДГ<o:p></o:p=
></span></p>
  </td>
  <td width=3D100 valign=3Dbottom style=3D'width:74.9pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  </td>
  <td width=3D62 valign=3Dbottom style=3D'width:46.55pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>43=
<o:p></o:p></span></p>
  </td>
  <td width=3D227 valign=3Dbottom style=3D'width:170.4pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
768
  (0,648</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,887=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:24.0pt'>
  <td width=3D216 valign=3Dbottom style=3D'width:162.0pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm 10.2pt;height:24.0pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Покращення рівня креатиніну в сироват=
ці крові
  на &#8805;&nbsp;25&nbsp;% від вихідного рівня<o:p></o:p></span></p>
  </td>
  <td width=3D100 valign=3Dtop style=3D'width:74.9pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:24.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  </td>
  <td width=3D62 valign=3Dtop style=3D'width:46.55pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:24.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>33=
<o:p></o:p></span></p>
  </td>
  <td width=3D227 valign=3Dtop style=3D'width:170.4pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:24.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
589
  (0,452</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,727=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;mso-yfti-lastrow:yes;height:14.9pt'>
  <td width=3D216 valign=3Dtop style=3D'width:162.0pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm 5.65pt;height:14.9pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:5.75pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Нормалізація гематологічних показникі=
в<o:p></o:p></span></p>
  </td>
  <td width=3D100 valign=3Dtop style=3D'width:74.9pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>56=
<o:p></o:p></span></p>
  </td>
  <td width=3D62 valign=3Dtop style=3D'width:46.55pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>41=
<o:p></o:p></span></p>
  </td>
  <td width=3D227 valign=3Dtop style=3D'width:170.4pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
732
  (0,607</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,857=
)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ДІ — довірчий інтервал, ЛДГ —
лактатдегідрогеназа, ТМА — тромботична мікроангіопатія.<o:p></o:p></span></=
p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>а</span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>95 % ДІ для цієї частки пацієнтів базув=
алися
на методі асимптотичної гаусівської апроксимації з поправкою на безперервні=
сть.<span
style=3D'mso-spacerun:yes'>  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА спостеріг=
алася в
шести додаткових пацієнтів протягом періоду подовження в дні 169, 302, 401,=
 407,
1247 і 1359, що зумовило загальну повну відповідь ТМА у 36 з 56 пацієнтів (=
64,3
%; 95 % ДІ: 50,8&nbsp;%; 77,7&nbsp;%). Кількість пацієнтів, у яких
спостерігалася відповідь за окремими компонентами, збільшилася: до 48 (85,7=
&nbsp;%;
95&nbsp;% ДІ: 75,7&nbsp;%; 95,8&nbsp;%) осіб – за нормалізацією кількості
тромбоцитів, до 49 (87,5&nbsp;%; 95&nbsp;% ДІ: 77,9&nbsp;%; 97,1&nbsp;%) ос=
іб</span><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>–</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>за нормалізацією активності Л=
ДГ і до 37
(66,1&nbsp;%; 95&nbsp;% ДІ: 52,8&nbsp;%; 79,4&nbsp;%) осіб – за поліпшенням
функції нирок.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана часу до досягнення по=
вної
відповіді ТМА становила 86 днів (від 7 до 1359 днів). Швидке збільшення
середньої кількості тромбоцитів спостерігалося після початку застосування
равулізумабу з підвищенням зі 118,52&nbsp;&times;&nbsp;10<sup>9</sup>/л на
вихідному рівні до 243,54&nbsp;&times;&nbsp;10<sup>9</sup>/л на 8 день та
зберігалось вище 227&nbsp;&times;&nbsp;10<sup>9</sup>/л під час усіх наступ=
них
візитів у період первинної оцінки (26 тижнів). Схожим чином середнє значення
активності ЛДГ знизилося від вихідного рівня протягом перших 2 місяців
лікування і підтримувалося протягом періоду первинної оцінки (26 тижнів).<o=
:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У понад двох третин пацієнтів=
, які на
початку дослідження мали переважно 4 або 5 стадію ХХН, на 743 день дослідже=
ння
спостерігали покращення стадії ХХН на 1 або більше стадію. Покращення функц=
ії
нирок, виміряне за допомогою рШКФ, залишалося стабільним до кінця досліджен=
ня<span
style=3D'mso-bidi-font-style:italic'>. Позитивна динаміка стадій ХХН зберіг=
алася у
багатьох пацієнтів (19/30)</span> після досягнення повної відповіді ТМА в х=
оді
26-тижневого періоду первинної оцінки. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>З 27 пацієнтів, які не потреб=
ували
діалізу на початку дослідження, 19 пацієнтів не отримували діаліз протягом
усього періоду дослідження, а 8 пацієнтів розпочали діаліз під час дослідже=
ння,
причому 2 з цих пацієнтів припинили діаліз під час дослідження. Один з
пацієнтів, який припинив діаліз під час додаткового періоду дослідження, по=
тім
відновив лікування і продовжував отримувати діаліз до кінця дослідження.<o:=
p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 5 <span style=3D'mso-tab-count:1'>  =
   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Результати вторинних кінцевих=
 точок
ефективності за 26-тижневий період первинної оцінки в дослідженні
ALXN1210-aHUS-311</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;
mso-fareast-language:EN-US;mso-bidi-language:EN-US'><o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'border-collapse:collapse;border:none;mso-border-alt:solid windowt=
ext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:24.25pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border:solid windowt=
ext 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:24.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметри<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dbottom style=3D'width:293.3pt;border=
:solid windowtext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  24.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>До=
слідження
  ALXN1210-aHUS-311<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;56)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гематологічні показники при=
 ТМА,
  183 день<o:p></o:p></span></p>
  </td>
  <td width=3D193 valign=3Dbottom style=3D'width:144.45pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Сп=
остережуване&nbsp;значення
  (n =3D 48)<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dbottom style=3D'width:148.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
іна від
  вихідного рівня <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(n=
 =3D 48)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тромбоцити (10<sup>9</sup>/=
л)<o:p></o:p></span></p>
  </td>
  <td width=3D193 valign=3Dtop style=3D'width:144.45pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D198 valign=3Dtop style=3D'width:148.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D193 valign=3Dbottom style=3D'width:144.45pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>23=
7,96
  (73,528)<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dbottom style=3D'width:148.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
4,79
  (105,568)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D193 valign=3Dtop style=3D'width:144.45pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>23=
2,00<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dtop style=3D'width:148.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
5,00<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ (Од/л) у сир=
оватці
  крові<o:p></o:p></span></p>
  </td>
  <td width=3D193 valign=3Dtop style=3D'width:144.45pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D198 valign=3Dtop style=3D'width:148.85pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D193 valign=3Dbottom style=3D'width:144.45pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19=
4,46
  (58,099)<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dbottom style=3D'width:148.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-5=
19,83
  (572,467)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:31.95pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:31.95pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D193 valign=3Dtop style=3D'width:144.45pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:31.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>17=
6,50<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D198 valign=3Dtop style=3D'width:148.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:31.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-3=
10,75<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:34.0pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Підвищення рівня гемоглобін=
у на &#8805;&nbsp;20&nbsp;г/л
  від вихідного рівня з підтверджувальним результатом під час періоду перви=
нної
  оцінки<o:p></o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dtop style=3D'width:293.3pt;border-to=
p:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:9.85pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:9.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n/m<o:p></o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dtop style=3D'width:293.3pt;border:no=
ne;
  border-right:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .=
25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-top-alt:solid windo=
wtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:9.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40=
/56<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:11.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>частка (95&nbsp;% ДІ)*<o:p>=
</o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dbottom style=3D'width:293.3pt;border=
-top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
714
  (0,587</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,842=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зміна від вихідного рівня с=
тадії ХХН,
  183 день<o:p></o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 rowspan=3D2 valign=3Dtop style=3D'width:293.3=
pt;border:
  none;border-right:solid windowtext 1.0pt;mso-border-top-alt:solid windowt=
ext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-top-alt:solid windo=
wtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:8.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.05pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Позитивна динаміка<sup>a</s=
up><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:21.2pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:21.2pt'>
  <p class=3DMsoNormal style=3D'margin-bottom:0cm;margin-bottom:.0001pt;tex=
t-align:
  justify'><span lang=3DEN-GB style=3D'mso-ansi-language:EN-GB'>n/m</span><=
/p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dtop style=3D'width:293.3pt;border:no=
ne;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:21.2pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>32=
/47<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:12.95pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:12.95pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Частка (95&nbsp;% ДІ)*<o:p>=
</o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dbottom style=3D'width:293.3pt;border=
:none;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
681
  (0,529</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,809=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:11.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:11.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Погіршення<sup>б</sup><o:p>=
</o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dtop style=3D'width:293.3pt;border:no=
ne;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:3.3pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:3.3pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DEN-GB style=3D'mso-ansi-language:EN-GB'>n/m</span><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dtop style=3D'width:293.3pt;border:no=
ne;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:3.3pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2/=
13<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:12.5pt'>
  <td width=3D242 valign=3Dbottom style=3D'width:181.45pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 23.55pt;height:12.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Частка (95&nbsp;% ДІ)*<o:p>=
</o:p></span></p>
  </td>
  <td width=3D391 colspan=3D2 valign=3Dbottom style=3D'width:293.3pt;border=
-top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
154
  (0,019</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,454=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:11.35pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ (мл/хв/1,73 м<sup>2</s=
up>),
  183 день<o:p></o:p></span></p>
  </td>
  <td width=3D193 valign=3Dbottom style=3D'width:144.45pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Сп=
остережуване&nbsp;значення
  (n =3D 48)<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dbottom style=3D'width:148.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
іна від
  вихідного рівня <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(n=
 =3D 47)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;height:11.35pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D193 valign=3Dbottom style=3D'width:144.45pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>51=
,83
  (39,162)<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dbottom style=3D'width:148.85pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
,80
  (35,454)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:20;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D242 valign=3Dtop style=3D'width:181.45pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D193 valign=3Dtop style=3D'width:144.45pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40=
,00<o:p></o:p></span></p>
  </td>
  <td width=3D198 valign=3Dtop style=3D'width:148.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>29=
,00<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>—</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>розрахункова швидкість клубоч=
кової
фільтрації, ЛДГ&nbsp;—&nbsp;лактатдегідрогеназа, ТМА</span><span lang=3DEN-=
US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>—</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>тромботична мікроангіопатія, =
n —
кількість пацієнтів із доступними даними для конкретної оцінки, які здійсни=
ли
візит у день 183; m — кількість пацієнтів, які відповідають певному критері=
ю.
Стадія ХХН класифікується на підставі стадій ХХН, визначених Національним ф=
ондом
нирок США. 5 стадія розглядається як найгірша категорія, тоді як 1 стадія
розглядається як найкраща категорія. Початковий рівень отримано на підставі
останнього доступного значення рШКФ перед початком лікування.
Позитивна/негативна динаміка: порівняно зі стадією ХХН на вихідному рівні.<=
o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>*&nbsp;95&nbsp;% ДІ ґрунтують=
ся на
точних довірчих межах з використанням методу Клоппера – Пірсона. <o:p></o:p=
></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>a</span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>&nbsp;За винятком пацієнтів з 1 стадією=
 ХХН
на вихідному рівні, оскільки в них не може бути поліпшення.<o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>б</span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>&nbsp;За винятком пацієнтів із 5 стадіє=
ю ХХН
на вихідному рівні, оскільки в них не може бути погіршення.<o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'font-size:11.0pt;mso-fareast-language:EN-US;mso-bidi-lan=
guage:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Заключний аналіз ефективності дослідження для всіх пацієнтів, які
отримували равулізумаб протягом медіанної тривалості лікування 130,36 тижня,
підтвердив, що відповіді на лікування равулізумабом, які спостерігалися під=
 час
періоду первинної оцінки, зберігалися впродовж усього дослідження.<o:p></o:=
p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Генералізована міастенія грав=
іс (гМГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю дорослих
пацієнтів з гМГ</span></u></i><i><u><span style=3D'mso-bidi-font-size:12.0p=
t;
mso-ansi-language:RU'><o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p><span
 style=3D'text-decoration:none'>&nbsp;</span></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність та безпеку засто=
сування равулізумабу
дорослим пацієнтам з гМГ оцінювали у рандомізованому, подвійно сліпому,
плацебо-контрольованому, багатоцентровому дослідженні 3 фази (дослідження
ALXN1210-MG-306). Пацієнтам, які брали участь у цьому дослідженні, згодом б=
уло
дозволено вступити в період додаткового відкритого лікування, під час якого=
 всі
пацієнти отримували равулізумаб.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти з гМГ (діагностованою
щонайменше 6 місяців тому) з позитивним серологічним тестом на антитіла до
ацетилхолінових рецепторів (АХР) класу II–IV за класифікацією MGFA
(Американський фонд міастенії/Myasthenia Gravis Foundation of America) та з=
і збереженою
симптоматикою, яка підтверджується загальним балом за шкалою Myasthenia Gra=
vis
Activities of Daily Living (MG-ADL/шкала оцінки повсякденної діяльності при
міастенії) &#8805; 6, були рандомізовані для отримання равулізумабу (N =3D =
86)
або плацебо (N =3D 89). Пацієнтам, які отримували імуносупресивну терапію
(кортикостероїди, азатіоприн, циклофосфамід, циклоспорин, метотрексат,
мікофенолату мофетил або такролімус), було дозволено продовжувати терапію
протягом усього дослідження. Крім того, у разі клінічного погіршення стану =
пацієнта,
як це визначено протоколом дослідження, дозволялося проведення невідкладної
терапії (включаючи високі дози кортикостероїдів, ПО/ПФ або в/вІГ).<o:p></o:=
p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загалом 162 (92,6&nbsp;%) пац=
ієнти
завершили 26-тижневий рандомізований контрольований період дослідження ALXN=
1210-MG-306.
Вихідні характеристики пацієнтів наведені в таблиці&nbsp;6. Більшість
(97&nbsp;%) пацієнтів, включених у дослідження, отримували принаймні один в=
ид
імуномодулюючої терапії, включаючи імуносупресанти, плазмообмін/плазмаферез
(ПО/ПФ) або внутрішньовенне введення імуноглобуліну (в/вІГ) протягом останн=
іх
двох років до включення в дослідження.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 6 <span style=3D'mso-tab-count:1'>  =
   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідні характеристики захвор=
ювання в
учасників дослідження ALXN1210-MG-306</span><b><span lang=3DUK style=3D'mso=
-bidi-font-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'><o:p></o:p></spa=
n></b></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:453.8pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:22.7pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметр<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:solid window=
text 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пл=
ацебо<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;89)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:solid window=
text 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;86)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Стать<b><o:p></o:p></b></sp=
an></p>
  </td>
  <td width=3D114 valign=3Dbottom style=3D'width:85.2pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 10.2pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Чоловіча<o:p></o:p></span><=
/p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>44=
 (49,4)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>42=
 (48,8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 10.2pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Жіноча<o:p></o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
 (50,6)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>44=
 (51,2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вік на момент прийому першо=
ї дози
  досліджуваного лікарського засобу (років)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>53=
,3
  (16,05)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>58=
,0
  (13,82)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b=
></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(2=
0, 82)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(1=
9, 79)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:17.5pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:17.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти літнього віку (&#8=
805;
  65&nbsp;років) <br>
  на момент включення в дослідження<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;
  mso-bidi-language:EN-US'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:17.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:17.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
 (27,0)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:17.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
 (34,9)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тривалість захворювання на =
гМГ з
  моменту встановлення діагнозу (роки)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 style=3D'width:85.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D113 style=3D'width:84.7pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
,0
  (8,90)<o:p></o:p></span></p>
  </td>
  <td width=3D115 style=3D'width:86.4pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9,=
8 (9,68)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D114 valign=3Dbottom style=3D'width:85.2pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(0=
,5</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 36,1)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(0=
,5</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 39,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7,=
6<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5,=
7<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідна оцінка за шкалою MG=
-ADL<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dbottom style=3D'width:85.2pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8,=
9 (2,30)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9,=
1 (2,62)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b=
></p>
  </td>
  <td width=3D114 valign=3Dbottom style=3D'width:85.2pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(6=
,0</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 15,0)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(6=
,0</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:30.85pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:30.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b=
></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:30.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:30.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9,=
0<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:30.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9,=
0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідна оцінка за шкалою QM=
G<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
,5
  (5,26)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
,8
  (5,21)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b=
></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(2=
,0</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 27,0)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(6=
,0</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 39,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:26.65pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:26.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b=
></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
,0<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:11.35pt'>
  <td width=3D263 valign=3Dtop style=3D'width:197.5pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вихідний клас за класифікац=
ією MGFA<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клас II (легка слабкість)<b=
><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>39=
 (44)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>39=
 (45)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клас III (помірна слабкість=
)</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;
  mso-bidi-language:EN-US'><o:p></o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
 (51)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>41=
 (48)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клас IV (сильна слабкість)<=
/span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;
  mso-bidi-language:EN-US'><o:p></o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(6)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>6 =
(7)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:20;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Будь-який попередній випадок
  інтубації з моменту встановлення діагнозу (клас V за класифікацією MGFA)<=
b><o:p></o:p></b></span></p>
  </td>
  <td width=3D114 style=3D'width:85.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 style=3D'width:84.7pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9 =
(10,1)<o:p></o:p></span></p>
  </td>
  <td width=3D115 style=3D'width:86.4pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(9,3)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:21;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів із попе=
реднім
  міастенічним кризом із моменту встановлення діагнозу<sup>a</sup><b><o:p><=
/o:p></b></span></p>
  </td>
  <td width=3D114 style=3D'width:85.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 style=3D'width:84.7pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>17=
 (19,1)<o:p></o:p></span></p>
  </td>
  <td width=3D115 style=3D'width:86.4pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>21=
 (24,4)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:22;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість проведень стабіль=
ної
  імуносупресивної терапії<sup>б</sup> на момент включення в дослідження<b>=
<o:p></o:p></b></span></p>
  </td>
  <td width=3D114 style=3D'width:85.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D113 style=3D'width:84.7pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D115 style=3D'width:86.4pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:23;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0<b><o:p></o:p></b></span><=
/p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(9,0)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
 (11,6)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:24;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border-top:none;bo=
rder-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1<b><o:p></o:p></b></span><=
/p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:84.7pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>34=
 (38,2)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dbottom style=3D'width:86.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40=
 (46,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:25;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D263 valign=3Dbottom style=3D'width:197.5pt;border:solid windo=
wtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  class=3DSimSun><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-fa=
mily:"Times New Roman",serif'>&#8805;
  </span></span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2<o:p><=
/o:p></span></p>
  </td>
  <td width=3D114 valign=3Dtop style=3D'width:85.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:84.7pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>47=
 (52,8)<o:p></o:p></span></p>
  </td>
  <td width=3D115 valign=3Dtop style=3D'width:86.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>36=
 (41,9)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Макс. — максимальне значення;=
 мін. —
мінімальне значення; MG-ADL — Myasthenia Gravis Activities of Daily Living
(шкала оцінки повсякденної діяльності при міастенії); MGFA</span><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>—</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Myasthenia Gravis Foundation =
of
America (Американський фонд міастенії); QMG</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>—</span><span lang=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span><s=
pan
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Quantitative Myasthenia Gravi=
s (шкала
кількісної оцінки тяжкості клінічних проявів міастенії); СВ — стандартне
відхилення.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>а</span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>&nbsp;Інформація про попередні міастені=
чні
кризи збиралася як частина історії хвороби та не оцінювалася згідно з
визначенням клінічного протоколу.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>б</span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>&nbsp;Імуносупресивна терапія включає
кортикостероїди, азатіоприн, циклофосфамід, циклоспорин, метотрексат,
мікофенолату мофетил або такролімус.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Первинною кінцевою точкою бул=
а зміна
загальної оцінки за шкалою MG-ADL від вихідного рівня до 26-го тижня.<o:p><=
/o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вторинні кінцеві точки, які т=
акож
оцінювали зміни від вихідного рівня до 26-го тижня, включали зміну загальної
оцінки за шкалою кількісної оцінки тяжкості клінічних проявів міастенії (QM=
G),
частку пацієнтів із позитивною динамікою щонайменше на 5 та 3 бали у загаль=
ній
оцінці за шкалами QMG та MG-ADL відповідно, а також зміни оцінки якості жит=
тя.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб продемонстрував
статистично значущу зміну загальної оцінки за шкалою MG-&nbsp;ADL порівняно=
 з
плацебо. Результати первинних та вторинних кінцевих точок наведено в таблиц=
і 7.</span><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p></o:p></span>=
</p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p>&nbsp;</o:p><=
/span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 7<span
style=3D'mso-tab-count:1'>      </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Аналіз первинної та вторинної
кінцевих точок ефективності<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D661
 style=3D'width:496.0pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm 5.65pt 0cm 5.65pt;mso-border-i=
nsideh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:58.1pt'>
  <td width=3D113 valign=3Dtop style=3D'width:84.9pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кінцеві точки ефективності =
<br>
  на&nbsp;26-му тижні<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пл=
ацебо <br>
  (N =3D 89)<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення, розрахова-не за МНК (СПС)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D97 valign=3Dtop style=3D'width:72.95pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб
  (N =3D 86)<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення, розрахова-не за МНК (СПС)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D101 valign=3Dtop style=3D'width:75.95pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистич-ні
  дані для порівняння<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Еф=
ект
  лікування,<br>
  95 % ДІ<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:58.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>p-=
значення
  <br>
  (використання моделі&nbsp;зі змішаними ефектами повторних вимірювань)<b><=
o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:34.0pt'>
  <td width=3D113 valign=3Dtop style=3D'width:84.9pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>MG-ADL<o:p></o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-1=
,4
  (0,37)<o:p></o:p></span></p>
  </td>
  <td width=3D97 valign=3Dtop style=3D'width:72.95pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-3=
,1
  (0,38)<o:p></o:p></span></p>
  </td>
  <td width=3D101 valign=3Dtop style=3D'width:75.95pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рі=
зниця у
  змінах порівняно <br>
  з вихідним рівнем<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-1=
,6 (-2,6</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-0=
,7)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
0009<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:34.0pt'>
  <td width=3D113 valign=3Dtop style=3D'width:84.9pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>QMG<o:p></o:p></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-0=
,8
  (0,45)<o:p></o:p></span></p>
  </td>
  <td width=3D97 valign=3Dtop style=3D'width:72.95pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-2=
,8
  (0,46)<o:p></o:p></span></p>
  </td>
  <td width=3D101 valign=3Dtop style=3D'width:75.95pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рі=
зниця у
  змінах порівняно <br>
  з вихідним рівнем<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-2=
,0 (-3,2</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-0=
,8)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
0009<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:34.0pt'>
  <td width=3D113 valign=3Dtop style=3D'width:84.9pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>MG-QoL15r<o:p></o:p></span>=
</p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-1=
,6
  (0,70)<o:p></o:p></span></p>
  </td>
  <td width=3D97 valign=3Dtop style=3D'width:72.95pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-3=
,3
  (0,71)<o:p></o:p></span></p>
  </td>
  <td width=3D101 valign=3Dtop style=3D'width:75.95pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рі=
зниця у
  змінах порівняно <br>
  з вихідним рівнем<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-1=
,7 (-3,4</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,1)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
0636<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;mso-yfti-lastrow:yes;height:34.0pt'>
  <td width=3D113 valign=3Dtop style=3D'width:84.9pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Neuro-QoL-fatigue<o:p></o:p=
></span></p>
  </td>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-4=
,8
  (1,87)<o:p></o:p></span></p>
  </td>
  <td width=3D97 valign=3Dtop style=3D'width:72.95pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-7=
,0
  (1,92)<o:p></o:p></span></p>
  </td>
  <td width=3D101 valign=3Dtop style=3D'width:75.95pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рі=
зниця у
  змінах порівняно <br>
  з вихідним рівнем<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-2=
,2 (-6,9</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 2,6)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
3734</span><!--[if supportFields]><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF _Ref167176338 \r \h<span style=3D'mso-spacerun:yes'>  </span>\* MERGE=
FORMAT
  <span style=3D'mso-element:field-separator'></span></span></sup><![endif]=
--><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>a<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F0052=
00650066003100360037003100370036003300330038000000</w:data>
  </xml><![endif]--></span></sup><!--[if supportFields]><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></sup><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167176338"><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>=
ДІ —
довірчий інтервал; МНК — метод найменших квадратів; MG-ADL — Myasthenia Gra=
vis
Activities of Daily Living (шкала оцінки повсякденної діяльності при
міастенії); MG-QoL15r</span></a><span style=3D'mso-bookmark:_Ref167176338'>=
<span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>—</span></span><span style=3D'mso-bookmark:_Ref167176338'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>переглянута шкала якості життя при міастенії, яка складається з 15
пунктів; Neuro-</span></span><span style=3D'mso-bookmark:_Ref167176338'><sp=
an
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>QoL-</span></span><span style=3D'mso-bookmark:_Ref167176338'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>fatigue — Neurological Quality of Life Fatigue (шкала оцінки якості
життя, пов’язана зі втомлюваністю, при неврологічних захворюваннях); QMG</s=
pan></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;mso-ansi-language:EN-US'>&nbsp;</span></span><span style=3D'mso-book=
mark:
_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>—</span>=
</span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DEN-US style=3D'mso-bidi-f=
ont-size:
12.0pt;mso-ansi-language:EN-US'>&nbsp;</span></span><span style=3D'mso-book=
mark:
_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Quantita=
tive
Myasthenia Gravis (шкала кількісної оцінки тяжкості клінічних проявів
міастенії); СПС</span></span><span style=3D'mso-bookmark:_Ref167176338'><sp=
an
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>—</span></span><span style=3D'mso-bookmark:_Ref167176338'><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span></span><span
style=3D'mso-bookmark:_Ref167176338'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>стандартна похибка середнього.<o:p></o:p></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Ref167176338'><sup><span lang=3DUK style=3D'mso-bidi=
-font-size:
12.0pt'>а</span></sup></span><span style=3D'mso-bookmark:_Ref167176338'><sp=
an
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> Кінцева точка не була формал=
ьно
перевірена на статистичну значущість; повідомлялося про номінальне р-значен=
ня.</span></span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У дослідженні ALXN1210-MG-306
клінічна відповідь за загальною оцінкою за шкалою MG-ADL визначалася як
покращення щонайменше на 3 бали. Частка клінічних відповідей на 26-му тижні
становила 56,7&nbsp;% у групі равулізумабу порівняно з 34,1&nbsp;% у групі
плацебо (номінальне значення р =3D 0,0049). Клінічна відповідь за загальною
оцінкою за шкалою QMG визначалася як покращення щонайменше на 5 балів. Част=
ка
клінічних відповідей на 26-му тижні становила 30,0&nbsp;% у групі равулізум=
абу
порівняно з 11,3&nbsp;% у групі плацебо (номінальне значення р =3D 0,0052).=
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 8 представлено інфо=
рмацію
щодо пацієнтів із клінічним погіршенням і пацієнтів, які потребували
невідкладної терапії, протягом 26-тижневого рандомізованого контрольованого
періоду. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 8 <span style=3D'mso-tab-count:1'>  =
   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клінічне погіршення та невідк=
ладна
терапія<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D652
 style=3D'width:488.9pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:25.5pt'>
  <td width=3D368 style=3D'width:276.3pt;border:solid windowtext 1.0pt;mso-=
border-alt:
  solid windowtext .25pt;background:white;padding:2.85pt 5.65pt 0cm 5.65pt;
  height:25.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
інна<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D123 style=3D'width:92.1pt;border:solid windowtext 1.0pt;borde=
r-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:2.85pt .5pt 0cm .5pt;height:25.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D76 style=3D'width:2.0cm;border:solid windowtext 1.0pt;border-=
left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:2.85pt .5pt 0cm .5pt;height:25.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пл=
ацебо<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;89)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D85 style=3D'width:63.8pt;border:solid windowtext 1.0pt;border=
-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:2.85pt .5pt 0cm .5pt;height:25.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб
  <br>
  (N =3D 86)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:14.15pt'>
  <td width=3D368 valign=3Dtop style=3D'width:276.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальна кількість пацієнті=
в із
  клінічним погіршенням<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D76 valign=3Dtop style=3D'width:2.0cm;border-top:none;border-l=
eft:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
 (16,9)<o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(9,3)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;mso-yfti-lastrow:yes;height:14.15pt'>
  <td width=3D368 valign=3Dtop style=3D'width:276.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальна кількість пацієнті=
в, які
  потребують невідкладної терапії</span><!--[if supportFields]><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF Rescue_therapy \h <span style=3D'mso-spacerun:yes'> </span>\* MERGEFO=
RMAT <span
  style=3D'mso-element:field-separator'></span></span></sup><![endif]--><su=
p><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>a<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000F000000520065=
0073006300750065005F0074006800650072006100700079000000</w:data>
  </xml><![endif]--></span></sup><!--[if supportFields]><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></sup><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D76 valign=3Dtop style=3D'width:2.0cm;border-top:none;border-l=
eft:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
 (15,7)<o:p></o:p></span></p>
  </td>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(9,3)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"Rescue_therapy"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12=
.0pt'>a</span></sup></a><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> </span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>Невідкладна терапія включала високі дози
кортикостероїдів, плазмообмін/плазмаферез або внутрішньовенне введення
імуноглобуліну.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У пацієнтів, які спочатку отр=
имували
Ультоміріс під час рандомізованого контрольованого періоду та продовжували
отримувати Ультоміріс до 164 тижнів періоду додаткового відкритого лікуванн=
я,
ефект лікування продовжував бути стійким (рисунок 3). У пацієнтів, які споч=
атку
отримували плацебо протягом 26-тижневого рандомізованого контрольованого
періоду та розпочали лікування лікарським засобом Ультоміріс протягом періо=
ду
додаткового відкритого лікування, спостерігалася швидка та стійка відповідь=
 на лікування
за всіма кінцевими точками, включно з оцінками за шкалами MG-ADL та QMG (ри=
сунок
3), протягом медіанної тривалості лікування, що становила приблизно 2 роки.=
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DEN-US style=3D'mso-ansi-language:EN-US;mso-fareast-language:EN-US;
mso-bidi-language:AR-SA;layout-grid-mode:both;mso-no-proof:yes'><v:shape id=
=3D"_x0000_i1027"
 type=3D"#_x0000_t75" alt=3D"A graph showing the number of objects&#10;&#10=
;AI-generated content may be incorrect."
 style=3D'width:402.75pt;height:317.25pt;visibility:visible'>
 <v:imagedata src=3D"UA212780101_35E4.files/image003.jpg" o:title=3D"A grap=
h showing the number of objects&#10;&#10;AI-generated content may be incorr=
ect"/>
</v:shape></span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-=
ansi-language:
EN-US'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ДІ — довірчий інтервал; MG-AD=
L —
Myasthenia Gravis Activities of Daily Living (шкала оцінки повсякденної
діяльності при міастенії); QMG — Quantitative Myasthenia Gravis (шкала
кількісної оцінки тяжкості клінічних проявів міастенії).<o:p></o:p></span><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Примітка. Показники рандомізо=
ваного
контрольованого періоду базуються на даних 175 пацієнтів. Показники додатко=
вого
періоду відкритого лікування базуються на даних 161 пацієнта.<o:p></o:p></s=
pan></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Рис. 3. </span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>З=
міна від
вихідного рівня протягом рандомізованого контрольованого періоду в загальній
оцінці за шкалою MG-ADL (A) та загальній оцінці за шкалою QMG (B) до 164 ти=
жня
(середнє значення та 95&nbsp;% ДІ)<b style=3D'mso-bidi-font-weight:normal'>=
 </b></span><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'><o:p></o:p></spa=
n></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У період додаткового відкрито=
го
лікування у дослідженні лікарі мали можливість коригувати імуносупресивну
терапію. Наприкінці додаткового періоду відкритого лікування (медіанна
тривалість лікування лікарським засобом Ультоміріс як у рандомізований
контрольний період, так і в додатковий період відкритого лікування становила
759 днів) 30,1&nbsp;% <span style=3D'mso-spacerun:yes'> </span>пацієнтів зм=
еншили
добову дозу терапії кортикостероїдами, а 12,4&nbsp;% пацієнтів припинили
терапію кортикостероїдами. Найчастішою причиною зміни терапії кортикостерої=
дами
було послаблення симптомів міастенії на фоні лікування равулізумабом.<o:p><=
/o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Оптиконевромієліт з розладом =
спектру
(ОНМРС)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю дорослих
пацієнтів із ОНМРС<o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність равулізумабу для=
 дорослих
пацієнтів з ОНМРС з позитивним результатом тесту на антитіла до AQP4 оцінюв=
али
у глобальному відкритому клінічному дослідженні (дослідження ALXN1210-NMO-3=
07).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У дослідження ALXN1210-NMO-30=
7 було
включено 58 дорослих пацієнтів з ОНМРС, які мали позитивний серологічний те=
ст
на антитіла до AQP4, принаймні 1 рецидив за останні 12 місяців до початку
скринінгового періоду та оцінку за Розширеною шкалою інвалідизації (EDSS)
&#8804;</span><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi-font-s=
ize:12.0pt;
font-family:"Times New Roman",serif'>&nbsp;</span></span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>7&nbsp;балів. Попереднє проведення
імуносупресивної терапії (ІСТ) не було обов’язковим для включення в
дослідження, і 53,4&nbsp;% пацієнтів отримували монотерапію равулізумабом.
Пацієнтам, які отримували окремі ІСТ (тобто кортикостероїди, азатіоприн,
мікофенолату мофетил, такролімус), було дозволено продовжувати терапію в
комбінації з равулізумабом з вимогою стабільного прийому лікарського засобу=
 до
досягнення ними 106-го тижня дослідження. Крім того, була дозволена інтенси=
вна
терапія для лікування рецидиву (включаючи високі дози кортикостероїдів, ПО/=
ПФ
та в/вІГ), якщо в пацієнта стався рецидив під час дослідження.<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середній вік пацієнтів, включ=
ених у
дослідження, становив 47,4 року (від 18 до 74 років), більшість із них були
жінками (90&nbsp;%). Середній вік при первинній клінічній маніфестації ОНМРС
становив 42,5 року і варіював від 16 до 73 років. Вихідні характеристики
захворювання наведено в таблиці 9.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 9 <span
style=3D'mso-tab-count:1'>     </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анамнез та вихідні характерис=
тики
захворювання в учасників дослідження ALXN1210&#8209;NMO&#8209;307<o:p></o:p=
></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D652
 style=3D'width:488.9pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:39.1pt'>
  <td width=3D378 style=3D'width:283.35pt;border:solid windowtext 1.0pt;mso=
-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  39.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
9.35pt;
  margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:center=
'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Змінна<b><o:p></o:p></b></s=
pan></p>
  </td>
  <td width=3D132 style=3D'width:99.25pt;border:solid windowtext 1.0pt;bord=
er-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:39.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D142 style=3D'width:106.3pt;border:solid windowtext 1.0pt;bord=
er-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:39.1pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>До=
слідження
  ALXN1210-NMO-307 <br>
  Равулізумаб<br>
  (N =3D 58)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:13.05pt'>
  <td width=3D378 rowspan=3D3 valign=3Dtop style=3D'width:283.35pt;border:s=
olid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Час від початкового клінічного прояву=
 ОНМРС
  до прийому першої дози досліджуваного лікарського засобу (роки)<o:p></o:p=
></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5,=
2 (6,38)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2,=
0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
н.,
  макс.<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
19</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 24,49<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:13.05pt'>
  <td width=3D378 rowspan=3D3 valign=3Dtop style=3D'width:283.35pt;border:s=
olid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Показник РЧР в анамнезі протягом 24 м=
ісяців
  до скринінгу<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1,=
87
  (1,59)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1,=
44<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
н.,
  макс.<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
5</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 6,9<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:13.05pt'>
  <td width=3D378 rowspan=3D3 valign=3Dtop style=3D'width:283.35pt;border:s=
olid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Вихідна оцінка за шкалою HAI<o:p></o:=
p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1,=
2 (1,42)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1,=
0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:13.05pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
н.,
  макс.<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
7<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:23.25pt'>
  <td width=3D378 rowspan=3D3 valign=3Dtop style=3D'width:283.35pt;border:s=
olid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  23.25pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Вихідна оцінка за шкалою EDSS<o:p></o=
:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Се=
реднє
  значення (СВ)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:23.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3,=
30
  (1,58)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:13.3pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.3pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.3pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3,=
25<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:13.3pt'>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.3pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
н.,
  макс.<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.3pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
0</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 7,0<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:11.45pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.45pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Будь-який прийом ритуксимабу в анамне=
зі<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.45pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.45pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>21=
 (36,2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:26.35pt'>
  <td width=3D378 style=3D'width:283.35pt;border:solid windowtext 1.0pt;bor=
der-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.35pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, які отримували
  стабільні кортикостероїди тільки на момент включення в дослідження<o:p></=
o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:26.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:26.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
 (19,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;mso-yfti-lastrow:yes;height:24.95pt'>
  <td width=3D378 style=3D'width:283.35pt;border:solid windowtext 1.0pt;bor=
der-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:24.95pt'>
  <p class=3DMsoNormal style=3D'margin-top:0cm;margin-right:9.35pt;margin-b=
ottom:
  0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify'><span lang=
=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, які не отримувал=
и жодної
  ІСТ на момент включення в дослідження<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.25pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:24.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:24.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>31=
 (53,4)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>РЧР — річна частота рецидивів=
; EDSS —
Expanded Disability Status Scale (розширена шкала інвалідизації); HAI — Hau=
ser
Ambulation Index (індекс ходьби Хаузера); ІСТ&nbsp;— імуносупресивна терапі=
я;
макс. — максимальне значення; мін. — мінімальне значення; ОНМРС — оптиконев=
ромієліт
з розладом спектру; СВ — стандартне відхилення.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Первинною кінцевою точкою дос=
лідження
ALXN1210-NMO-307 був час до першого діагностованого рецидиву під час
дослідження, визначений незалежною експертною комісією. У пацієнтів, які
отримували лікування равулізумабом, протягом періоду первинного лікування не
було зафіксовано жодного рецидиву. Усі пацієнти, які отримували лікування
равулізумабом, не мали рецидивів протягом медіани спостереження 90,93 тижня.
Пацієнти, які отримували лікування равулізумабом, мали стійкий результат без
рецидивів за первинною кінцевою точкою з супутньою ІСТ або без неї.<o:p></o=
:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK>У заключному аналізі ефективності із середнім періодом спостереже=
ння
170,29&nbsp;тижня у пацієнтів, які отримували равулізумаб, до кінця дослідж=
ення
не було зафіксовано жодного підтвердженого рецидиву. Відповіді на лікування
равулізумабом, які спостерігалися під час періоду первинної оцінки, зберіга=
лися
протягом усього дослідження. Крім того, із 27 пацієнтів, які на вихідному р=
івні
отримували імуносупресивну терапію, 17 (63&nbsp;%) пацієнтам було зменшено =
дозу
або припинено застосування принаймні одного препарату імуносупресивної тера=
пії
під час лікування равулізумабом.</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Не вивчали застосування равул=
ізумабу для
інтенсивного лікування рецидивів у пацієнтів із ОНМРС.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Педіатрична популяція <o:p></=
o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пароксизмальна нічна гемоглоб=
інурія
(ПНГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю пацієнт=
ів
дитячого віку з ПНГ (дослідження ALXN1210-PNH-304)<o:p></o:p></span></u></i=
></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю пацієнт=
ів
дитячого віку (ALXN1210-PNH-304) є багатоцентровим відкритим дослідженням 3
фази, проведеним за участю дітей з ПНГ, які раніше отримували лікування
екулізумабом і раніше не отримували інгібітори комплементу.<o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Згідно з результатами проміжн=
ого
аналізу загалом 13 пацієнтів дитячого віку з ПНГ завершили лікування
равулізумабом протягом періоду первинної оцінки (26 тижнів) дослідження
ALXN1210-PNH-304. 5 із 13 пацієнтів раніше не отримували лікування інгібіто=
ром
комплементу, а 8 пацієнтів отримували лікування екулізумабом до включення в
дослідження.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Більшість пацієнтів були віко=
м від 12
до 17 років на момент проведення першої інфузії (середній вік 14,4 року), п=
ри
цьому 2 пацієнти були віком до 12 років (11 років і 9 років). 8 із 13 паціє=
нтів
були жіночої статі. Середня вихідна маса тіла становила 56&nbsp;кг, діапазон
від 37 до 72&nbsp;кг. У таблиці 10 представлено анамнез захворювання та вих=
ідні
характеристики пацієнтів дитячого віку, включених у дослідження ALXN1210
PNH-304.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 10 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анамнез захворювання та вихід=
ні
характеристики пацієнтів дитячого віку (повна вибірка для аналізу)<o:p></o:=
p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D671
 style=3D'width:503.0pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .5pt;
 mso-border-top-alt:solid windowtext .25pt;mso-table-overlap:never;mso-padd=
ing-alt:
 0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid windowtext;mso-border-ins=
idev:
 .25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:34.0pt'>
  <td width=3D387 style=3D'width:290.35pt;border:solid windowtext 1.0pt;mso=
-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
інна<o:p></o:p></span></p>
  </td>
  <td width=3D142 style=3D'width:106.3pt;border:solid windowtext 1.0pt;bord=
er-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
цієнти,
  які ніколи не отримували лікування інгібітором комплементу<b><o:p></o:p><=
/b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;5)<o:p></o:p></span></p>
  </td>
  <td width=3D142 style=3D'width:106.35pt;border:solid windowtext 1.0pt;bor=
der-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
цієнти,&nbsp;які
  отримували лікування екулізумабом<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальний розмір клону ПНГ в
  еритроцитах (%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;4)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;6)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана (мін., макс.)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40=
,05 (6,9</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 68,1)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>71=
,15
  (21,2</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ans=
i-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 85,4)=
<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальний розмір клону ПНГ в
  гранулоцитах (%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана (мін., макс.)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>78=
,30
  (36,8</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ans=
i-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 99,0)=
<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>91=
,60
  (20,3</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ans=
i-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 97,6)=
<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:22.7pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, які пе=
ренесли
  переливання еритроцитарної маси / цільної крові протягом 12&nbsp;місяців =
до
  введення першої дози, n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(40,0)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;mso-border-right-alt:solid windowte=
xt .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(25,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:22.7pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість переливань еритро=
цитарної
  маси / цільної крові протягом 12 місяців до введення першої дози <o:p></o=
:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.35pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Усього<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2<=
o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана (мін., макс.)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5,=
0 (4</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 6)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1,=
0 (1</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 1)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:22.7pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість одиниць еритроцит=
арної
  маси / цільної крові, перелитої протягом 12 місяців до введення першої до=
зи<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;mso-border-right-alt:solid windowte=
xt .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:11.05pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:11.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Усього<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:11.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>14=
<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2<=
o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:10.8pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:10.8pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана (мін., макс.)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:10.8pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7,=
0 (3</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 11)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:10.8pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2,=
0 (2</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 2)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:24.7pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:24.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти з будь-якими прояв=
ами ПНГ
  до отримання інформованої згоди, n (%)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:24.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(100)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:24.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(100)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:8.5pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анемія<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(40,0)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(62,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:8.5pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гематурія чи гемоглобінурія=
<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(40,0)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(62,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:8.5pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Апластична анемія<o:p></o:p=
></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3 =
(60,0)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(12,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:8.5pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ниркова недостатність<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(40,0)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(25,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:5.65pt'>
  <td width=3D387 valign=3Dtop style=3D'width:290.35pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 11.35pt;height:5.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інше</span><!--[if supportF=
ields]><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF _Ref167181240 \r \h<span style=3D'mso-spacerun:yes'>  </span>\* MERGE=
FORMAT
  <span style=3D'mso-element:field-separator'></span></span></sup><![endif]=
--><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F0052=
00650066003100360037003100380031003200340030000000</w:data>
  </xml><![endif]--></span></sup><!--[if supportFields]><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></sup><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:5.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0<=
o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:5.65pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(12,5)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:8.5pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ до лікування=
<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D387 valign=3Dbottom style=3D'width:290.35pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .25pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 11.35pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана (мін., макс.)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>58=
8,50
  (444</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi=
-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 2269,=
7)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>25=
1,50
  (140,5</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 487)<=
o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167181240"><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>=
ЛДГ —
лактатдегідрогеназа, макс. — максимальне значення, мін. — мінімальне значен=
ня,
ПНГ — пароксизмальна нічна гемоглобінурія, pRBC — еритроцитарна маса;
RBC&nbsp;—</span></a><span style=3D'mso-bookmark:_Ref167181240'><span lang=
=3DEN-US
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&nbsp;</span></=
span><span
style=3D'mso-bookmark:_Ref167181240'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>еритроцити.<o:p></o:p></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Ref167181240'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>Примітка. Відсоткове співвідношення засноване на загальній кількості
пацієнтів у кожній когорті.<o:p></o:p></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Ref167181240'><sup><span lang=3DUK style=3D'mso-bidi=
-font-size:
12.0pt'>а</span></sup></span><span style=3D'mso-bookmark:_Ref167181240'><sp=
an
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> Інші стани, пов’язані з ПНГ,=
 були
відзначені як «інфаркти нирок і селезінки» і «множинні ураження, пов’язані з
емболічним процесом».</span></span><span lang=3DUK style=3D'mso-bidi-font-s=
ize:
12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Залежно від маси тіла пацієнти
отримували навантажувальну дозу равулізумабу в 1 день, потім підтримувальну
дозу на 15 день і далі кожні 8 тижнів для пацієнтів із масою тіла &#8805;
20&nbsp;кг або один раз кожні 4 тижні для пацієнтів із масою тіла &lt;
20&nbsp;кг. Для пацієнтів, які перебувають на терапії екулізумабом і включе=
ні в
дослідження, планувалося, що 1 день досліджуваної терапії настане через 2 т=
ижні
після введення пацієнту останньої дози екулізумабу.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Режим дозування равулізумабу,=
 який
ґрунтується на масі тіла пацієнта, забезпечував негайне, повне та стійке
інгібування термінальних компонентів системи комплементу протягом 26-тижнев=
ого
періоду первинної оцінки незалежно від попереднього досвіду застосування
екулізумабу. Після початку лікування равулізумабом рівноважні терапевтичні
концентрації равулізумабу в сироватці крові були досягнуті одразу після
введення першої дози та зберігалися протягом 26-тижневого періоду первинної
оцінки в обох когортах. У дослідженні не було випадків проривного гемолізу =
і в
жодного пацієнта після вихідної оцінки концентрація вільного C5 не перевищу=
вала
0,5&nbsp;мкг/мл. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середня відсоткова зміна акти=
вності
ЛДГ порівняно з вихідним значенням становила -47,91&nbsp;% на 183 день у
когорті пацієнтів, які раніше не отримували інгібітори комплементу, та
залишалася стабільною у когорті пацієнтів, які отримували екулізумаб, протя=
гом
26-тижневого періоду первинної оцінки. 60&nbsp;% (3/5) пацієнтів, які раніш=
е не
отримували інгібітори комплементу, і 75&nbsp;% (6/8) пацієнтів, які отримув=
али
екулізумаб, досягли стабілізації рівня гемоглобіну до 26 тижня лікування
відповідно. Можливість уникнути переливання крові була досягнута у 84,6&nbs=
p;%
(11/13) пацієнтів протягом 26-тижневого періоду первинної оцінки.<o:p></o:p=
></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ці проміжні результати ефекти=
вності представлено
в таблиці 11 нижче.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 11 <span style=3D'mso-tab-count:1'> =
  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Результати ефективності в дос=
лідженні
за участю пацієнтів дитячого віку з ПНГ (ALXN1210 PNH-304) — 26-тижневий пе=
ріод
первинної оцінки<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D652
 style=3D'width:488.9pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm 5.65pt 0cm 5.65pt;mso-border-i=
nsideh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:22.7pt'>
  <td width=3D340 style=3D'width:255.0pt;border:solid windowtext 1.0pt;mso-=
border-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Кінцева точка<b><o:p></o:p></b></span=
></p>
  </td>
  <td width=3D161 style=3D'width:120.5pt;border:solid windowtext 1.0pt;bord=
er-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб (раніше не отримували
  лікування, N =3D 5)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D151 style=3D'width:4.0cm;border:solid windowtext 1.0pt;border=
-left:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб (переведені з лікування і=
ншим лікарським
  засобом, N =3D 8)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:23.75pt'>
  <td width=3D340 style=3D'width:255.0pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:23.75pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ — відсоткова зміна пор=
івняно
  з вихідним рівнем<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D161 style=3D'width:120.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:23.75pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>-47,91 (52,716)<o:p></o:p></span></p>
  </td>
  <td width=3D151 style=3D'width:4.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:23.75pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>4,65 (44,702)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:22.7pt'>
  <td width=3D340 style=3D'width:255.0pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Можливість уникнути переливань крові<=
o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Відсотки (95&nbsp;% ДІ)<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D161 style=3D'width:120.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>60,0 (14,66</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 94,73)<o:p></o:p></span></=
p>
  </td>
  <td width=3D151 style=3D'width:4.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>100,0 (63,06</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>100,00)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:22.7pt'>
  <td width=3D340 style=3D'width:255.0pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Стабілізація рівня гемоглобіну<o:p></=
o:p></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Відсотки (95&nbsp;% ДІ)<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D161 style=3D'width:120.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>60,0 (14,66</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 94,73)<o:p></o:p></span></=
p>
  </td>
  <td width=3D151 style=3D'width:4.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:22.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>75 (34,91</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 96,81)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;mso-yfti-lastrow:yes;height:14.15pt'>
  <td width=3D340 style=3D'width:255.0pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>Проривний гемоліз (%)<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D161 style=3D'width:120.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 5.65pt=
 0cm 5.65pt;
  height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>0<o:p></o:p></span></p>
  </td>
  <td width=3D151 style=3D'width:4.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-alt:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:14.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt'><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>0<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'font-size:11.0pt'>ЛДГ — лактатдегідрогеназа<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Довгострокові результати ефек=
тивності
на кінець дослідження при медіанній тривалості лікування 915 днів показали
стійку відповідь на лікування у дітей з ПНГ.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>За даними представлених промі=
жних
результатів ефективність равулізумабу в дітей з ПНГ є схожою з ефективністю,
яка спостерігається в дорослих пацієнтів з ПНГ.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Атиповий гемолітико-уремічний=
 синдром
(аГУС)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування Ультомірісу паці=
єнтам
дитячого віку для лікування аГУС підтверджується даними одного клінічного
дослідження за участю дітей (загалом було включено 31 пацієнта з підтвердже=
ним
аГУС; 28 пацієнтів віком від 10 місяців до 17 років були включені в повну
вибірку для аналізу).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дослідження за участю пацієнт=
ів
дитячого віку (дослідження ALXN1210-aHUS-312)<o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Це педіатричне дослідження бу=
ло 26-тижневим
багатоцентровим дослідженням 3 фази, яке проводили в одній групі пацієнтів
дитячого віку, і пацієнтам було дозволено перейти в додатковий період
тривалістю до 4,5 року.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загалом у дослідження було вк=
лючено 24
пацієнти з підтвердженим аГУС і з підтвердженою ТМА, які раніше не отримува=
ли
лікування екулізумабом, 20 із цих пацієнтів було включено в повну вибірку д=
ля
аналізу. Критерії участі в дослідженні виключали пацієнтів з ТМА через дефі=
цит
ферменту ADAMTS13, із STEC-ГУС і генетичним дефектом метаболізму кобаламіну=
</span><span
lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>&n=
bsp;</span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>С. Чотири пацієнти отримали 1=
 або 2
дози, але потім припинили лікування та були виключені з повної вибірки для
аналізу, оскільки аГУС у них не був підтверджений. Середня вихідна маса тіла
становила 21,2&nbsp;кг, на початок дослідження маса тіла більшості пацієнтів
становила від &#8805;&nbsp;10 до &lt; 20&nbsp;кг. У більшості пацієнтів (70=
,0
%) до лікування були позаниркові ознаки (з боку серцево-судинної системи,
дихальної системи, центральної нервової системи, шлунково-кишкового тракту,
шкіри, скелетних м’язів) або симптоми аГУС. У 35,0 % (n =3D 7) пацієнтів на=
 початок
дослідження спостерігалася ХХН 5 стадії.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загалом у дослідження було вк=
лючено
10 пацієнтів із підтвердженим аГУС і зі встановленими діагнозом ТМА, які бу=
ли
переведені з терапії екулізумабом на терапію равулізумабом. У пацієнтів пов=
инна
була спостерігатися клінічна відповідь на екулізумаб до включення в дослідж=
ення
(тобто ЛДГ &lt; 1,5 &times; ВМН і кількість тромбоцитів &#8805;&nbsp;150000=
/мкл,
а також рШКФ &gt;&nbsp;30&nbsp;мл/хв/1,73 м<sup>2</sup>). Отже, немає
інформації про застосування равулізумабу пацієнтам, рефрактерним до лікуван=
ня
екулізумабом.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 12 представлено вих=
ідні
характеристики пацієнтів дитячого віку, включених у дослідження
ALXN1210-aHUS-312.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 12 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Демографічні та вихідні
характеристики в дослідженні ALXN1210-aHUS-312<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D650
 style=3D'width:487.35pt;margin-left:-5.65pt;border-collapse:collapse;borde=
r:
 none;mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowt=
ext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:27.35pt'>
  <td width=3D254 style=3D'width:190.55pt;border:solid windowtext 1.0pt;mso=
-border-top-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметр<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:solid windowtext 1.0pt;bor=
der-left:
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-top-alt:.25pt;
  mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-right-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ст=
атистичні
  дані<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:solid windowtext 1.0pt;bord=
er-left:
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-top-alt:.25pt;
  mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-right-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб
  (раніше&nbsp;не отримували лікування,<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>N =
=3D 20)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:solid windowtext 1.0pt;borde=
r-left:
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-top-alt:.25pt;
  mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-right-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ра=
вулізумаб
  (переведені&nbsp;з лікування іншим лікарським засобом, <br>
  N =3D 10)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:24.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:24.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вікова категорія на момент =
першого
  інфузійного введення (років)<o:p></o:p></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Від народження до &lt; 2 ро=
ків<o:p></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:24.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:24.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4 =
(20,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:24.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(10,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>від 2 до &lt; 6 років<o:p><=
/o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9 =
(45,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(10,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>від 6 до &lt; 12 років<o:p>=
</o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(25,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(10,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:19.85pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:19.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>від 12 до &lt; 18 років<o:p=
></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2 =
(10,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7 =
(70,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Стать<o:p></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Чоловіча<o:p></o:p></span><=
/p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>8 =
(40,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>9 =
(90,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Раса<sup>a</sup><o:p></o:p>=
</span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Американські індіанці або
  представники корінного населення Аляски<o:p></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(5,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0 =
(0,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Монголоїдна<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(25,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>4 =
(40,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Негроїдна раса чи афроамери=
канці<o:p></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3 =
(15,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(10,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Європеоїдна<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border:none;border-right:solid wi=
ndowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border:none;border-right:solid win=
dowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>11=
 (55,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>5 =
(50,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Невідомо<o:p></o:p></span><=
/p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(5,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0 =
(0,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:8.5pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Трансплантація в анамнезі<o=
:p></o:p></span></p>
  </td>
  <td width=3D141 style=3D'width:105.45pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(5,6)<o:p></o:p></span></p>
  </td>
  <td width=3D132 style=3D'width:99.2pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1 =
(10,0)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:19.85pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:19.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тромбоцити (10<sup>9</sup>/=
л)<o:p></o:p></span></p>
  </td>
  <td width=3D141 valign=3Dtop style=3D'width:105.45pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана </span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>51=
,25 (14</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 125)<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:99.2pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:19.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>28=
1,75&nbsp;</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(2=
07</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 415,5)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гемоглобін (г/л)<o:p></o:p>=
</span></p>
  </td>
  <td width=3D141 valign=3Dbottom style=3D'width:105.45pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><s=
pan
  style=3D'mso-spacerun:yes'> </span>(мін., макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>74=
,25 (32</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 106)<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dbottom style=3D'width:99.2pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>13=
2,0
  (114,5</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 148)<=
o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ (Од/л)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D141 valign=3Dbottom style=3D'width:105.45pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана </span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19=
63,0 </span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(7=
72</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 4985)<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dbottom style=3D'width:99.2pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20=
6,5
  (138,5</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>,</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 356)<=
o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ (мл/хв/1,73&nbsp;м<sup=
>2</sup>)<o:p></o:p></span></p>
  </td>
  <td width=3D141 valign=3Dbottom style=3D'width:105.45pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ме=
діана </span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(м=
ін.,
  макс.)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>22=
,0 (10</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 84)<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dbottom style=3D'width:99.2pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>99=
,75 (54</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 136,5)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D254 valign=3Dtop style=3D'width:190.55pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Необхідність діалізу на вих=
ідному
  рівні<o:p></o:p></span></p>
  </td>
  <td width=3D141 valign=3Dbottom style=3D'width:105.45pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n =
(%)<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>7 =
(35,0)<o:p></o:p></span></p>
  </td>
  <td width=3D132 valign=3Dbottom style=3D'width:99.2pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0 =
(0,0)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ — розрахункова швидкість
клубочкової фільтрації, ЛДГ&nbsp;—&nbsp;лактатдегідрогеназа, макс.&nbsp;—
максимальне значення, мін. — мінімальне значення.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Примітка. Відсоткове співвідн=
ошення
засноване на загальній кількості пацієнтів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3DPatients><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>a<=
/span></sup></a><span
style=3D'mso-bookmark:Patients'></span><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
12.0pt'> Пацієнти могли позначити приналежність до кількох рас.<o:p></o:p><=
/span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Первинною кінцевою точкою бул=
а повна
відповідь ТМА протягом 26-тижневого періоду первинної оцінки, про що свідчи=
ли
нормалізація гематологічних показників (кількість тромбоцитів &#8805;
150&nbsp;&times;&nbsp;10<sup>9</sup>/л та активність ЛДГ &#8804; 246&nbsp;О=
д/л)
і поліпшення рівня креатиніну в сироватці на &#8805; 25&nbsp;% від вихідного
значення у пацієнтів, які раніше не отримували лікування екулізумабом. Паці=
єнти
повинні були відповідати всім критеріям повної відповіді ТМА під час двох
окремих оцінювань, проведених з інтервалом щонайменше 4 тижні (28 днів), та=
 під
час будь-яких проміжних вимірювань.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА спостеріг=
алася у
15 з 20 пацієнтів (75,0&nbsp;%), які раніше не отримували лікування, у ході
26-тижневого періоду первинної оцінки, як показано в таблиці 13.<o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 13 <span style=3D'mso-tab-count:1'> =
  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА і компоне=
нти
повної відповіді ТМА. Аналіз у ході <span style=3D'letter-spacing:.2pt'>26-=
тижневого
періоду первинної оцінки (дослідження ALXN1210-aHUS-312)<o:p></o:p></span><=
/span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D652
 style=3D'width:488.8pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .5pt;
 mso-table-overlap:never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insid=
eh:
 .25pt solid windowtext;mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:11.35pt'>
  <td width=3D315 rowspan=3D2 style=3D'width:236.15pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowte=
xt .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D65 rowspan=3D2 style=3D'width:48.5pt;border:solid windowtext =
1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ус=
ього<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D272 colspan=3D2 style=3D'width:204.15pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;background:white;padding:0cm .5pt 0cm .5pt;height:1=
1.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
цієнти<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:12.25pt'>
  <td width=3D58 style=3D'width:43.2pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-borde=
r-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n<=
b><o:p></o:p></b></span></p>
  </td>
  <td width=3D215 style=3D'width:160.95pt;border:solid windowtext 1.0pt;bor=
der-left:
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;background:white;padding:0cm=
 .5pt 0cm .5pt;
  height:12.25pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ча=
стка
  (95&nbsp;% ДІ)</span><!--[if supportFields]><b><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-begi=
n'></span></span></sup></b><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> REF _Ref167190743 \r \h <s=
pan
  style=3D'mso-spacerun:yes'> </span>\* MERGEFORMAT <b><span style=3D'mso-e=
lement:
  field-separator'></span></b></span></sup><![endif]--><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>a<b><!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F0052=
00650066003100360037003100390030003700340033000000</w:data>
  </xml><![endif]--></b></span></sup><!--[if supportFields]><b><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-end'></span></span></sup></b><![endif]--><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></b></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА<o:p></o=
:p></span></p>
  </td>
  <td width=3D65 valign=3Dbottom style=3D'width:48.5pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20<o:p></o:p></span></p>
  </td>
  <td width=3D58 valign=3Dbottom style=3D'width:43.2pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15<o:p></o:p></span></p>
  </td>
  <td width=3D215 valign=3Dbottom style=3D'width:160.95pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;mso-borde=
r-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,750 (0,509</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,913)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:8.5pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Компоненти повної відповіді=
 ТМА</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
<o:p></o:p></span></p>
  </td>
  <td width=3D65 valign=3Dtop style=3D'width:48.5pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D58 valign=3Dtop style=3D'width:43.2pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D215 valign=3Dtop style=3D'width:160.95pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.35pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm 5.65pt 0cm 10.2pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нормалізація кількості тром=
боцитів<o:p></o:p></span></p>
  </td>
  <td width=3D65 valign=3Dtop style=3D'width:48.5pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20<o:p></o:p></span></p>
  </td>
  <td width=3D58 valign=3Dtop style=3D'width:43.2pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>19<o:p></o:p></span></p>
  </td>
  <td width=3D215 valign=3Dtop style=3D'width:160.95pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,950 (0,751</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,999)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.35pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 10.2pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нормалізація активності ЛДГ=
<o:p></o:p></span></p>
  </td>
  <td width=3D65 valign=3Dtop style=3D'width:48.5pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20<o:p></o:p></span></p>
  </td>
  <td width=3D58 valign=3Dtop style=3D'width:43.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18<o:p></o:p></span></p>
  </td>
  <td width=3D215 valign=3Dtop style=3D'width:160.95pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,900 (0,683</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,988)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:11.35pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 5.65pt 0cm 10.2pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Покращення рівня креатиніну=
 в
  сироватці крові на &#8805;&nbsp;25&nbsp;% від вихідного рівня<o:p></o:p><=
/span></p>
  </td>
  <td width=3D65 valign=3Dtop style=3D'width:48.5pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20<o:p></o:p></span></p>
  </td>
  <td width=3D58 valign=3Dtop style=3D'width:43.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>16<o:p></o:p></span></p>
  </td>
  <td width=3D215 valign=3Dtop style=3D'width:160.95pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,800 (0,563</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,943)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D315 valign=3Dbottom style=3D'width:236.15pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нормалізація гематологічних
  показників<o:p></o:p></span></p>
  </td>
  <td width=3D65 valign=3Dtop style=3D'width:48.5pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20<o:p></o:p></span></p>
  </td>
  <td width=3D58 valign=3Dtop style=3D'width:43.2pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18<o:p></o:p></span></p>
  </td>
  <td width=3D215 valign=3Dtop style=3D'width:160.95pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,900 (0,683</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
,</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,988)<o:p></o:p></span></=
p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ДІ — довірчий інтервал, ЛДГ —
лактатдегідрогеназа, ТМА — тромботична мікроангіопатія.<o:p></o:p></span></=
p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167190743"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>а</span></sup></a><span
style=3D'mso-bookmark:_Ref167190743'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> 95&nbsp;% ДІ для цієї частки пацієнтів базувалися на методі
асимптотичної гаусівської апроксимації з поправкою на безперервність.</span=
></span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У ході первинної оцінки медіа=
на часу
досягнення повної відповіді ТМА становила 30 днів (від 15 до 99 днів) Усі
пацієнти з повною відповіддю ТМА зберегли її протягом усього періоду первин=
ної
оцінки з постійною позитивною динамікою функції нирок. Збільшення середньої
кількості тромбоцитів спостерігалося невдовзі після початку застосування
равулізумабу з підвищенням із 71,70&nbsp;&times;&nbsp;10<sup>9</sup>/л на
вихідному рівні до 302,41&nbsp;&times;&nbsp;10<sup>9</sup>/л на 8 день та
зберігалось вище 304&nbsp;&times;&nbsp;10<sup>9</sup>/л при всіх наступних =
візитах
після дня 22 <span style=3D'mso-spacerun:yes'> </span>у період первинної оц=
інки
(26 тижнів).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повна відповідь ТМА спостеріг=
алася ще
в трьох пацієнтів протягом додаткового періоду (на 295 день у 2 пацієнтів т=
а на
351 день в 1 пацієнта), що зумовило досягнення повної відповіді ТМА у 18 з =
20
пацієнтів дитячого віку (90&nbsp;%; 95&nbsp;% ДІ: 68,3&nbsp;%, 98,8&nbsp;%)=
 до
кінця дослідження. <span style=3D'mso-spacerun:yes'> </span><o:p></o:p></sp=
an></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість пацієнтів, у яких
спостерігалася відповідь за окремими компонентами, збільшилася: до 19 із 20=
 (95,0&nbsp;%;
95 % ДІ: 75,1&nbsp;%; 99,9&nbsp;%) осіб – за нормалізацією кількості
тромбоцитів, до 19 із 20 (95,0&nbsp;%; 95 % ДІ: 75,1&nbsp;%; 99,9&nbsp;%) о=
сіб –
за нормалізацією активності ЛДГ і до 18 із 20 (90,0&nbsp;%; 95 % ДІ: 68,3 %=
; 98,9&nbsp;%)
осіб – за поліпшенням функції нирок.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Усі 7 пацієнтів, яким був пот=
рібен
діаліз під час включення в дослідження, змогли припинити діаліз; 6 із них
зробили це вже до 36-го дня. Під час лікування жодному пацієнту не було
розпочато або відновлено діаліз. З 16 пацієнтів з доступними вихідними дани=
ми
та даними станом на тиждень 52 (день 351) у 16 пацієнтів спостерігалося пос=
лаблення
стадії хронічної хвороби нирок (ХХН) порівняно з вихідним рівнем. У пацієнт=
ів з
доступними даними станом на кінець дослідження продовжували спостерігатися
покращення або відсутність змін щодо стадії ХХН. Покращення функції нирок,
виміряне за допомогою рШКФ, залишалося стабільним до кінця дослідження. У т=
аблиці
14 узагальнено результати оцінки ефективності в дослідженні ALXN1210-aHUS-3=
12
за вторинними кінцевими точками.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 14 <span style=3D'mso-tab-count:1'> =
  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Результати вторинних кінцевих=
 точок
ефективності за 26-тижневий період первинної оцінки в дослідженні
ALXN1210-aHUS-312 <o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D661
 style=3D'width:495.9pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .5pt;
 mso-border-top-alt:solid windowtext .25pt;mso-table-overlap:never;mso-padd=
ing-alt:
 0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid windowtext;mso-border-ins=
idev:
 .25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:22.7pt'>
  <td width=3D378 style=3D'width:283.25pt;border:solid windowtext 1.0pt;mso=
-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Па=
раметри<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D284 colspan=3D2 style=3D'width:212.65pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>До=
слідження
  ALXN1210-aHUS-312<b><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(N=
&nbsp;=3D&nbsp;20)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:8.5pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гематологічні показники при=
 ТМА,
  183 день<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Сп=
остережуване
  значення (n =3D 17)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
іна від
  вихідного рівня (n =3D 17)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:8.5pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тромбоцити (10<sup>9</sup>/=
л)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:8.5pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
4,94
  (75,711)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
5,59
  (91,827)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:8.5pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>31=
8,00<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
7,00<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:8.5pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Активність ЛДГ (Од/л) у сир=
оватці
  крові<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:8.5pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border:none;border-r=
ight:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>26=
2,41
  (59,995)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-2=
044,13
  (1328,059)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:8.5pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.35pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
7,00<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>-1=
851,50<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:34.0pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Підвищення рівня гемоглобін=
у на &#8805;&nbsp;20&nbsp;г/л
  від вихідного рівня з підтверджувальним результатом під час періоду перви=
нної
  оцінки<o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dtop style=3D'width:212.65pt;border:n=
one;
  border-right:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .=
25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-top-alt:solid windo=
wtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:34.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;height:8.5pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>n/m<o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dtop style=3D'width:212.65pt;border:n=
one;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>17=
/20<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:10;height:8.5pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Частка (95&nbsp;% ДІ)</span=
><!--[if supportFields]><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF bookmark001 \h <span style=3D'mso-spacerun:yes'> </span>\* MERGEFORMA=
T <span
  style=3D'mso-element:field-separator'></span></span><![endif]--><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>*<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000C00000062006F=
006F006B006D00610072006B003000300031000000</w:data>
  </xml><![endif]--></span><!--[if supportFields]><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dbottom style=3D'width:212.65pt;borde=
r-top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
850 (0,621</span><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
;</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,968)<o:p></o:p></span></=
p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:11;height:8.5pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:8.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зміна від вихідного рівня с=
тадії
  ХХН, 183 день <o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 rowspan=3D2 valign=3Dtop style=3D'width:212.6=
5pt;
  border:none;border-right:solid windowtext 1.0pt;mso-border-top-alt:solid =
windowtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-top-alt:solid windo=
wtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:12;height:11.85pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:11.85pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Позитивна динаміка</span><!=
--[if supportFields]><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF bookmark002 \h <span style=3D'mso-spacerun:yes'> </span>\* MERGEFORMA=
T <span
  style=3D'mso-element:field-separator'></span></span></sup><![endif]--><su=
p><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>a<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000C00000062006F=
006F006B006D00610072006B003000300032000000</w:data>
  </xml><![endif]--></span></sup><!--[if supportFields]><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></sup><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:13;height:12.05pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border-top:none;bord=
er-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:12.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
n</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>/</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>m<o:p></o:p><=
/span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dtop style=3D'width:212.65pt;border:n=
one;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15=
/17<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:14;height:12.05pt'>
  <td width=3D378 valign=3Dtop style=3D'width:283.25pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:12.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Частка (95&nbsp;% ДІ)</span=
><!--[if supportFields]><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF bookmark001 \h <span style=3D'mso-spacerun:yes'> </span>\* MERGEFORMA=
T <span
  style=3D'mso-element:field-separator'></span></span><![endif]--><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>*<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000C00000062006F=
006F006B006D00610072006B003000300031000000</w:data>
  </xml><![endif]--></span><!--[if supportFields]><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dtop style=3D'width:212.65pt;border-t=
op:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
882
  (0,636</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,985=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:15;height:12.05pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:12.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Погіршення<sup>б</sup><o:p>=
</o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dtop style=3D'width:212.65pt;border:n=
one;
  border-right:solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .=
25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-top-alt:solid windo=
wtext .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o=
:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:16;height:12.05pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:12.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>=
n</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>/</span><span lang=3DEN-US
  style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>m</span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dbottom style=3D'width:212.65pt;borde=
r:none;
  border-right:solid windowtext 1.0pt;mso-border-left-alt:solid windowtext =
.25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0/=
11<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:17;height:12.05pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border:solid wind=
owtext 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .25pt;mso-border-bot=
tom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 22.1pt;height:12.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Частка (95&nbsp;% ДІ)</span=
><!--[if supportFields]><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  REF bookmark001 \h <span style=3D'mso-spacerun:yes'> </span>\* MERGEFORMA=
T <span
  style=3D'mso-element:field-separator'></span></span><![endif]--><span lan=
g=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>*<!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000C00000062006F=
006F006B006D00610072006B003000300031000000</w:data>
  </xml><![endif]--></span><!--[if supportFields]><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D284 colspan=3D2 valign=3Dbottom style=3D'width:212.65pt;borde=
r-top:none;
  border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid =
windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>0,=
000
  (0,000</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.0pt;mso-an=
si-language:
  EN-US'>;</span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> 0,285=
)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:18;height:11.35pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>рШКФ (мл/хв/1,73 м<sup>2</s=
up>),
  183 день<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Аб=
солютне
  значення <o:p></o:p></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(n=
 =3D 17)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зм=
іна від
  вихідного рівня (n =3D 17)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:19;height:11.35pt'>
  <td width=3D378 valign=3Dbottom style=3D'width:283.25pt;border-top:none;b=
order-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-right-alt:solid win=
dowtext .25pt;
  background:white;padding:0cm 5.65pt 0cm 15.6pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border:none;borde=
r-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
8,5
  (56,87) <o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>85=
,4
  (54,33)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:20;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D378 style=3D'width:283.25pt;border:solid windowtext 1.0pt;bor=
der-top:
  none;mso-border-left-alt:solid windowtext .25pt;mso-border-bottom-alt:sol=
id windowtext .5pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
5.65pt 0cm 15.6pt;
  height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Медіана<o:p></o:p></span></=
p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.35pt;border-top:none;b=
order-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10=
8,0<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>80=
,0<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk171502774"><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>=
рШКФ —
розрахункова швидкість клубочкової фільтрації, ЛДГ — лактатдегідрогеназа, Т=
МА&nbsp;—
тромботична мікроангіопатія, n — кількість </span></a><a name=3D"_Hlk171502=
791"><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>пацієнтів із доступними даними для конкретної оцінки, які здійснили
візит на день 183, m — кількість пацієнтів, які відповідають певному критер=
ію.
Стадія ХХН класифікується на підставі стадій ХХН, визначених Національним ф=
ондом
нирок США. 1 стадія розглядається як найкраща категорія, тоді як 5 стадія
розглядається як найгірша категорія. Початковий рівень отримано на підставі
останнього доступного значення рШКФ перед початком лікування. Позитивна
динаміка/Погіршення: Порівняно зі стадією ХХН на вихідному рівні.<o:p></o:p=
></span></span></a></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3Dbookmark001><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'=
>*</span></sup></a></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&nbsp;</span></sup></span></s=
pan><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>95&nbsp;% ДІ ґрунтуються на т=
очних
довірчих межах з використанням методу Клоппера – Пірсона.<o:p></o:p></span>=
</span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3Dbookmark002><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'=
>a</span></sup></a></span></span><span
style=3D'mso-bookmark:bookmark002'></span><span style=3D'mso-bookmark:_Hlk1=
71502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> За винятком пацієнтів з 1 стадією ХХН на вихідному рівні, оскільки=
 в
них не може бути позитивної динаміки. <o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>б </span></sup></span></span>=
<span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>За винятком пацієнтів із 5 ст=
адією
ХХН на вихідному рівні, оскільки в них не може бути погіршення.<o:p></o:p><=
/span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У переведених на равулізумаб =
пацієнтів,
які раніше отримували лікування екулізумабом, зберігався контроль за
захворюванням, про що свідчили стабільні гематологічні показники та показни=
ки
функції нирок, без помітного впливу на безпеку.<o:p></o:p></span></span></s=
pan></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Відзначено схожу ефективність
равулізумабу в лікуванні аГУС у пацієнтів дитячого віку та дорослих пацієнт=
ів.
Кінцевий аналіз ефективності дослідження для всіх пацієнтів дитячого віку, =
у яких
медіанна тривалість лікування равулізумабом становила 130,60 тижня, підтвер=
див,
що відповіді на лікування равулізумабом, які спостерігалися під час періоду
первинної оцінки, зберігалися протягом усього періоду дослідження.<o:p></o:=
p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Генералізована міастенія грав=
іс (гМГ)<o:p></o:p></span></i></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Європейське агентство з контр=
олю
лікарських засобів відтермінувало зобов’язання надати результати досліджень
застосування лікарського засобу Ультоміріс в одній або декількох підгрупах
пацієнтів дитячого віку, які отримують лікування з приводу міастенії. Див.
інформацію щодо застосування дітям в розділі «Спосіб застосування та дози».=
<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Оптиконевромієліт з розладом =
спектру
(ОНМРС)<o:p></o:p></span></i></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Європейське агентство з контр=
олю
лікарських засобів відтермінувало зобов’язання надати результати досліджень=
 застосування
лікарського засобу Ультоміріс в одній або декількох підгрупах пацієнтів
дитячого віку, які отримують лікування з приводу ОНМРС. Див. інформацію щодо
застосування дітям в розділі «Спосіб застосування та дози».<o:p></o:p></spa=
n></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3Dbookmark34></a><a name=3Dbookmark33><span style=3D'mso-bookmark:book=
mark34'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold;mso-=
bidi-font-style:
italic'><o:p>&nbsp;</o:p></span></span></a></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
style=3D'mso-bookmark:bookmark33'><span style=3D'mso-bookmark:bookmark34'><=
span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold;mso-=
bidi-font-style:
italic'>Фармакокінетика</span></span></span></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-style:italic'><o=
:p></o:p></span></b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Всмоктування<o:p></o:p></span=
></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Оскільки равулізумаб вводитьс=
я шляхом
внутрішньовенної інфузії, а лікарською формою є розчин, вважається, що
біодоступність равулізумабу після внутрішньовенного введення становить 100 =
%.
Час досягнення максимальної спостережуваної концентрації (t<sub>max</sub>)
очікується до кінця інфузійного введення або незабаром після нього. Рівнова=
жні
терапевтичні концентрації лікарського засобу досягаються після введення пер=
шої
дози.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Розподіл<o:p></o:p></span></u=
></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Розрахунковий середній (станд=
артне
відхилення (СВ)) центральний об’єм і об’єм розподілу в рівноважному стані в
дорослих пацієнтів і дітей із ПНГ чи аГУС та дорослих пацієнтів із гМГ чи О=
НМРС
подано в таблиці 15.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Біотрансформація та виведення=
<o:p></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Очікується, що равулізумаб як
моноклональне антитіло імуноглобуліну гамма (IgG) буде метаболізуватися у т=
акий
самий спосіб, як і інші ендогенні IgG (розщеплення на малі пептиди та
амінокислоти катаболічним шляхом) та підлягати виведенню аналогічним способ=
ом.
Равулізумаб містить амінокислоти тільки природного походження та не має від=
омих
активних метаболітів. Середній (СВ) термінальний період напіввиведення та
кліренс равулізумабу в дорослих пацієнтів і дітей із ПНГ, у дорослих пацієн=
тів
і дітей з аГУС, а також у дорослих пацієнтів із гМ чи ОНМРС наведені в табл=
иці
15.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span style=3D'mso-bookmark:_Hlk171502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'>Таблиця&nbsp;15 =
<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Розрахунковий середній об’єм,=
 параметри
розподілу, біотрансформації та виведення при застосуванні равулізумабу</spa=
n></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p></o:p></span></span></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D661
 style=3D'width:495.9pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .5pt;
 mso-border-top-alt:solid windowtext .25pt;mso-table-overlap:never;mso-padd=
ing-alt:
 0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid windowtext;mso-border-ins=
idev:
 .25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:45.6pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .25pt;mso-border-left-alt:solid windowtex=
t .5pt;
  background:white;padding:0cm 2.85pt 0cm 2.85pt;height:45.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Показник<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:45.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі пацієнти&nbsp;та діти з ПНГ<b><o:p></o:p></b></span></spa=
n></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 5.65pt 0cm 5.65pt;
  height:45.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі пацієнти та діти з аГУС<b><o:p></o:p></b></span></span></=
span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 2.85pt 0cm 2.85pt;
  height:45.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі пацієнти&nbsp;з гМГ<b><o:p></o:p></b></span></span></span=
></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm 2.85pt 0cm 2.85pt;height:45.6pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі пацієнти&nbsp;з ОНМРС<b><o:p></o:p></b></span></span></sp=
an></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:13.05pt'>
  <td width=3D274 rowspan=3D2 style=3D'width:205.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm 2.85pt 0cm 5.65pt;height:13.05pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Розрахунковий середній цент=
ральний
  об’єм (л) <o:p></o:p></span></span></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 style=3D'width:3.0cm;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі:&nbsp;3,44 (0,66)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 style=3D'width:70.9pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Дорослі:&nbsp;3,25 (0,61)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 style=3D'width:70.85pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>3,42 (0,756)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 style=3D'width:63.8pt;border:none;border-right:solid windo=
wtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>2,91 (0,571)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:13.05pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 style=3D'width:3.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Діти: 2,87<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 style=3D'width:70.9pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Діти: 1,14<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 style=3D'width:70.85pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 style=3D'width:63.8pt;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-lef=
t-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-bottom-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:13.05pt'><span style=3D'mso-bookma=
rk:
  _Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:19.9pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm 2.85pt 0cm 5.65pt;height:19.9pt'><span style=3D'mso-boo=
kmark:
  _Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:19.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>(0,60)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dbottom style=3D'width:70.9pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:19.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>(0,51)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:19.9pt'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;mso-border-right-alt:solid windowte=
xt .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:19.9pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:26.9pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 2.85pt 0cm 5.65pt;height:26.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Об’єм розподілу в рівноважн=
ому
  стані (літри)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:26.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>5,30 (0,9)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:26.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>5,22 (1,85)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:26.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>5,74 (1,16)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:26.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>4,77 (0,819)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.9pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 2.85pt 0cm 5.65pt;height:11.9pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></span></span></p>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:27.35pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 2.85pt 0cm 5.65pt;height:27.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кінцевий період напіввиведе=
ння
  (доба)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>49,6 (9,1)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>51,8 (16,2)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>56,6 (8,36)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:27.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>64,3 (11,0)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:12.25pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .25pt;
  background:white;padding:0cm 2.85pt 0cm 5.65pt;height:12.25pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:12.25pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:14.75pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border-top:none;borde=
r-left:
  solid windowtext 1.0pt;border-bottom:none;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-top-alt:solid window=
text .25pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-right-alt:solid wind=
owtext .25pt;
  background:white;padding:0cm 2.85pt 0cm 5.65pt;height:14.75pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кліренс (літри/добу)<o:p></=
o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:14.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>0,08 (0,022)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:14.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>0,08 (0,04)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .25pt;background:white;padding:0cm =
.5pt 0cm .5pt;
  height:14.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>0,08 (0,02)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border:none;border-righ=
t:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:14.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>0,05 (0,016)<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:9;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D274 valign=3Dtop style=3D'width:205.3pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-bott=
om-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .25pt;backgro=
und:
  white;padding:0cm 2.85pt 0cm 5.65pt;height:11.35pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Середнє значення (СВ)<o:p><=
/o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D95 valign=3Dtop style=3D'width:70.9pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D94 valign=3Dtop style=3D'width:70.85pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D85 valign=3Dtop style=3D'width:63.8pt;border-top:none;border-=
left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .5pt;mso-border-right-alt:solid wi=
ndowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'></span></span>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></s=
pan></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>аГУС — атиповий гемолітико-ур=
емічний
синдром, гМГ – генералізована міастенія гравіс, ОНМРС&nbsp;—&nbsp;оптиконев=
ромієліт
з розладом спектру, ПНГ&nbsp;—&nbsp;пароксизмальна нічна гемоглобінурія, СВ=
 —
стандартне відхилення.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лінійність/нелінійність<o:p><=
/o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У досліджуваному діапазоні до=
з та
режимів застосування равулізумаб продемонстрував пропорційну дозі та лінійн=
у за
часом фармакокінетику (ФК).<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Особливі групи пацієнтів<o:p>=
</o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Маса тіла<o:p></o:p></span></=
i></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Маса тіла є клінічно значущою
коваріатою для пацієнтів з ПНГ та аГУС, гМГ чи ОНМРС, яка призводить до
зниження експозиції в пацієнтів з більшою масою тіла. Режим дозування,
розрахований з огляду на масу тіла, наведено в розділі «Спосіб застосування=
 та
дози», таблицях 18, 20 і 21.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Формальні дослідження впливу =
статі,
раси, віку (літній вік) пацієнта, порушення функції печінки та нирок на
фармакокінетику равулізумабу не проводилися. Проте на підставі оцінки попул=
яційної
фармакокінетики не виявлено впливу статі, віку, раси та функції печінки або
нирок на параметри ФК равулізумабу у здорових добровольців, які брали участ=
ь у
дослідженнях, а також у пацієнтів із ПНГ, аГУС, гМГ та ОНМРС. Отже, коригув=
ання
дози не потрібне.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Фармакокінетику равулізумабу
досліджували у пацієнтів з аГУС з різним ступенем ниркової недостатності,
включно з пацієнтами, які отримували діаліз. Відмінностей фармакокінетичних
параметрів у цих підгрупах пацієнтів, включаючи пацієнтів із протеїнурією, =
не
відзначено.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p>&nbsp;</o:p></span></b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Клінічні характеристики<o:p></o:p></span></b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Показання<o:p></o:p></span></=
i></b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пароксизмальна нічна гемоглоб=
інурія
(ПНГ)<o:p></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс п=
оказаний
для лікування дорослих та дітей з масою тіла не менше 10 кг з ПНГ, а саме:<=
o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpFirst style=3D'margin-top:0cm;margin-right:0=
cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l12 level1 lfo21'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>пацієнтів
із гемолізом із клінічними симптомами, які свідчать про високу активність
захворювання;<o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l12 level1 lfo21'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>пацієнтів,
у яких спостерігається клінічно стабільний стан після лікування екулізумабом
протягом щонайменше 6 попередніх місяців.<o:p></o:p></span></span></span></=
p>

<p class=3DMsoListParagraphCxSpLast style=3D'margin-top:0cm;margin-right:0c=
m;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify'><span style=3D'mso-bookmark:_Hlk171502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Атиповий гемолітико-уремічний=
 синдром
(аГУС)<o:p></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс п=
оказаний
для лікування дорослих та дітей з масою тіла не менше 10 кг з аГУС, які ран=
іше
не отримували інгібітори комплементу або отримували екулізумаб протягом
щонайменше 3 місяців і мають підтверджену відповідь на лікування екулізумаб=
ом.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Генералізована міастенія грав=
іс (гМГ)<o:p></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс п=
оказаний
як доповнення до стандартної терапії дорослим пацієнтам з гМГ, у яких виявл=
ено
антитіла до ацетилхолінових рецепторів (АхР).<o:p></o:p></span></span></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Оптиконевромієліт з розладом =
спектру
(ОНМРС)<o:p></o:p></span></u></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс п=
оказаний
для лікування дорослих пацієнтів з ОНМРС, у яких виявлено антитіла до
аквапорину 4 (AQP4), див. розділ «Фармакологічні властивості».<o:p></o:p></=
span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Протипоказання<span style=3D'=
mso-bidi-font-weight:
bold;mso-bidi-font-style:italic'><o:p></o:p></span></span></i></b></span></=
span></p>

<p class=3DMsoListParagraphCxSpFirst style=3D'margin-top:0cm;margin-right:0=
cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l17 level1 lfo24'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>Підвищена
чутливість до діючої речовини або будь-якої з допоміжних речовин, зазначени=
х у
розділі&nbsp; «Склад».<o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l17 level1 lfo24'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>Наявність
у пацієнта інфекції, спричиненої <i>Neisseria meningitidis</i>, яку не
вилікували на момент початку лікування, див. розділ «Особливості застосуван=
ня».<o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpLast style=3D'margin-top:0cm;margin-right:0c=
m;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l17 level1 lfo24'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:Symbol;mso-fareast=
-font-family:
Symbol;mso-bidi-font-family:Symbol'><span style=3D'mso-list:Ignore'>·<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>Відсутність
у пацієнта вакцинації проти інфекції <i>Neisseria meningitidis</i>, окрім в=
ипадків,
коли пацієнт отримує профілактичне лікування відповідними антибіотиками
протягом 2 тижнів після вакцинації, див. розділ «Особливості застосування».=
<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;background:white'><o:p>&nbsp;<=
/o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3D"_Hlk207725719"><b><i><span lang=3DUK style=3D'mso-bidi-font-size:12=
.0pt;
background:white'>Особливі заходи безпеки</span></i></b></a></span></span><=
span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
style=3D'mso-bookmark:_Hlk207725719'><b><i><span lang=3DUK style=3D'mso-bid=
i-font-size:
12.0pt'><o:p></o:p></span></i></b></span></span></span></p>

<span style=3D'mso-bookmark:_Hlk207725719'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кожен флакон призначений тіль=
ки для
одноразового використання.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Необхідно розводити концентра=
т для
розчину для інфузій до отримання кінцевої концентрації розчину для інфузій
50&nbsp;мг/мл.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Слід дотримуватися асептичних=
 умов.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Приготування лікарського засо=
бу Ультоміріс,
концентрату для розчину для інфузій, проводиться таким чином: <o:p></o:p></=
span></span></span></p>

<p class=3DMsoListParagraphCxSpFirst style=3D'margin-top:0cm;margin-right:0=
cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>1.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кількість флаконів для розвед=
ення
визначають на підставі маси тіла пацієнта та призначеної дози, див. розділ
«Спосіб застосування та дози».<o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>2.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>До розведення розчин у флакон=
і слід
оцінити візуально; розчин не повинен містити видимі часточки чи осад. Не
використовуйте лікарський засіб при виявленні видимих часточок або осаду.<o=
:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>3.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Розрахований об’єм лікарськог=
о засобу
набирають із відповідної кількості флаконів і розводять у пакеті для інфузі=
ї з
використанням розчину натрію хлориду 9&nbsp;мг/мл (0,9&nbsp;%) для ін’єкцій.
Див. довідкові таблиці щодо застосування лікарського засобу далі. Лікарський
засіб слід змішувати обережно. Не струшувати.<o:p></o:p></span></span></spa=
n></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>4.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Після розведення кінцева конц=
ентрація
розчину для інфузії становить 50&nbsp;мг/мл.<o:p></o:p></span></span></span=
></p>

<p class=3DMsoListParagraphCxSpMiddle style=3D'margin-top:0cm;margin-right:=
0cm;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>5.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Приготований розчин слід ввод=
ити
негайно після приготування або зберігати за температури 2–8&nbsp;°C. При
зберіганні приготованого розчину за температури 2–8&nbsp;°C перед введенням
його необхідно нагріти до кімнатної температури. Лікарський засіб не можна
вводити внутрішньовенно струминно чи болюсно. Мінімальна тривалість інфузії=
 вказана
в таблицях 22 і 23. Інфузію необхідно виконувати через фільтр з розміром пор
0,2&nbsp;мкм. Після введення лікарського засобу Ультоміріс необхідно промити
систему для внутрішньовенного введення розчином натрію хлориду 0,9&nbsp;% д=
ля
ін’єкцій.<o:p></o:p></span></span></span></p>

<p class=3DMsoListParagraphCxSpLast style=3D'margin-top:0cm;margin-right:0c=
m;
margin-bottom:0cm;margin-left:17.85pt;margin-bottom:.0001pt;mso-add-space:a=
uto;
text-align:justify;text-indent:-17.85pt;mso-list:l19 level1 lfo22'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><![if !supportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>6.<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </spa=
n></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Якщо лікарський засіб не
використовується одразу після розведення, час зберігання за температури
2–8&nbsp;°C не повинен перевищувати 24 годин або 4 годин за кімнатної
температури з урахуванням передбачуваної тривалості інфузійного введення.<o=
:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></span></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span style=3D'mso-bookmark:_Hlk171502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'>Таблиця 16 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Довідкова </span></span></span><span style=3D'mso-bookmark:_Hlk17150=
2791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-bidi-font-weight:bold'>таблиця щодо введення навантажувальної до=
зи лікарського
засобу Ультоміріс</span></span></span><span style=3D'mso-bookmark:_Hlk17150=
2791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'><o:p></o:p></spa=
n></span></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'margin-left:5.65pt;border-collapse:collapse;border:none;mso-borde=
r-alt:
 solid windowtext .25pt;mso-table-overlap:never;mso-padding-alt:0cm .5pt 0c=
m .5pt;
 mso-border-insideh:.25pt solid windowtext;mso-border-insidev:.25pt solid w=
indowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:38.0pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Діапазон маси тіла (кг)<b style=3D'mso-bidi-font-weight:normal'><=
sup>а</sup>
  <o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Навантажува-льна доза (мг)<b style=3D'mso-bidi-font-weight:normal=
'><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм&nbsp;ЛЗ Ультоміріс (мл)<b style=3D'mso-bidi-font-weight:nor=
mal'><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм розчину <br>
  NaCl (мл) для розведення<b style=3D'mso-bidi-font-weight:normal'><sup>б</=
sup><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Загальний об’єм (мл)<b style=3D'mso-bidi-font-weight:normal'><o:p=
></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:13.05pt'>
  <td width=3D110 style=3D'width:82.3pt;border:solid windowtext 1.0pt;borde=
r-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>1=
0 до
  &lt; 20<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dbottom style=3D'width:80.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.3pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.55pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:88.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>2=
0 до
  &lt; 30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>900<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>9<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>9<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:88.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>18<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:13.05pt'>
  <td width=3D110 style=3D'width:82.3pt;border:solid windowtext 1.0pt;borde=
r-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>3=
0 до
  &lt; 40<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dbottom style=3D'width:80.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>1200<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.3pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.55pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 style=3D'width:88.1pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>24<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>4=
0 до
  &lt; 60<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>2400<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>24<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>24<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>48<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>6=
0 до
  &lt; 100<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>2700<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>27<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>27<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>54<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:6;mso-yfti-lastrow:yes;height:13.05pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>1=
00<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 style=3D'width:80.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>3000<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 style=3D'width:94.3pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 style=3D'width:94.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:88.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>60<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3D"_Ref167193682"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
mso-bidi-font-weight:bold'>а </span></sup></a></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
style=3D'mso-bookmark:_Ref167193682'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-bidi-font-weight:bold'>Маса тіла на момент лікування.</span></sp=
an></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'><o:=
p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><a
name=3D"_Ref167193688"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt;
mso-bidi-font-weight:bold'>б</span></sup></a></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
style=3D'mso-bookmark:_Ref167193688'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-bidi-font-weight:bold'> Лікарський засіб Ультоміріс слід розводи=
ти
тільки розчином натрію хлориду 9&nbsp;мг/мл (0,9&nbsp;%) для ін’єкцій.</spa=
n></span></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'><o:=
p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span style=3D'mso-bookmark:_Hlk171502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'>Таблиця 17 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Довідкова </span></span></span><span style=3D'mso-bookmark:_Hlk17150=
2791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-bidi-font-weight:bold'>таблиця щодо введення підтримувальної дози
лікарського засобу Ультоміріс</span></span></span><span style=3D'mso-bookma=
rk:
_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso-bidi-lang=
uage:
EN-US'><o:p></o:p></span></span></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'margin-left:5.65pt;border-collapse:collapse;border:none;mso-borde=
r-alt:
 solid windowtext .25pt;mso-table-overlap:never;mso-padding-alt:0cm .5pt 0c=
m .5pt;
 mso-border-insideh:.25pt solid windowtext;mso-border-insidev:.25pt solid w=
indowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:38.0pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Діапазон маси тіла (кг)<sup>а</sup><b style=3D'mso-bidi-font-weig=
ht:
  normal'><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Підтримуваль-на доза (мг)<b style=3D'mso-bidi-font-weight:normal'=
><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм&nbsp;ЛЗ Ультоміріс (мл)<b style=3D'mso-bidi-font-weight:nor=
mal'><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм розчину <br>
  NaCl (мл) для розведення<b style=3D'mso-bidi-font-weight:normal'><sup>б</=
sup><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Загальний об’єм (мл)<b style=3D'mso-bidi-font-weight:normal'><o:p=
></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:13.05pt'>
  <td width=3D110 style=3D'width:82.3pt;border:solid windowtext 1.0pt;borde=
r-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>1=
0 до
  &lt; 20<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dbottom style=3D'width:80.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.3pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.55pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>2=
0 до
  &lt; 30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>2100<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>21<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>21<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>42<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:13.05pt'>
  <td width=3D110 style=3D'width:82.3pt;border:solid windowtext 1.0pt;borde=
r-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>3=
0 до
  &lt; 40<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dbottom style=3D'width:80.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>2700<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.3pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>27<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dbottom style=3D'width:94.55pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>27<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>54<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>4=
0 до
  &lt; 60<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>3000<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>60<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:13.05pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>6=
0 до
  &lt; 100<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 valign=3Dtop style=3D'width:80.15pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>3300<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.3pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>33<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 valign=3Dtop style=3D'width:94.55pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>33<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>66<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:6;mso-yfti-lastrow:yes;height:13.05pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif;
  mso-bidi-font-weight:bold'>&#8805; </span></span></span></span><span
  style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk1715=
02774'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>1=
00<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D107 style=3D'width:80.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>3600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 style=3D'width:94.3pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>36<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D126 style=3D'width:94.55pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt;mso-bidi-font-weight:bold'>36<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:88.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:13.05pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>72<span style=3D'mso-bidi-font-weight:bold'><o:p></o:p></span></s=
pan></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>а</=
span></sup></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'> Ма=
са тіла
на момент лікування.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>б</=
span></sup></span></span><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'> Лі=
карський
засіб Ультоміріс слід розводити тільки розчином натрію хлориду 9&nbsp;мг/мл
(0,9&nbsp;%) для ін’єкцій.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span style=3D'mso-bookmark:_Hlk171502791'><span
style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-fareast-language:EN-US;mso-bidi-language:EN-US'>Таблиця 18 <o:p>=
</o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Довідкова таблиця щодо введен=
ня
додаткової дози лікарського засобу Ультоміріс<span style=3D'mso-bidi-font-w=
eight:
bold'><o:p></o:p></span></span></span></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'margin-left:5.65pt;border-collapse:collapse;border:none;mso-borde=
r-alt:
 solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;mso-table-=
overlap:
 never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid win=
dowtext;
 mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:22.7pt'>
  <td width=3D103 valign=3Dtop style=3D'width:77.3pt;border:solid windowtex=
t 1.0pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm 2.85pt 0cm 2.85pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Діапазон маси тіла (кг)<sup>а</sup><b><o:p></o:p></b></span></spa=
n></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dtop style=3D'width:81.85pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 2.85pt 0cm 2.85pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Додаткова доза (мг)<b><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dtop style=3D'width:87.1pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 2.85pt 0cm 2.85pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм ЛЗ&nbsp;Ультоміріс (мл)<b><o:p></o:p></b></span></span></sp=
an></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dtop style=3D'width:92.4pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 2.85pt 0cm 2.85pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Об’єм розчину NaCl (мл) для розведення<sup>б</sup><b><o:p></o:p><=
/b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:87.6pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:22.7pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>Загальний об’єм (мл)<b><o:p></o:p></b></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.35pt'>
  <td width=3D103 rowspan=3D3 valign=3Dtop style=3D'width:77.3pt;border:sol=
id windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif'>&=
#8805;
  </span></span></span></span><span style=3D'mso-bookmark:_Hlk171502791'><s=
pan
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>40 до &lt; 60<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;mso-borde=
r-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;mso-borde=
r-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:87.6pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .25pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;mso-borde=
r-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border:none;border=
-right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-left-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1200<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .5pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border:none;border-=
right:
  solid windowtext 1.0pt;mso-border-left-alt:solid windowtext .5pt;mso-bord=
er-left-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 style=3D'width:87.6pt;border:none;border-right:solid wind=
owtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>24<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.35pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .25pt;mso-border-left-alt:solid wind=
owtext .25pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1500<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:87.6pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.35pt'>
  <td width=3D103 rowspan=3D3 valign=3Dtop style=3D'width:77.3pt;border:sol=
id windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif'>&=
#8805;
  </span></span></span></span><span style=3D'mso-bookmark:_Hlk171502791'><s=
pan
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>60 до &lt; 100<o:p></o:p></span></span></span></p>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'><o:p>&nbsp;</o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dtop style=3D'width:81.85pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dtop style=3D'width:87.1pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dtop style=3D'width:92.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:87.6pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.35pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dtop style=3D'width:81.85pt;border:none;border-ri=
ght:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1500<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dtop style=3D'width:87.1pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dtop style=3D'width:92.4pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:87.6pt;border:none;border-rig=
ht:solid windowtext 1.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-right-alt:solid windowtext .5pt;background:white;padding:0cm .=
5pt 0cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:20.85pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dtop style=3D'width:81.85pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:20.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1800<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dtop style=3D'width:87.1pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:20.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>18<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dtop style=3D'width:92.4pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:20.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>18<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dtop style=3D'width:87.6pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-left-alt:solid windowtext .5pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-bottom-alt:solid windowtext .25pt;mso-border-right-alt:solid w=
indowtext .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:20.85pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>36<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.35pt'>
  <td width=3D103 rowspan=3D3 valign=3Dtop style=3D'width:77.3pt;border:sol=
id windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .5pt;mso-border-top-alt:solid windowtext .25pt;backgroun=
d:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span class=3DSimSun><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman",serif'>&=
#8805;
  </span></span></span></span><span style=3D'mso-bookmark:_Hlk171502791'><s=
pan
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>100<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>600<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>6<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:87.6pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>12<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:11.35pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1500<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>15<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 valign=3Dbottom style=3D'width:87.6pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>30<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
 <tr style=3D'mso-yfti-irow:9;mso-yfti-lastrow:yes;height:11.35pt'>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D109 valign=3Dbottom style=3D'width:81.85pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>1800<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D116 valign=3Dbottom style=3D'width:87.1pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>18<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D123 valign=3Dbottom style=3D'width:92.4pt;border-top:none;bor=
der-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>18<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
  <td width=3D117 style=3D'width:87.6pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span style=3D'mso-bookmark:_Hlk171502791'><span
  style=3D'mso-bookmark:_Hlk171502774'><span lang=3DUK style=3D'mso-bidi-fo=
nt-size:
  12.0pt'>36<o:p></o:p></span></span></span></p>
  </td>
  <span style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_H=
lk171502774'></span></span>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>а</span></sup></span></span><=
span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> Маса тіла на момент лікуванн=
я.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>б </span></sup></span></span>=
<span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс с=
лід
розводити тільки розчином натрію хлориду 9&nbsp;мг/мл (0,9&nbsp;%) для
ін’єкцій.<o:p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Будь-який невикористаний ліка=
рський засіб
та відпрацьований матеріал слід утилізувати згідно з місцевими вимогами.<o:=
p></o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk171502791'><span style=3D'mso-bookmark:_Hlk171502=
774'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Взаємодія з іншими лікарським=
и засобами
та інші види взаємодій<span style=3D'mso-bidi-font-weight:bold;mso-bidi-fon=
t-style:
italic'><o:p></o:p></span></span></i></b></span></span></p>

<span style=3D'mso-bookmark:_Hlk171502774'></span><span style=3D'mso-bookma=
rk:_Hlk171502791'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клінічні дослідження взаємоді=
ї з
іншими лікарськими засобами не проводилися. З огляду на потенційний інгібую=
чий
вплив равулізумабу на комплементозалежну цитотоксичність ритуксимабу
равулізумаб може зменшити очікувані фармакодинамічні ефекти ритуксимабу.<o:=
p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Довготривале лікування
внутрішньовенним імуноглобуліном людини (в/вІГ) може порушувати механізм
рециркуляції ендосомального неонатального Fc-рецептора (FcRn) моноклональних
антитіл, таких як равулізумаб, і, таким чином, знижувати концентрацію
равулізумабу в сироватці крові. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рекомендації для випадків зас=
тосування
лікарського засобу одночасно з плазмообміном (ПО), плазмаферезом (ПФ) та вн=
утрішньовенним
введення імуноглобуліну (в/вІГ) наведені в розділі «Спосіб застосування та
дози». </span><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareas=
t-language:
EN-US;mso-bidi-language:EN-US'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk171516300"><b><i style=3D'mso-bidi-font-style:normal'><span lan=
g=3DUK
style=3D'mso-bidi-font-size:12.0pt'>Особливості застосування</span></i></b>=
</a><b><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'><o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Простежуваність<o:p></o:p></s=
pan></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Щоб полегшити відстеження біо=
логічних
лікарських засобів, необхідно чітко зазначати назву та номер серії засобу, =
що
застосовувався, у медичній документації пацієнта.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Серйозна менінгококова інфекц=
ія<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Через механізм дії равулізума=
бу його
застосування підвищує сприйнятливість пацієнтів до менінгококової інфекції =
/ сепсису
(<i>Neisseria meningitidis</i>). Може виникнути менінгококова інфекція,
спричинена збудником будь-якої серологічної групи, див. розділ «Побічні
реакції». З метою зниження ризику інфекції всі пацієнти мають бути вакцинов=
ані
проти менінгококової інфекції принаймні за два тижні до початку лікування
равулізумабом, якщо тільки ризик відтермінування початку лікування
равулізумабом не перевищує ризику розвитку менінгококової інфекції. Пацієнт=
и,
які розпочинають лікування равулізумабом менш ніж через 2 тижні після
вакцинації проти менінгококової інфекції, повинні отримувати профілактичне
лікування відповідними антибіотиками, доки з моменту вакцинації не мине 2
тижні. Для профілактики менінгококової інфекції, спричиненої найпоширенішими
патогенними серологічними групами, рекомендують вакцини проти всіх наявних =
серологічних
груп, включаючи А, С, Y, W135 і В. Пацієнти мають бути вакциновані та ревак=
циновані
згідно з чинними національними рекомендаціями щодо вакцинації. При переведе=
нні
пацієнта з лікування екулізумабом лікарі повинні переконатися в тому, що
вакцинацію проти менінгококової інфекції проводять відповідно до чинних
національних рекомендацій з вакцинації.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Для запобігання розвитку
менінгококової інфекції вакцинації може бути недостатньо. Слід звернути ува=
гу
на офіційні рекомендації щодо відповідного застосування антибактеріальних
лікарських засобів. Повідомлялося про випадки серйозної чи летальної
менінгококової інфекції / сепсису в пацієнтів, які отримували лікування
равулізумабом, та в пацієнтів, які отримували лікування іншими інгібіторами
термінальних компонентів комплементу. Слід спостерігати за станом усіх паці=
єнтів
щодо виявлення ранніх ознак менінгококової інфекції чи сепсису та при підоз=
рі
на їх виникнення слід негайно обстежити пацієнта та розпочати лікування
відповідними антибіотиками. Пацієнтів слід проінформувати про ці ознаки та
симптоми, а про необхідність негайного звернення по медичну допомогу. Лікарі
повинні надавати пацієнтам посібник для пацієнтів та картку пацієнта.<o:p><=
/o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Імунізація<o:p></o:p></span><=
/u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Перед початком терапії равулі=
зумабом
пацієнтам рекомендується провести імунізацію відповідно до чинних рекоменда=
цій
щодо імунізації.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вакцинація може спричинити до=
даткову
активацію комплементу. У результаті в пацієнтів із комплементопосередковани=
ми
захворюваннями можливе посилення ознак та симптомів їхнього основного
захворювання, наприклад гемолізу. Отже, слід ретельно контролювати симптоми
захворювання в пацієнтів після рекомендованої вакцинації.<o:p></o:p></span>=
</p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти віком до 18 років по=
винні
бути вакциновані проти інфекції, спричиненої <i>Haemophilus influenzae</i>,=
 і
пневмококової інфекції та мають суворо дотримуватися рекомендацій національ=
ного
календаря профілактичних щеплень для їхньої вікової групи.<o:p></o:p></span=
></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інші генералізовані інфекції<=
o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікування равулізумабом паціє=
нтів з
активними генералізованими інфекціями слід проводити з обережністю. Равуліз=
умаб
блокує активацію термінальних компонентів комплементу, тому у пацієнтів може
бути підвищена сприйнятливість до інфекцій, спричинених видами <i>Neisseria=
</i>
та інкапсульованими бактеріями. Повідомлялося про серйозні інфекції, спричи=
нені
видами <i>Neisseria</i> (крім <i>Neisseria</i> <i>meningitidis</i>), включа=
ючи
дисеміновані гонококові інфекції.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам слід надати інформа=
цію з інструкції
для медичного застосування для підвищення обізнаності щодо можливих тяжких
інфекцій, а також їхніх ознак і симптомів. Лікарі повинні надати пацієнтам =
поради
щодо профілактики гонореї.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інфузійні реакції<o:p></o:p><=
/span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу може
призвести до виникнення системних інфузійних реакцій, а також алергічних ре=
акцій
або реакцій гіперчутливості, включаючи анафілаксію, див. розділ «Побічні
реакції».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У разі розвитку системної інф=
узійної
реакції, при появі ознак нестабільності функції серцево-судинної системи чи
дихальної недостатності, введення равулізумабу слід припинити та вжити
відповідних підтримуючих заходів.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Припинення лікування пацієнті=
в із ПНГ<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Якщо пацієнти з ПНГ припиняють
терапію равулізумабом, їхній стан слід ретельно контролювати щодо появи озн=
ак і
симптомів серйозного внутрішньосудинного гемолізу, що визначається за
підвищенням активності ЛДГ (лактатдегідрогенази) разом із раптовим зменшенн=
ям
розміру клону ПНГ або зниженням концентрації гемоглобіну, або за поновленням
таких симптомів, як втомлюваність, гемоглобінурія, біль у животі, задишка,
серйозні небажані судинні явища (включно з тромбозом), дисфагія чи еректиль=
на
дисфункція. Стан усіх пацієнтів, які припинили терапію равулізумабом, слід
контролювати протягом щонайменше 16 тижнів з метою виявлення гемолізу та ін=
ших
реакцій. Якщо після припинення терапії з’являються ознаки та симптоми гемол=
ізу,
включаючи підвищення активності ЛДГ, слід оцінити необхідність відновлення
терапії равулізумабом.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Припинення лікування пацієнті=
в з аГУС<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Специфічні дані щодо припинен=
ня
терапії равулізумабом відсутні. У довгостроковому проспективному спостережн=
ому
дослідженні дострокове припинення лікування інгібітором комплементу С5
(екулізумабом) призвело до збільшення частоти рецидивів ТМА (тромботична
мікроангіопатія) у 13,5 раза та виявило тенденцію до зниження функції нирок=
 порівняно
з такими у пацієнтів, які продовжували лікування.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Якщо пацієнти повинні припини=
ти
терапію равулізумабом, їхній стан слід постійно ретельно контролювати щодо
ознак і симптомів ТМА. Проте контроль може бути недостатнім для прогнозуван=
ня тяжких
ускладнень ТМА або запобігання їм.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ускладнення ТМА після припине=
ння
лікування можуть бути виявлені, якщо спостерігаються будь-які з таких ознак=
:<o:p></o:p></span></p>

<p class=3DMsoListParagraphCxSpFirst style=3D'margin-top:0cm;margin-right:0=
cm;
margin-bottom:0cm;margin-left:21.8pt;margin-bottom:.0001pt;mso-add-space:au=
to;
text-align:justify;text-indent:-21.8pt;mso-list:l24 level1 lfo27'><![if !su=
pportLists]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>-<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span></span></span><![endif]><span lang=3DUK style=3D'mso-bidi-font-size:=
12.0pt'>Щонайменше
2 результати лабораторних досліджень спостерігаються одночасно: зниження
кількості тромбоцитів на 25&nbsp;% або більше порівняно з вихідним рівнем а=
бо з
найбільшим зареєстрованим значенням під час терапії равулізумабом; підвищен=
ня
концентрації креатиніну в сироватці на 25&nbsp;% або більше порівняно з
вихідним рівнем або з найменшим зареєстрованим значенням у ході терапії
равулізумабом; підвищення активності ЛДГ у сироватці на 25&nbsp;% або більше
порівняно з вихідною активністю або з найменшим зареєстрованим значенням
(результати повинні бути підтверджені повторним вимірюванням).<o:p></o:p></=
span></p>

<p class=3DMsoListParagraphCxSpLast style=3D'margin-top:0cm;margin-right:0c=
m;
margin-bottom:0cm;margin-left:21.3pt;margin-bottom:.0001pt;mso-add-space:au=
to;
text-align:justify'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:=
p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'>Або<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoListParagraph style=3D'margin-top:0cm;margin-right:0cm;margin=
-bottom:
0cm;margin-left:14.2pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:
justify;text-indent:-14.2pt;mso-list:l24 level1 lfo27'><![if !supportLists]=
><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-list:Ignor=
e'>-<span
style=3D'font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;=
 </span></span></span><![endif]><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Один із таких симптомів ТМА: =
зміна
психічного статусу, судомні напади або інші позаниркові прояви ТМА, включаю=
чи
порушення з боку серцево-судинної системи, перикардит, симптоми з боку
шлунково-кишкового тракту/діарею або тромбоз.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Якщо ускладнення ТМА виникли =
після
припинення терапії равулізумабом, слід оцінити необхідність відновлення тер=
апії
равулізумабом, починаючи з навантажувальної дози та продовжуючи у
підтримувальній дозі, див. розділ «Спосіб застосування та дози».<o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Припинення лікування пацієнті=
в із гМГ<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зважаючи на те, що гМГ є хрон=
ічним захворюванням,
пацієнти, які отримують користь від лікування равулізумабом і припиняють
лікування, повинні перебувати під наглядом для виявлення симптомів основного
захворювання. Якщо після припинення терапії з’являються симптоми гМГ, слід
оцінити необхідність відновлення терапії равулізумабом.<o:p></o:p></span></=
p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Припинення лікування пацієнті=
в із ОНМРС<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зважаючи на те, що ОНМРС є хр=
онічним
захворюванням, пацієнти, які отримують користь від лікування равулізумабом і
припиняють лікування, повинні перебувати під наглядом для виявлення симптом=
ів
рецидиву ОНМРС. Якщо після припинення терапії з’являються симптоми рецидиву=
 ОНМРС,
слід оцінити необхідність відновлення терапії равулізумабом.<o:p></o:p></sp=
an></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Перехід з екулізумабу на раву=
лізумаб<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам із гМГ, у яких відс=
утня
відповідь на затверджений режим дозування екулізумабу, лікування равулізума=
бом
не рекомендується.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вміст натрію<o:p></o:p></span=
></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс п=
ісля
розведення 9&nbsp;мг/мл (0,9 %) розчином натрію хлориду для ін’єкцій містить
0,18&nbsp;г натрію у 72&nbsp;мл розчину в максимальній дозі, що еквівалентно
9,1&nbsp;% рекомендованої ВООЗ максимальної добової дози 2&nbsp;г натрію для
дорослої людини.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вміст полісорбату 80<o:p></o:=
p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб містить 1,5 =
мг
полісорбату 80 в одному флаконі об’ємом 3 мл та 5,5 мг в одному флаконі об’=
ємом
11 мл, що еквівалентно &#8804; 0,453 мг/кг у максимальній дозі для дорослих
пацієнтів та дітей з масою тіла більше 10 кг. Полісорбати можуть викликати
алергічні реакції.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування у період вагітно=
сті або
годування груддю<o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Жінки репродуктивного віку<o:=
p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Під час терапії та протягом 8=
 місяців
після терапії жінкам репродуктивного віку слід використовувати ефективні ме=
тоди
контрацепції.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вагітність<o:p></o:p></span><=
/u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клінічні дані про застосування
равулізумабу вагітним жінкам відсутні.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Доклінічні токсикологічні дос=
лідження
впливу равулізумабу на репродуктивну функцію не проводилися, див. розділ
«Фармакологічні властивості». Дослідження токсичного впливу на репродуктивну
функцію у мишей були проведені із використанням мишачої сурогатної молекули
ВВ5.1, в яких було оцінено вплив блокування С5 на репродуктивну систему.
Специфічних токсичних ефектів щодо репродуктивної системи, пов’язаних із до=
сліджуваною
речовиною, не було виявлено. Відомо, що імуноглобулін людини G (IgG) здатний
проникати через плацентарний бар’єр людини. Таким чином, равулізумаб потенц=
ійно
може спричиняти інгібування термінальних компонентів комплементу в циркулюю=
чій
крові плода.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Даних доклінічних досліджень =
на
тваринах недостатньо для оцінки токсичного впливу на репродуктивну функцію,
див. розділ «Фармакологічні властивості».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу ваг=
ітним
жінкам може бути розглянуто після оцінки співвідношення ризик/користь.<o:p>=
</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Годування груддю<o:p></o:p></=
span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Невідомо, чи виділяється раву=
лізумаб
з грудним молоком. У доклінічних дослідженнях токсичного впливу на
репродуктивну функцію у мишей, проведених із мишачою сурогатною молекулою
ВВ5.1, не виявлено небажаних ефектів у дитинчат унаслідок споживання молока=
 від
самок, які отримали лікарський засіб.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ризик для немовлят не може бу=
ти
виключений.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Оскільки велика кількість лік=
арських засобів
та імуноглобулінів секретується у грудне молоко та з огляду на можливості
розвитку серйозних небажаних реакцій у немовлят, грудне вигодовування слід
припинити на період лікування равулізумабом та протягом 8 місяців після так=
ого лікування.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Фертильність<o:p></o:p></span=
></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Доклінічні дослідження впливу
равулізумабу на фертильність не проводилися.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У доклінічних дослідженнях то=
ксичного
впливу на репродуктивну функцію у мишей, проведених із мишачою сурогатною
молекулою (ВВ5.1), не виявлено небажаних ефектів щодо репродуктивної системи
самок або самців, які отримали лікарський засіб.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'mso-bidi-=
font-size:
12.0pt'>Здатність впливати на швидкість реакції при керуванні автотранспорт=
ом
або іншими механізмами<o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс не
впливає або має незначний вплив на здатність керувати автотранспортом і
працювати з іншими механізмами.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'><o:p>&nbsp;</o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>Спосіб застосування та дози<o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Равулізумаб повинен призначат=
ися
лікарем, який має досвід лікування пацієнтів з гематологічними, нирковими,
нервово-м’язовими або нейрозапальними захворюваннями, та застосовуватися під
наглядом такого лікаря.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дозування<o:p></o:p></span></=
u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дорослі пацієнти з ПНГ, аГУС,=
 гМГ або
ОНМРС<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Рекомендований режим дозування
складається з навантажувальної дози з подальшим застосуванням лікарського
засобу в підтримувальних дозах, що вводяться шляхом внутрішньовенної інфузі=
ї.
Вибір дози лікарського засобу залежить від маси тіла пацієнта, як показано =
в таблиці&nbsp;19.
Дорослим пацієнтам (&#8805; 18&nbsp;років) підтримувальні дози лікарського
засобу слід вводити один раз кожні 8 тижнів, при цьому початкова підтримува=
льна
доза вводиться через 2 тижні після введення навантажувальної дози.<o:p></o:=
p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дозволяється час від часу змі=
нювати
графік дозування на ± 7 днів від запланованого дня інфузії (за винятком пер=
шої
підтримувальної дози равулізумабу), але наступну дозу слід вводити згідно з
початковим графіком.<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця&nbsp;19<span
style=3D'mso-tab-count:1'>    </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Режим дозування равулізумабу =
залежно
від маси тіла для дорослих пацієнтів, маса тіла яких становить &#8805;&nbsp=
;40
кг<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D620
 style=3D'width:465.15pt;margin-left:5.65pt;border-collapse:collapse;border=
:none;
 mso-border-alt:solid windowtext .25pt;mso-table-overlap:never;mso-padding-=
alt:
 0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid windowtext;mso-border-ins=
idev:
 .25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:11.9pt'>
  <td width=3D168 valign=3Dtop style=3D'width:125.75pt;border:solid windowt=
ext 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:.95pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Діапазон маси тіла (кг)<b><=
o:p></o:p></b></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:98.9pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.5pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Навантажувальна доза (мг)<b=
><o:p></o:p></b></span></p>
  </td>
  <td width=3D168 valign=3Dtop style=3D'width:126.0pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
8.8pt;
  margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:center=
'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Підтримувальна доза (мг)*<b=
><o:p></o:p></b></span></p>
  </td>
  <td width=3D153 valign=3Dtop style=3D'width:114.5pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.35pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Періодичність введення<b><o=
:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:8.5pt'>
  <td width=3D168 valign=3Dtop style=3D'width:125.75pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40 до &lt; 60<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:98.9pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
00<o:p></o:p></span></p>
  </td>
  <td width=3D168 valign=3Dtop style=3D'width:126.0pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
00<o:p></o:p></span></p>
  </td>
  <td width=3D153 valign=3Dtop style=3D'width:114.5pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:8.5pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 8
  тижнів<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D168 valign=3Dtop style=3D'width:125.75pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60 до &lt; 100<o:p></o:p></=
span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:98.9pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>27=
00<o:p></o:p></span></p>
  </td>
  <td width=3D168 valign=3Dtop style=3D'width:126.0pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>33=
00<o:p></o:p></span></p>
  </td>
  <td width=3D153 valign=3Dtop style=3D'width:114.5pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 8
  тижнів<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D168 valign=3Dtop style=3D'width:125.75pt;border:solid windowt=
ext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>100</span><span class=3DSim=
Sun><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt;font-family:"Times New Roman=
",serif'><o:p></o:p></span></span></p>
  </td>
  <td width=3D132 valign=3Dtop style=3D'width:98.9pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
00<o:p></o:p></span></p>
  </td>
  <td width=3D168 valign=3Dtop style=3D'width:126.0pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>36=
00<o:p></o:p></span></p>
  </td>
  <td width=3D153 valign=3Dtop style=3D'width:114.5pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 8
  тижнів<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>* Перша підтримувальна доза л=
ікарського
засобу вводиться через 2 тижні після введення навантажувальної дози.<o:p></=
o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інструкції щодо початку лікув=
ання
пацієнтів, які не отримували лікування інгібіторами комплементу чи переходя=
ть з
лікування екулізумабом наведені в таблиці 20.<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 20 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інструкції щодо початку лікув=
ання
равулізумабом<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D633
 style=3D'width:474.5pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .5pt;
 mso-table-overlap:never;mso-padding-alt:4.25pt 5.65pt 0cm 5.65pt;mso-borde=
r-insideh:
 .5pt solid windowtext;mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:41.1pt'>
  <td width=3D191 valign=3Dtop style=3D'width:143.5pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:4.25pt 5.65=
pt 0cm 5.65pt;
  height:41.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Популяція пацієнтів<b><o:p>=
</o:p></b></span></p>
  </td>
  <td width=3D211 valign=3Dtop style=3D'width:157.95pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;background:white;padding:4.25pt 5.65pt 0cm 5.65pt;
  height:41.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Навантажувальна&nbsp;доза
  равулізумабу з огляду на масу тіла<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D231 valign=3Dtop style=3D'width:173.05pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
  solid windowtext .5pt;background:white;padding:4.25pt 5.65pt 0cm 5.65pt;
  height:41.1pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Час введення першої підтрим=
увальної&nbsp;дози
  равулізумабу з огляду на масу тіла<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:27.5pt'>
  <td width=3D191 valign=3Dtop style=3D'width:143.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  background:white;padding:4.25pt 5.65pt 0cm 5.65pt;height:27.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нині не отримують лікування
  равулізумабом або екулізумабом<o:p></o:p></span></p>
  </td>
  <td width=3D211 valign=3Dtop style=3D'width:157.95pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:4.25pt 5.65=
pt 0cm 5.65pt;
  height:27.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>На початку лікування<o:p></=
o:p></span></p>
  </td>
  <td width=3D231 valign=3Dtop style=3D'width:173.05pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:4.25pt 5.65=
pt 0cm 5.65pt;
  height:27.5pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2&nbsp;тижні&nbsp;після
  навантажувальної</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.=
0pt;
  mso-ansi-language:EN-US'>&nbsp;</span><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt'>дози равулізумабу<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;mso-yfti-lastrow:yes;height:28.65pt'>
  <td width=3D191 valign=3Dtop style=3D'width:143.5pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:s=
olid windowtext .5pt;
  background:white;padding:4.25pt 5.65pt 0cm 5.65pt;height:28.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нині отримують лікування
  екулізумабом<o:p></o:p></span></p>
  </td>
  <td width=3D211 valign=3Dtop style=3D'width:157.95pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:4.25pt 5.65=
pt 0cm 5.65pt;
  height:28.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>На момент наступної планово=
ї дози
  екулізумабу<o:p></o:p></span></p>
  </td>
  <td width=3D231 valign=3Dtop style=3D'width:173.05pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:4.25pt 5.65=
pt 0cm 5.65pt;
  height:28.65pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2&nbsp;тижні&nbsp;після
  навантажувальної</span><span lang=3DEN-US style=3D'mso-bidi-font-size:12.=
0pt;
  mso-ansi-language:EN-US'>&nbsp;</span><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
  12.0pt'>дози равулізумабу<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Діти з ПНГ чи аГУС<o:p></o:p>=
</span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти дитячого віку з масо=
ю тіла
&#8805; 40&nbsp;кг<o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Цих пацієнтів слід лікувати
відповідно до рекомендацій щодо дозування для дорослих (див.&nbsp;таблицю 1=
9).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти дитячого віку з масо=
ю тіла
від </span></u></i><span class=3DSimSun><i><u><span lang=3DUK style=3D'mso-=
bidi-font-size:
12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></u></i></span><=
i><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10&nbsp;кг до &lt; 40&nbsp;кг=
<o:p></o:p></span></u></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дози та інтервали між введенн=
ями для
пацієнтів дитячого віку з масою тіла від &#8805; 10&nbsp;кг до
&lt;&nbsp;40&nbsp;кг наведені в таблиці 21.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам, які переходять з
екулізумабу на равулізумаб, навантажувальну дозу равулізумабу слід вводити
через 2 тижні після останнього введення екулізумабу. </span><span lang=3DUK
style=3D'font-size:11.0pt;mso-bidi-font-size:12.0pt'>Ч</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>ерез 2 тижні після навантажувальної дози
починають вводити підтримувальні дози за схемою дозування з урахуванням маси
тіла, наведеною в таблиці 21.<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fa=
reast-language:
EN-US;mso-bidi-language:EN-US'>Таблиця 21<span style=3D'mso-tab-count:1'>  =
  </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Режим дозування равулізумабу =
залежно
від маси тіла для пацієнтів дитячого віку з ПНГ або аГУС з масою тіла <span
style=3D'mso-bidi-font-style:italic'>&lt; </span>40 кг</span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso-bidi-lang=
uage:
EN-US'><o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:453.85pt;border-collapse:collapse;border:none;mso-border-al=
t:
 solid windowtext .25pt;mso-table-overlap:never;mso-padding-alt:0cm .5pt 0c=
m .5pt;
 mso-border-insideh:.25pt solid windowtext;mso-border-insidev:.25pt solid w=
indowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:12.75pt'>
  <td width=3D173 valign=3Dtop style=3D'width:130.1pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:12.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ді=
апазон
  маси тіла (кг)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D141 valign=3Dtop style=3D'width:105.85pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  12.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>На=
вантажувальна
  доза (мг)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D171 valign=3Dtop style=3D'width:128.4pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  12.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пі=
дтримувальна
  доза (мг)</span><!--[if supportFields]><b><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt'><span style=3D'mso-element:field-begin'></span></span></b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> REF First_maintenance \h<s=
pan
  style=3D'mso-spacerun:yes'>  </span>\* MERGEFORMAT <b><span style=3D'mso-=
element:
  field-separator'></span></b></span><![endif]--><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'>*<b><!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B020000000800000012000000460069=
007200730074005F006D00610069006E00740065006E0061006E00630065000000</w:data>
  </xml><![endif]--></b></span><!--[if supportFields]><b><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></b><![endif]--><b><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></b></p>
  </td>
  <td width=3D119 valign=3Dtop style=3D'width:89.5pt;border:solid windowtex=
t 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  12.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пе=
ріодичність
  введення<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.35pt'>
  <td width=3D173 style=3D'width:130.1pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10 до &lt; 20<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D141 style=3D'width:105.85pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60=
0<o:p></o:p></span></p>
  </td>
  <td width=3D171 style=3D'width:128.4pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60=
0<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 4
  тижні<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D173 style=3D'width:130.1pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20 до &lt; 30<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D141 style=3D'width:105.85pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>90=
0<o:p></o:p></span></p>
  </td>
  <td width=3D171 style=3D'width:128.4pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>21=
00<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 8
  тижнів<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D173 style=3D'width:130.1pt;border:solid windowtext 1.0pt;bord=
er-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30 до &lt; 40<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D141 style=3D'width:105.85pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
00<o:p></o:p></span></p>
  </td>
  <td width=3D171 style=3D'width:128.4pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>27=
00<o:p></o:p></span></p>
  </td>
  <td width=3D119 style=3D'width:89.5pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ко=
жні 8
  тижнів<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"First_maintenance"><sup><span lang=3DUK style=3D'mso-bidi-font-size=
:12.0pt'>*</span></sup></a><span
style=3D'mso-bookmark:First_maintenance'></span><span lang=3DUK style=3D'ms=
o-bidi-font-size:
12.0pt'> Перша підтримувальна доза лікарського засобу вводиться через 2 тиж=
ні
після введення навантажувальної дози.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу пац=
ієнтам
дитячого віку з ПНГ з масою тіла <span style=3D'mso-bidi-font-style:italic'=
>&lt; </span>30
кг не вивчалося. Режим дозування равулізумабу для<span
style=3D'mso-spacerun:yes'>  </span>пацієнтів з масою тіла <span
style=3D'mso-bidi-font-style:italic'>&lt;</span> 30 кг базується на режимі
дозування для пацієнтів дитячого віку з аГУС з урахуванням даних
фармакокінетики/ фармакодинаміки (ФК/ФД) у пацієнтів з аГУС і ПНГ, які
отримували равулізумаб.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>ПНГ є хронічним захворюванням=
, і
лікування равулізумабом рекомендується протягом усього життя пацієнта за
відсутності клінічних показань для припинення застосування равулізумабу, ди=
в.
розділ «Особливості застосування».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>При аГУС лікування равулізума=
бом для
усунення проявів тромботичної мікроангіопатії (ТМА) повинно тривати протягом
щонайменше 6 місяців, після чого тривалість лікування необхідно визначати д=
ля
кожного пацієнта індивідуально. Пацієнтам із високим ризиком рецидиву ТМА за
оцінкою лікаря (або за клінічними показаннями) може бути потрібна тривала
терапія, див. розділ «Особливості застосування».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У дорослих пацієнтів з гМГ аб=
о ОНМРС
лікування равулізумабом вивчалося лише при тривалому застосуванні, див. роз=
діл
«Особливості застосування».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу пац=
ієнтам з
гМГ класу V за класифікацією MGFA не вивчалося.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Додаткове введення лікарськог=
о засобу
після плазмообміну (ПО), плазмаферезу (ПФ) або внутрішньовенного введення
імуноглобуліну (в/вІГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Було показано, що плазмообмін=
 (ПО),
плазмаферез (ПФ) та внутрішньовенне введення імуноглобуліну (в/вІГ) знижують
сироваткові концентрації равулізумабу. У разі ПО, ПФ або в/вІГ потрібне
введення додаткової дози равулізумабу (таблиця 22).<o:p></o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 22 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Додаткова доза равулізумабу п=
ісля ПО,
ПФ або в/вІГ<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:453.9pt;border-collapse:collapse;border:none;mso-border-top=
-alt:
 .25pt;mso-border-left-alt:.25pt;mso-border-bottom-alt:.5pt;mso-border-righ=
t-alt:
 .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;mso-table-=
overlap:
 never;mso-padding-alt:0cm .5pt 0cm .5pt;mso-border-insideh:.25pt solid win=
dowtext;
 mso-border-insidev:.5pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:48.75pt'>
  <td width=3D116 valign=3Dtop style=3D'width:86.9pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .25pt;mso-border-right-alt:solid windowte=
xt .5pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:48.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ді=
апазон
  маси тіла (кг)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D136 valign=3Dtop style=3D'width:102.0pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm .5pt 0cm .5pt;height:48.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
4.4pt;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Остання доза равулізумабу<b=
><o:p></o:p></b></span></p>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
4.4pt;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(мг)<b><o:p></o:p></b></spa=
n></p>
  </td>
  <td width=3D177 valign=3Dtop style=3D'width:132.5pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm .5pt 0cm .5pt;height:48.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
9.25pt;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Додаткова доза (мг) після к=
ожної
  процедури ПО або ПФ<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D177 valign=3Dtop style=3D'width:132.5pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-top=
-alt:
  .25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.25pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm .5pt 0cm .5pt;height:48.75pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
7.0pt;
  margin-bottom:0cm;margin-left:3.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Додаткова доза (мг) після
  завершення циклу в/вІГ<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:14.15pt'>
  <td width=3D116 rowspan=3D2 style=3D'width:86.9pt;border:solid windowtext=
 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#=
8805; 40
  до &lt; 60<o:p></o:p></span></p>
  </td>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2400<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1200<o:p></o:p></span></p>
  </td>
  <td width=3D177 rowspan=3D2 style=3D'width:132.5pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:14.15pt'>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3000<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:14.15pt'>
  <td width=3D116 rowspan=3D2 style=3D'width:86.9pt;border:solid windowtext=
 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#=
8805; 60
  до &lt; 100<o:p></o:p></span></p>
  </td>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>2700<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
  <td width=3D177 rowspan=3D2 style=3D'width:132.5pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:14.15pt'>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3300<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1800<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:14.15pt'>
  <td width=3D116 rowspan=3D2 style=3D'width:86.9pt;border:solid windowtext=
 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;mso-border-right-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#=
8805;
  100<o:p></o:p></span></p>
  </td>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3000<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
  <td width=3D177 rowspan=3D2 style=3D'width:132.5pt;border-top:none;border=
-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:14.15pt'>
  <td width=3D136 valign=3Dbottom style=3D'width:102.0pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:4.45pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>3600<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dbottom style=3D'width:132.5pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-top-alt:.25pt;mso-border-left-alt:.5pt;mso-border-bottom-alt:.=
25pt;
  mso-border-right-alt:.5pt;mso-border-color-alt:windowtext;mso-border-styl=
e-alt:
  solid;background:white;padding:0cm .5pt 0cm .5pt;height:14.15pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.1pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1800<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;mso-yfti-lastrow:yes;height:26.95pt'>
  <td width=3D252 colspan=3D2 valign=3Dtop style=3D'width:188.9pt;border:so=
lid windowtext 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-top-=
alt:
  .25pt;mso-border-left-alt:.25pt;mso-border-bottom-alt:.5pt;mso-border-rig=
ht-alt:
  .5pt;mso-border-color-alt:windowtext;mso-border-style-alt:solid;backgroun=
d:
  white;padding:0cm 5.65pt 0cm 5.65pt;height:26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ча=
с введення
  додаткової дози равулізумабу<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D177 valign=3Dtop style=3D'width:132.5pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm 5.65pt 0cm 5.65pt;height:26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пр=
отягом 4
  годин після кожної процедури ПО або ПФ<o:p></o:p></span></p>
  </td>
  <td width=3D177 valign=3Dtop style=3D'width:132.5pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .5pt;
  mso-border-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext =
.25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:26.95pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пр=
отягом 4
  годин після завершення циклу в/вІГ<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>в/вІГ — внутрішньовенний
імуноглобулін, кг — кілограм, ПО — плазмообмін, ПФ — плазмаферез<o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:EN-US;mso=
-bidi-language:
EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Особливі групи пацієнтів<o:p>=
</o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнти літнього віку<o:p></=
o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам із ПНГ, аГУС, гМГ а=
бо ОНМРС
віком &#8805; 65 років корекція дози не потрібна. Відсутні докази, що вказу=
ють
на необхідність будь-яких спеціальних запобіжних заходів при лікуванні
пацієнтів літнього віку, хоча досвід застосування равулізумабу літнім паціє=
нтам
з ПНГ, аГУС або ОНМРС у клінічних дослідженнях обмежений.<o:p></o:p></span>=
</p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення функції нирок<o:p><=
/o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам із порушеннями функ=
ції
нирок корекція дози не потрібна, див. розділ «Фармакологічні властивості».<=
o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення функції печінки<o:p=
></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність і безпеку застос=
ування
равулізумабу пацієнтам із порушенням функції печінки не вивчали; однак на
підставі фармакокінетичних даних припускають, що пацієнтам із порушенням
функції печінки корекція дози не потрібна.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk207794376"><u><span lang=3DUK style=3D'mso-bidi-font-size:12.0p=
t'><o:p><span
 style=3D'text-decoration:none'>&nbsp;</span></o:p></span></u></a></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Hlk207794376'><u><span lang=3DUK style=3D'mso-bidi-f=
ont-size:
12.0pt'>Педіатрична популяція</span></u></span><span style=3D'mso-bookmark:=
_Hlk207794376'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> <o:p></o:p></span></span></p>

<span style=3D'mso-bookmark:_Hlk207794376'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність і безпеку застос=
ування равулізумабу
дітям з масою тіла &lt;&nbsp;10 кг з ПНГ та аГУС не встановлено. Доступних =
на
сьогодні даних, описаних у розділі «Побічні реакції», недостатньо, щоб
встановити рекомендації щодо дозування дітям.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність і безпеку застос=
ування
равулізумабу дітям з гМГ чи ОНМРС не встановлено. Дані відсутні.<o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Спосіб застосування<o:p></o:p=
></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Для внутрішньовенного застосу=
вання
після розведення концентрату для розчину для інфузій. Тільки для
внутрішньовенного інфузійного введення. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб необхідно вв=
одити через
фільтр 0,2&nbsp;мкм і не слід вводити внутрішньовенно струминно або болюсно.
Після введення лікарського засобу Ультоміріс необхідно промити систему для
внутрішньовенного введення розчином натрію хлориду 0,9&nbsp;% для ін’єкцій.=
<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб Ультоміріс, =
концентрат
для розчину для інфузій, представлений у флаконах по 3&nbsp;мл і 11&nbsp;мл=
 і
має бути розведений до кінцевої концентрації 50&nbsp;мг/мл. Після розведенн=
я лікарський
засіб Ультоміріс вводять за допомогою внутрішньовенної інфузії з використан=
ням
шприцевого насоса або інфузійного насоса протягом мінімального періоду часу=
 від
0,17 до 1,3 години (від 10 до 75 хвилин) залежно від маси тіла (див. таблиц=
і 23
і 24 нижче).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 23 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тривалість введення лікарсько=
го
засобу Ультоміріс <o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0
 style=3D'margin-left:5.65pt;border-collapse:collapse;border:none;mso-borde=
r-alt:
 solid windowtext .25pt;mso-table-overlap:never;mso-padding-alt:0cm .5pt 0c=
m .5pt;
 mso-border-insideh:.25pt solid windowtext;mso-border-insidev:.25pt solid w=
indowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:38.0pt'>
  <td width=3D110 valign=3Dtop style=3D'width:82.3pt;border:solid windowtex=
t 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 2.85pt=
 0cm 2.85pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ді=
апазон
  маси тіла (кг)<sup>a</sup><b><o:p></o:p></b></span></p>
  </td>
  <td width=3D138 valign=3Dtop style=3D'width:103.3pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 2.85pt 0cm 2.85pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>На=
вантажувальна
  доза (мг)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D113 valign=3Dtop style=3D'width:3.0cm;border:solid windowtext=
 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 2.85pt 0cm 2.85pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
німальна
  тривалість інфузійного введення, хвилини (години)<b><o:p></o:p></b></span=
></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 2.85pt 0cm 2.85pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пі=
дтримувальна
  доза (мг)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D123 valign=3Dtop style=3D'width:92.15pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 2.85pt 0cm 2.85pt;
  height:38.0pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мі=
німальна
  тривалість інфузійного введення, хвилини (години)<b><o:p></o:p></b></span=
></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.35pt'>
  <td width=3D110 style=3D'width:82.3pt;border:solid windowtext 1.0pt;borde=
r-top:
  none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:solid windo=
wtext .25pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10 до &lt; 20<sup>а</sup><o=
:p></o:p></span></p>
  </td>
  <td width=3D138 style=3D'width:103.3pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60=
0<o:p></o:p></span></p>
  </td>
  <td width=3D113 style=3D'width:3.0cm;border-top:none;border-left:none;bor=
der-bottom:
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top=
-alt:
  solid windowtext .25pt;mso-border-left-alt:solid windowtext .25pt;mso-bor=
der-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
 (0,8)<o:p></o:p></span></p>
  </td>
  <td width=3D142 style=3D'width:106.3pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60=
0<o:p></o:p></span></p>
  </td>
  <td width=3D123 style=3D'width:92.15pt;border-top:none;border-left:none;
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
 (0,8)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.35pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>20 до &lt; 30<sup>б</sup><o=
:p></o:p></span></p>
  </td>
  <td width=3D138 valign=3Dbottom style=3D'width:103.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>90=
0<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>35=
 (0,6)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>21=
00<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>75=
 (1,3)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.35pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30 до &lt; 40<sup>б</sup></=
span><!--[if supportFields]><sup><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:=
field-begin'></span>
  NOTEREF _Ref167153755 \h<span style=3D'mso-spacerun:yes'>  </span>\*
  MERGEFORMAT </span></sup><![endif]--><sup><span lang=3DUK style=3D'mso-bi=
di-font-size:
  12.0pt'><!--[if gte mso 9]><xml>
   <w:data>08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F0052=
00650066003100360037003100350033003700350035000000</w:data>
  </xml><![endif]--></span></sup><!--[if supportFields]><sup><span lang=3DUK
  style=3D'mso-bidi-font-size:12.0pt'><span style=3D'mso-element:field-end'=
></span></span></sup><![endif]--><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>
  </td>
  <td width=3D138 valign=3Dbottom style=3D'width:103.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12=
00<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>31=
 (0,5)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>27=
00<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>65=
 (1,1)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.35pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40 до &lt; 60<o:p></o:p></s=
pan></p>
  </td>
  <td width=3D138 valign=3Dbottom style=3D'width:103.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>24=
00<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>45=
 (0,8)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
00<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>55=
 (0,9)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.35pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>60 до &lt; 100<o:p></o:p></=
span></p>
  </td>
  <td width=3D138 valign=3Dbottom style=3D'width:103.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>27=
00<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>35=
 (0,6)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>33=
00<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>40=
 (0,7)<o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D110 valign=3Dbottom style=3D'width:82.3pt;border:solid window=
text 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm .5pt 0cm .5pt;height:
  11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span class=3DSimSun><span lang=3DUK style=3D'mso-bidi=
-font-size:
  12.0pt;font-family:"Times New Roman",serif'>&#8805; </span></span><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>100<o:p></o:p></span></p>
  </td>
  <td width=3D138 valign=3Dbottom style=3D'width:103.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
00<o:p></o:p></span></p>
  </td>
  <td width=3D113 valign=3Dbottom style=3D'width:3.0cm;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>25=
 (0,4)<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dbottom style=3D'width:106.3pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>36=
00<o:p></o:p></span></p>
  </td>
  <td width=3D123 valign=3Dbottom style=3D'width:92.15pt;border-top:none;bo=
rder-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm .5pt 0=
cm .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin:0cm;margin-bottom:.00=
01pt;
  text-align:center'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30=
 (0,5)<o:p></o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>а </span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>Маса тіла на момент лікування.<o:p></o:=
p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><sup><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>б </span></sup><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'>Тільки при ПНГ та аГУС.<o:p></o:p></spa=
n></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'font-size:11.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 24 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Тривалість введення додаткови=
х доз лікарського
засобу Ультоміріс<o:p></o:p></span></p>

<table class=3DMsoNormalTable border=3D0 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D605
 style=3D'width:454.1pt;margin-left:5.65pt;border-collapse:collapse;mso-tab=
le-overlap:
 never;mso-padding-alt:0cm .5pt 0cm .5pt'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:23.55pt'>
  <td width=3D177 valign=3Dtop style=3D'width:132.5pt;border-top:solid wind=
owtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:23.55pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:.6pt;margin-bottom:.0001pt;text-align:cente=
r'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Діапазон маси тіла (кг)<sup=
>а</sup><o:p></o:p></span></p>
  </td>
  <td width=3D188 valign=3Dtop style=3D'width:141.35pt;border-top:solid win=
dowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:23.55pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Додаткова доза<sup>б</sup> =
(мг)<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dtop style=3D'width:180.25pt;border:solid windowt=
ext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:23.55pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
5.9pt;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Мінімальна тривалість інфуз=
ійного
  введення, хвилини (години)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:11.9pt'>
  <td width=3D177 rowspan=3D3 valign=3Dtop style=3D'width:132.5pt;border-to=
p:solid windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:7.7pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#8805; 40 до &lt; 60<o:p><=
/o:p></span></p>
  </td>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15 (0,25)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:11.9pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1200<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>25 (0,42)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:11.9pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>30 (0,5)<o:p></o:p></span><=
/p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:11.9pt'>
  <td width=3D177 rowspan=3D3 valign=3Dtop style=3D'width:132.5pt;border-to=
p:solid windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:7.7pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#8805; 60 до &lt; 100<o:p>=
</o:p></span></p>
  </td>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>12 (0,20)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:11.9pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>22 (0,36)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:11.9pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1800<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.9pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>25 (0,42)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:11.35pt'>
  <td width=3D177 rowspan=3D3 valign=3Dtop style=3D'width:132.5pt;border:so=
lid windowtext 1.0pt;
  border-right:none;mso-border-top-alt:solid windowtext .5pt;mso-border-lef=
t-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:7.7pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>&#8805; 100<o:p></o:p></spa=
n></p>
  </td>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>600<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>10 (0,17)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;height:11.35pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border-top:solid =
windowtext 1.0pt;
  border-left:solid windowtext 1.0pt;border-bottom:none;border-right:none;
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid window=
text .5pt;
  background:white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1500<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  border-bottom:none;mso-border-top-alt:solid windowtext .5pt;mso-border-le=
ft-alt:
  solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt;backgrou=
nd:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>15 (0,25)<o:p></o:p></span>=
</p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:9;mso-yfti-lastrow:yes;height:11.35pt'>
  <td width=3D188 valign=3Dbottom style=3D'width:141.35pt;border:solid wind=
owtext 1.0pt;
  border-right:none;mso-border-top-alt:solid windowtext .5pt;mso-border-lef=
t-alt:
  solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;backgro=
und:
  white;padding:0cm .5pt 0cm .5pt;height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:2.75pt;margin-bottom:.0001pt;text-align:cen=
ter'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>1800<o:p></o:p></span></p>
  </td>
  <td width=3D240 valign=3Dbottom style=3D'width:180.25pt;border:solid wind=
owtext 1.0pt;
  mso-border-alt:solid windowtext .5pt;background:white;padding:0cm .5pt 0c=
m .5pt;
  height:11.35pt'>
  <p class=3DMsoNormal align=3Dcenter style=3D'margin-top:0cm;margin-right:=
0cm;
  margin-bottom:0cm;margin-left:3.0pt;margin-bottom:.0001pt;text-align:cent=
er'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>17 (0,28)<o:p></o:p></span>=
</p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167154359"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>а</span></sup></a><span
style=3D'mso-bookmark:_Ref167154359'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> Маса тіла на момент лікування.</span></span><span lang=3DUK
style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167154364"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>б </span></sup></a><span
style=3D'mso-bookmark:_Ref167154364'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>Для вибору додаткової дози равулізумабу див. таблицю </span></span>=
<span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>22.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Hlk207799198"><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>=
Інструкції
щодо розведення лікарського засобу перед застосуванням див. в розділі «Особ=
ливі
заходи безпеки».<o:p></o:p></span></a></p>

<span style=3D'mso-bookmark:_Hlk207799198'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i><span lang=3DUK style=3D'mso-bidi-=
font-size:
12.0pt'>Діти<o:p></o:p></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність і безпеку застос=
ування равулізумабу
дітям з масою тіла &lt;&nbsp;10 кг з ПНГ та аГУС не встановлено. Доступних =
на
сьогодні даних, описаних у розділі «Побічні реакції», недостатньо, щоб вста=
новити
рекомендації щодо дозування дітям.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Ефективність і безпеку застос=
ування
равулізумабу дітям з гМГ чи ОНМРС не встановлено. Дані відсутні.<o:p></o:p>=
</span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Передозування<span style=3D'm=
so-bidi-font-weight:
bold;mso-bidi-font-style:italic'><o:p></o:p></span></span></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пацієнтам, у яких спостерігає=
ться
передозування, слід негайно припинити інфузію. Необхідно проводити ретельний
нагляд за станом таких пацієнтів для виявлення будь-яких ознак або симптомів
побічних реакцій, а також розпочати відповідне симптоматичне лікування.<o:p=
></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Побічні реакції<o:p></o:p></s=
pan></i></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><i style=3D'mso-bidi-font-style:norma=
l'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Резюме профілю безпеки<o:p></=
o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Найчастішими побічними реакці=
ями при
застосуванні равулізумабу є головний біль (30,6&nbsp;%), інфекції верхніх
дихальних шляхів (21,6&nbsp;%), назофарингіт (20,4&nbsp;%), діарея (18,7&nb=
sp;%),
лихоманка (17,7&nbsp;%), нудота (15&nbsp;%), артралгія (14,4&nbsp;%), біль у
спині (13,6&nbsp;%), втомлюваність (13,3&nbsp;%), біль у животі (12,3&nbsp;=
%),
запаморочення (10,7&nbsp;%) та інфекції сечовивідних шляхів (10,7&nbsp;%).
Найбільш серйозними побічними реакціями є менінгококова інфекція (0,7&nbsp;=
%),
включаючи менінгококовий сепсис, менінгококовий менінгіт, менінгококовий
енцефаліт, менінгококову інфекцію (див. розділ «Особливості застосування») =
та
дисеміновану гонококову інфекцію (0,2&nbsp;%), включаючи дисеміновану
гонококову інфекцію та гонококову інфекцію.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Перелік побічних реакцій,
представлений у формі таблиці <o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У таблиці 25 наведено побічні
реакції, які спостерігалися в клінічних дослідженнях і в післяреєстраційний
період.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Побічні реакції перелічено за=
 класами
систем органів відповідно до словника MedDRA та за частотою виникнення з
використанням таких критеріїв її оцінки: дуже часто (&#8805; 1/10), часто
(&#8805; 1/100 до &lt;&nbsp;1/10), нечасто (&#8805; 1/1000 до &lt; 1/100),
рідко (&#8805; 1/10000 до &lt; 1/1000), дуже рідко (&lt; 1/10000) та частота
невідома (на підставі наявних даних оцінити не можна). У межах кожної групи=
 за частотою
побічні реакції представлено у порядку зменшення серйозності.</span><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p></o:p></span>=
</p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bidi-font-size:12.0pt;mso-ansi-language:RU'><o:p>&nbsp;</o:p><=
/span></p>

<p class=3DMsoNormal align=3Dright style=3D'margin:0cm;margin-bottom:.0001p=
t;
text-align:right'><span lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Табли=
ця 25 <span
style=3D'mso-tab-count:1'>   </span><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Побічні реакції на застосуван=
ня лікарського
засобу у клінічних дослідженнях та протягом післяреєстраційного періоду <o:=
p></o:p></span></p>

<table class=3DMsoNormalTable border=3D1 cellspacing=3D0 cellpadding=3D0 wi=
dth=3D642
 style=3D'width:481.8pt;border-collapse:collapse;border:none;mso-border-alt=
:solid windowtext .25pt;
 mso-table-overlap:never;mso-padding-alt:0cm 6.5pt 0cm 6.5pt;mso-border-ins=
ideh:
 .25pt solid windowtext;mso-border-insidev:.25pt solid windowtext'>
 <tr style=3D'mso-yfti-irow:0;mso-yfti-firstrow:yes;height:34.0pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 4.25pt=
 0cm 4.25pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Клас систем органів за MedD=
RA<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Дуже часто<b><o:p></o:p></b=
></span></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(&#8805; 1/10)<b><o:p></o:p=
></b></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border:solid windowte=
xt 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Часто<b><o:p></o:p></b></sp=
an></p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(&#8805; 1/100 до &lt; 1/10=
)<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border:solid windowt=
ext 1.0pt;
  border-left:none;mso-border-left-alt:solid windowtext .25pt;mso-border-al=
t:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Нечасто <o:p></o:p></span><=
/p>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>(&#8805; 1/1000 до &lt;&nbs=
p;1/100)<b><o:p></o:p></b></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:1;height:39.7pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інфекційні та паразитарні з=
ахворювання<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інфекції сечовивідних шляхі=
в<sup>а</sup>,
  інфекція верхніх дихальних шляхів, назофарингіт<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Менінгококова інфекція<sup>=
б</sup>,
  дисемінована гонококова інфекція<sup>в</sup><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:2;height:39.7pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення з боку імунної си=
стеми<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Гіперчутливість<sup>ґ</sup>=
<o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:39.7pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Анафілактична реакція<sup>г=
</sup><o:p></o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:3;height:34.0pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення з боку нервової с=
истеми<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Головний біль, запамороченн=
я<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:4;height:33.15pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:33.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення з боку шлунково-к=
ишкового
  тракту<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:33.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Діарея, нудота, біль у живо=
ті<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:33.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Блювання, <br>
  диспепсія<o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:33.15pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:5;height:34.0pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення з боку шкіри та
  підшкірної клітковини<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Кропив’янка, <br>
  свербіж, висип <o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:6;height:34.0pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Порушення з боку скелетно-м=
’язової
  та сполучної тканини<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Артралгія, <br>
  біль у спині<o:p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Міалгія, <br>
  м’язові спазми<o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:7;height:35.45pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:35.45pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Загальні розлади та реакції=
 в місці
  введення<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:35.45pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лихоманка, втомлюваність<o:=
p></o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:35.45pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Грипоподібне захворювання, =
<br>
  озноб, астенія<o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:35.45pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
 <tr style=3D'mso-yfti-irow:8;mso-yfti-lastrow:yes;height:34.0pt'>
  <td width=3D156 valign=3Dtop style=3D'width:117.1pt;border:solid windowte=
xt 1.0pt;
  border-top:none;mso-border-top-alt:solid windowtext .25pt;mso-border-alt:
  solid windowtext .25pt;background:white;padding:0cm 6.5pt 0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Травми, отруєння та ускладн=
ення
  процедур<b><o:p></o:p></b></span></p>
  </td>
  <td width=3D174 valign=3Dtop style=3D'width:130.85pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
  <td width=3D142 valign=3Dtop style=3D'width:106.3pt;border-top:none;borde=
r-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Реакція, пов’язана з інфузі=
єю<o:p></o:p></span></p>
  </td>
  <td width=3D170 valign=3Dtop style=3D'width:127.55pt;border-top:none;bord=
er-left:
  none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1=
.0pt;
  mso-border-top-alt:solid windowtext .25pt;mso-border-left-alt:solid windo=
wtext .25pt;
  mso-border-alt:solid windowtext .25pt;background:white;padding:0cm 6.5pt =
0cm 6.5pt;
  height:34.0pt'>
  <p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align=
:justify'><span
  lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>
  </td>
 </tr>
</table>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167157512"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>а</span></sup></a><span
style=3D'mso-bookmark:_Ref167157512'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> Інфекція сечовивідних шляхів — це загальний термін, який охоплює т=
акі
терміни: інфекція сечовивідних шляхів, бактеріальна інфекція сечовивідних
шляхів, інфекція сечовивідних шляхів, спричинена ентерококами, й інфекція
сечовивідних шляхів, спричинена <i style=3D'mso-bidi-font-style:normal'>Esc=
herichia
coli.<o:p></o:p></i></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:_Ref167157512'><sup><span lang=3DUK style=3D'mso-bidi=
-font-size:
12.0pt'>б</span></sup></span><span style=3D'mso-bookmark:_Ref167157512'><sp=
an
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'> Менінгококова інфекція охопл=
ює такі
терміни: менінгококова інфекція, менінгококовий сепсис, менінгококовий мені=
нгіт
та менінгококовий енцефаліт</span></span><span lang=3DUK style=3D'mso-bidi-=
font-size:
12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167157517"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>в</span></sup></a><span
style=3D'mso-bookmark:_Ref167157517'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> Дисемінована гонококова інфекція включає в себе такі терміни, як д=
исемінована
гонококова інфекці</span></span><span lang=3DUK style=3D'mso-bidi-font-size=
:12.0pt'>я
та гонококова інфекція.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167157522"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>г</span></sup></a><span
style=3D'mso-bookmark:_Ref167157522'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> Оцінено на основі післяреєстраційного досвіду застосування</span><=
/span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3D"_Ref167157530"><sup><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>ґ</span></sup></a><span
style=3D'mso-bookmark:_Ref167157530'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'> Гіперчутливість — це загальний термін для позначення гіперчутливос=
ті
до лікарського засобу з відповідною причинно-наслідковою залежністю та
гіперчутливост</span></span><span lang=3DUK style=3D'mso-bidi-font-size:12.=
0pt'>і.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Опис окремих побічних реакцій=
<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Менінгококова інфекція / сепс=
ис / енцефаліт
<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Вакцинація знижує, але не усу=
ває
ризик розвитку менінгококової інфекції. У клінічних дослідженнях у
&lt;&nbsp;1&nbsp;% пацієнтів розвинулися серйозні менінгококові інфекції під
час лікування равулізумабом; усі вони були дорослими пацієнтами з ПНГ або О=
НМРС,
які були вакциновані.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Див. розділ «Особливості
застосування» для отримання інформації про профілактику та лікування
підозрюваної менінгококової інфекції. У пацієнтів, які отримували равулізум=
аб,
менінгококові інфекції проявлялися у вигляді менінгококового сепсису та
менінгококового енцефаліту. Пацієнтів слід проінформувати щодо ознак і
симптомів менінгококової інфекції та рекомендувати негайно звернутися по
медичну допомогу.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Інфузійні реакції<o:p></o:p><=
/span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У клінічних дослідженнях інфу=
зійні
реакції були частими (&#8805;&nbsp;1&nbsp;%). Ці явища, які мали від легког=
о до
середнього ступінь тяжкості та були минущими, включали біль у нижній частині
спини, біль у животі, м’язові спазми, різке зниження артеріального тиску,
підвищення артеріального тиску, озноб, дискомфорт у кінцівках, гіперчутливі=
сть
(алергічна реакція), дисгевзію (неприємний присмак у роті) та сонливість. З=
азначені
реакції не потребували припинення застосування равулізумабу.<o:p></o:p></sp=
an></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Імуногенність</span></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У дослідженнях за участю доро=
слих
пацієнтів з ПНГ (N =3D 475), дітей з ПНГ (N =3D 13), пацієнтів з аГУС (N =
=3D 89), з
гМГ (N =3D 86) та з ОНМРС (N =3D 58) повідомлялося тільки про 2 (0,3&nbsp;%)
випадки появи антитіл до лікарського засобу на тлі терапії равулізумабом (у=
 1
дорослого пацієнта з ПНГ та 1 дорослого пацієнта з аГУС). Поява антитіл до
лікарського засобу мала тимчасовий характер, їхній титр був низьким, і
кореляції з клінічною відповіддю або побічними явищами не відзначено.<o:p><=
/o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p><span style=3D'text-deco=
ration:
 none'>&nbsp;</span></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Педіатрична популяція <o:p></=
o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Пароксизмальна нічна гемоглоб=
інурія
(ПНГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У дітей з ПНГ (N=3D13, віком =
від 9 до
17 років), включених у дослідження за участю пацієнтів дитячого віку з ПНГ
(дослідження ALXN1210-PNH-304), профіль безпеки був подібним до того, що
спостерігався у дорослих пацієнтів з ПНГ. Найчастішими побічними реакціями,=
 про
які повідомлялося в пацієнтів дитячого віку з ПНГ, були біль у животі, нудо=
та,
назофарингіт і головний біль, які спостерігалися у 3 пацієнтів (23,1 %).<o:=
p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Атиповий гемолітико-уремічний=
 синдром
(аГУС)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>У пацієнтів дитячого віку зі
встановленим діагнозом аГУС (N=3D34, віком від 10 місяців до 18 років), вкл=
ючених
у дослідження ALXN1210-aHUS-312, профіль безпеки равулізумабу був подібним =
до
того, що спостерігався у дорослих пацієнтів зі встановленим діагнозом аГУС.
Профілі безпеки в різних вікових підгрупах пацієнтів дитячого віку виявилися
подібними. Дані з безпеки застосування пацієнтам віком до 2 років обмежені 4
пацієнтами. Найчастішими побічними реакціями (&gt; 20&nbsp;%), про які
повідомлялося в пацієнтів дитячого віку, були лихоманка, блювання, діарея,
головний біль, назофарингіт, інфекція верхніх дихальних шляхів та біль у
животі. <o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Генералізована міастенія грав=
іс (гМГ)<o:p></o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу пац=
ієнтам
дитячого віку з гМГ не вивчалося.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'><o:p>&nbsp;</o:p></span></i></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i
style=3D'mso-bidi-font-style:normal'><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt'>Оптиконевромієліт з розладом спектру (ОНМРС)<o:p></o:p></span></i><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Застосування равулізумабу пац=
ієнтам
дитячого віку з ОНМРС не вивчалося.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><u><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Повідомлення про підозрювані =
побічні
реакції<o:p></o:p></span></u></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-font-family:Calibr=
i;
mso-bidi-language:AR-SA;layout-grid-mode:both'>Повідомлення про побічні реа=
кції
після реєстрації лікарського засобу має важливе значення. Це дає змогу
проводити моніторинг співвідношення користь/ризик при застосуванні цього
лікарського засобу. Медичним та фармацевтичним працівникам, а також пацієнт=
ам
або їхнім законним представникам слід повідомляти про усі випадки підозрюва=
них
побічних реакцій та відсутності ефективності лікарського засобу через
Автоматизовану інформаційну систему з фармаконагляду за посиланням: </span>=
<span
lang=3DUK><a href=3D"https://aisf.dec.gov.ua"><span style=3D'mso-bidi-font-=
size:12.0pt;
mso-fareast-font-family:Calibri;color:windowtext;mso-bidi-language:AR-SA;
layout-grid-mode:both;text-decoration:none;text-underline:none'>https://ais=
f.dec.gov.ua</span></a></span><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-font-family:Calibr=
i;
mso-bidi-language:AR-SA;layout-grid-mode:both'>.<u><o:p></o:p></u></span></=
p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Термін придатності</span></b><span lang=3DUK style=3D'mso-bidi-font=
-size:
12.0pt;mso-bidi-font-weight:bold;mso-bidi-font-style:italic'><o:p></o:p></s=
pan></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>18&nbsp;місяців.<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-font-family:Calibr=
i;
mso-bidi-language:AR-SA'>Після розведення лікарський засіб слід вводити
негайно. Однак хімічна та фізична стабільність лікарського засобу після
розведення підтверджена при температурі 2–8 °C протягом періоду до 24 годин,
при кімнатній температурі – протягом періоду до 4 годин.</span><a
name=3Dbookmark44></a><a name=3Dbookmark43><span style=3D'mso-bookmark:book=
mark44'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p></o:p></span></b></span></a></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:bookmark43'><span style=3D'mso-bookmark:bookmark44'><=
span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></spa=
n></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
style=3D'mso-bookmark:bookmark43'><span style=3D'mso-bookmark:bookmark44'><=
b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Умови зберігання</span></b></=
span></span><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зберігати в холодильнику (2–8=
&nbsp;°C).<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Не заморожувати.<o:p></o:p></=
span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Зберігати флакон в оригінальн=
ій
упаковці для захисту від дії світла. Зберігати в недоступному для дітей міс=
ці.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Умови зберігання після розвед=
ення
лікарського засобу див.&nbsp;у розділі&nbsp;«Термін придатності».<o:p></o:p=
></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><a
name=3Dbookmark40></a><a name=3Dbookmark39><span style=3D'mso-bookmark:book=
mark40'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Несумісність</span></b></span=
></a><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p></o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Лікарський засіб не можна змі=
шувати з
іншими лікарськими засобами, за винятком зазначених у розділі&nbsp; «Особли=
ві
заходи безпеки».<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Для розведення слід використо=
вувати
тільки розчин натрію хлориду 9&nbsp;мг/мл (0,9&nbsp;%) для ін’єкцій.<o:p></=
o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Упаковка<o:p></o:p></span></b=
></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-bidi-font-weight:bold'>Cте=
рильний
концентрат для розчину для інфузій (300 мг/3 мл) у скляному флаконі з пробк=
ою
та обтискним ковпачком з накладкою «flip-off»; по 1 флакону в картонній кор=
обці
або стерильний концентрат для розчину для інфузій (1100 мг/11 мл) у скляному
флаконі з пробкою та обтискним ковпачком з накладкою «flip-off»; по 1 флако=
ну в
картонній коробці.<o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'><o:p>&nbsp;</o:p></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Категорія відпуску<span style=3D'mso-bidi-font-weight:bold'><o:p></=
o:p></span></span></b></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>За рецептом.<span style=3D'ms=
o-bidi-font-weight:
bold'><o:p></o:p></span></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b
style=3D'mso-bidi-font-weight:normal'><span lang=3DUK style=3D'mso-bidi-fon=
t-size:
12.0pt'>Виробник</span></b><span lang=3DUK style=3D'mso-bidi-font-size:12.0=
pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:RU;mso-bi=
di-language:
AR-SA;layout-grid-mode:both'>Алексіон Фарма Інтернешнл Оперейшнз Лімітед / =
<a
name=3D"_Hlk208238832">Alexion Pharma International Operations Limited<o:p>=
</o:p></a></span></p>

<span style=3D'mso-bookmark:_Hlk208238832'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'>Місцезнаходження виробника та=
 адреса
місця провадження його діяльності </span></b><span lang=3DUK style=3D'mso-b=
idi-font-size:
12.0pt'><o:p></o:p></span></p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:RU;mso-bi=
di-language:
AR-SA;layout-grid-mode:both'>Виробничі потужності Алексіон в Дубліні (ADMF)=
: </span></i><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt;mso-fareast-language:RU;mso-bi=
di-language:
AR-SA;layout-grid-mode:both'>Коледж Бізнес енд Технолоджі Парк, Бланчардста=
ун
Роуд Норт, Дублін 15, D15&nbsp;R925, Ірландія&nbsp;/&nbsp;<a
name=3D"_Hlk208238841"><i>Alexion Dublin Manufacturing Facility (ADMF): </i=
>College
Business and Technology Park, Blanchardstown Road North, Dublin 15,
D15&nbsp;R925, Ireland <i><o:p></o:p></i></a></span></p>

<span style=3D'mso-bookmark:_Hlk208238841'></span>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><b><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></b><=
/p>

<p class=3DMsoNormal style=3D'margin:0cm;margin-bottom:.0001pt;text-align:j=
ustify'><span
lang=3DUK style=3D'mso-bidi-font-size:12.0pt'><o:p>&nbsp;</o:p></span></p>

</div>

</body>

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